Douek, Daniel C.

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine

HIV Research and TreatmentHIV-related health complications and treatments

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A human memory T cell subset with stem cell–like properties

Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

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Changes in thymic function with age and during the treatment of HIV infection

Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature

HIV Research and TreatmentT-cell and B-cell Immunology

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Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature

Immunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology

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. Plasma levels of soluble CD14 independently predict mortality in HIV infection.

Sandler, N. G., Wand, H., Roque, A., Law, M., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., et al. (2011) · The Journal of Infectious Diseases

HIV Research and TreatmentHIV-related health complications and treatments

Cited by 1,106

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

Brenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood

HIV Research and TreatmentT-cell and B-cell Immunology

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Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

Wilkinson, T. M., Li, C. K. F., Chui, C. S. C., Huang, A. K. Y., Perkins, M., Liebner, J. C., Lambkin-Williams, R., Gilbert, A., Oxford, J., Nicholas, B., et al. (2012) · Nature Medicine

Influenza Virus Research StudiesRespiratory viral infections research

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PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

Petrovas, C., Casazza, J. P., Brenchley, J. M., Price, D. A., Gostick, E., Adams, W. C., Precopio, M. L., Schacker, T., Roederer, M., Douek, D. C., et al. (2006) · The Journal of Experimental Medicine

T-cell and B-cell ImmunologyHIV Research and Treatment

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Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

Pegu, A., O’Connell, S. E., Schmidt, S. D., O’Dell, S., Talana, C. A., Lai, L., Albert, J., Anderson, E., Bennett, H., Corbett, K. S., et al. (2021) · Science

SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

Cited by 527

Microbial Translocation Across the GI Tract

Brenchley, J. M., & Douek, D. C. (2012) · Annual Review of Immunology

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 496

Cold Urticaria, Immunodeficiency, and Autoimmunity Related to PLCG2 Deletions

Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., Subramanian, N., Bunney, T. D., Baxendale, R. W., Martins, M. S., et al. (2012) · New England Journal of Medicine

Immunodeficiency and Autoimmune DisordersInflammasome and immune disorders

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CD8+ T cell efficacy in vaccination and disease

Appay, V., Douek, D. C., & Price, D. A. (2008) · Nature Medicine

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 393

Identification of genetically intact HIV-1 proviruses in specific CD4 + T cells from effectively treated participants

Hiener, B., Horsburgh, B. A., Eden, J.-S., Barton, K., Schlub, T. E., Lee, E., von Stockenstrom, S., Odevall, L., Milush, J. M., Liegler, T., et al. (2017) · Cell Reports

HIV Research and TreatmentVirus-based gene therapy research

Cited by 370

Generation of Functional Thymocytes in the Human Adult

Jamieson, B. D., Douek, D. C., Killian, S., Hultin, L. E., Scripture-Adams, D. D., Giorgi, J. V., Marelli, D., Koup, R. A., & Zack, J. A. (1999) · Immunity

T-cell and B-cell ImmunologyHIV Research and Treatment

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Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

Joyce, M. G., Wheatley, A. K., Thomas, P. V., Chuang, G.-Y., Soto, C., Bailer, R. T., Druz, A., Georgiev, I. S., Gillespie, R. A., Kanekiyo, M., et al. (2016) · Cell

Influenza Virus Research Studiesvaccines and immunoinformatics approaches

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Infection and Vaccine-Induced Neutralizing-Antibody Responses to the SARS-CoV-2 B.1.617 Variants

Edara, V.-V., Pinsky, B. A., Suthar, M. S., Lai, L., Davis-Gardner, M. E., Floyd, K., Flowers, M. W., Wrammert, J., Hussaini, L., Ciric, C. R., et al. (2021) · New England Journal of Medicine

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

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Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection

Sandler, N. G., Koh, C., Roque, A., Eccleston, J. L., Siegel, R. B., Demino, M., Kleiner, D. E., Deeks, S. G., Liang, T. J., Heller, T., et al. (2011) · Gastroenterology

Liver Disease and TransplantationHepatitis C virus research

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Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

Corbett, K. S., Nason, M. C., Flach, B., Gagne, M., O’Connell, S., Johnston, T. S., Shah, S. N., Edara, V. V., Floyd, K., Lai, L., et al. (2021) · Science

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Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

Saunders, K. O., Lee, E., Parks, R., Martinez, D. R., Li, D., Chen, H., Edwards, R. J., Gobeil, S., Barr, M., Mansouri, K., et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

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What policy makers need to know about COVID-19 protective immunity

Altmann, D. M., Douek, D. C., & Boyton, R. J. (2020) · The Lancet

SARS-CoV-2 and COVID-19 ResearchCOVID-19 epidemiological studies

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Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial

Casazza, J. P., Cale, E. M., Narpala, S., Yamshchikov, G. V., Coates, E. E., Hendel, C. S., Novik, L., Holman, L. A., Widge, A. T., Apte, P., et al. (2022) · Nature Medicine

Virus-based gene therapy researchHIV Research and Treatment

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Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

Corbett, K. S., Nason, M. C., Flach, B., Gagne, M., O’ Connell, S., Johnston, T. S., Shah, S. N., Edara, V. V., Floyd, K., Lai, L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

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Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1

Shangguan, S., Ehrenberg, P. K., Geretz, A., Yum, L., Kundu, G., May, K., Fourati, S., Nganou-Makamdop, K., Williams, L. D., Sawant, S., et al. (2021) · eLife

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