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Generation of Functional Thymocytes in the Human Adult
Open accessAbstract
Reconstituting the immune response will be critical for the survival of HIV-infected individuals once viral load is brought under control. While the adult thymus was previously thought to be relatively inactive, new data suggest it may play a role in T cell reconstitution. We examined thymopoiesis in adults up to 56 years of age and found active T cell receptor (TCR) rearrangement, generating a diverse TCR Vbeta repertoire. The resulting thymocytes are functional and are capable of responding to costimulatory signals. These data demonstrate that the adult thymus remains active late in life and contributes functional T cells to the peripheral lymphoid pool.
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Some functional thymic tissue remains even in elderly humans.
“Indeed, some functional thymic tissue remains even in elderly humans (44).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [44]
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References 24 · Cited by 367
Metadata
- Authors
- Jamieson, B. D., Douek, D. C., Killian, S., Hultin, L. E., Scripture-Adams, D. D., Giorgi, J. V., Marelli, D., Koup, R. A., & Zack, J. A.
- Affiliations
- University of California, Los Angeles (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Jamieson, Beth D
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1999-05
- Volume
- 10
- Issue
- 5
- Pages
- 569-575
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2078659852
- Cited by
- 367
- References
- 24
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 9 · 2016: 14 · 2015: 13 · 2014: 11 · 2013: 13 · 2012: 7
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21ag016825-02)
- National Institute on Aging (AG16825)
- National Institute of Allergy and Infectious Diseases (R01AI036554, AI36554, AI-36059)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- adult thymus, thymopoiesis, thymocytes, T-cell receptor gene rearrangement, TCR Vβ repertoire, T cell reconstitution, HIV infection, costimulatory signals, T cell development
- MeSH terms
- Adult, Cell Division, Cells, Cultured, Humans, Lymphocyte Activation, Middle Aged, Receptors, Antigen, T-Cell, T-Lymphocytes, Thymus Gland, Genetic Variation, Gene Rearrangement, T-Lymphocyte, CD4-Positive T-Lymphocytes, HIV Infections, T-Lymphocyte Subsets
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