The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling
Open accessAbstract
It is not known how immunogenic versus tolerogenic cellular responses are signaled by receptors such as the B cell antigen receptor (BCR). Here we compare BCR signaling in naive cells that respond positively to foreign antigen and self-tolerant cells that respond negatively to self-antigen. In naive cells, foreign antigen triggered a large biphasic calcium response and activated nuclear signals through NF-AT, NF-kappa B, JNK, and ERK/pp90rsk. In tolerant B cells, self-antigen stimulated low calcium oscillations and activated NF-AT and ERK/pp90rsk but not NF-kappa B or JNK. Self-reactive B cells lacking the phosphatase CD45 did not exhibit calcium oscillations or ERK/pp90rsk activation, nor did they repond negatively to self-antigen. These data reveal striking biochemical differences in BCR signaling to the nucleus during positive selection by foreign antigens and negative selection by self-antigens.
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Cites
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Cited by
THE HIGH-AFFINITY I g E RECEPTOR (FcεRI): From Physiology to Pathology
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Calcium signaling mechanisms in T lymphocytes.
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Complement receptor 2/CD21− human naive B cells contain mostly autoreactive unresponsive clones
Isnardi, I., Ng, Y.-S., Menard, L., Meyers, G., Saadoun, D., Srdanovic, I., Samuels, J., Berman, J., Buckner, J. H., Cunningham-Rundles, C., et al. (2010) · Blood · doi:10.1182/blood-2009-09-243071 · Cited by 477
Metadata
- Authors
- Healy, J. I., Dolmetsch, R. E., Timmerman, L. A., Cyster, J. G., Thomas, M. L., Crabtree, G. R., Lewis, R. S., & Goodnow, C. C.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1997-04
- Volume
- 6
- Issue
- 4
- Pages
- 419-428
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2009936338
- Cited by
- 377
- References
- 67
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Healy, J. I., Dolmetsch, R. E., Timmerman, L. A., Cyster, J. G., Thomas, M. L., Crabtree, G. R., Lewis, R. S., & Goodnow, C. C. (1997). Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling. Immunity. https://doi.org/10.1016/s1074-7613(00)80285-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
