A cell culture model for T lymphocyte clonal anergy

Schwartz, Ronald H.

doi:10.1126/science.2113314

Cited by 1,857T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Response and Inflammation

A cell culture model for T lymphocyte clonal anergy

Schwartz, Ronald H.·1990·Science

DOI 10.1126/science.2113314

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Abstract

T lymphocytes respond to foreign antigens both by producing protein effector molecules known as lymphokines and by multiplying. Complete activation requires two signaling events, one through the antigen-specific receptor and one through the receptor for a costimulatory molecule. In the absence of the latter signal, the T cell makes only a partial response and, more importantly, enters an unresponsive state known as clonal anergy in which the T cell is incapable of producing its own growth hormone, interleukin-2, on restimulation. Our current understanding at the molecular level of this modulatory process and its relevance to T cell tolerance are reviewed.

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T cells that receive antigen with suboptimal CD28 co-stimulation and/or high co-inhibition become anergic, with low IL-2 production and G1/S cell cycle arrest.
“It is generally accepted that T cells that are presented antigen along with suboptimal CD28 co-stimulation [4,5] and/or high co-inhibition [17] result in anergic phenotypes, as characterized by their low IL-2 production and cell cycle arrest at the G1/S phase.”
From T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment (2013) · cites this paper as [4]

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Authors: Schwartz, R. H.
Affiliations: National Institutes of Health (US)
Corresponding author: Schwartz, Ronald H.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1990-06-15
Volume: 248
Issue: 4961
Pages: 1349-1356
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.2113314
OpenAlex: W2037626742
Cited by: 1,857
References: 138
Citations by year: 2026: 8 · 2025: 9 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 14 · 2019: 18 · 2018: 14 · 2017: 23 · 2016: 11 · 2015: 17 · 2014: 26 · 2013: 33 · 2012: 19
FWCI: 49.63
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: anergy, T cells, T cell activation, costimulatory signals, interleukin-2, lymphokine production, T cell tolerance, antigen-specific receptors, cell culture model
MeSH terms: Animals, Antigens, Differentiation, T-Lymphocyte, Cells, Cultured, Clone Cells, Gene Expression Regulation, Immune Tolerance, Interleukin-2, Models, Biological, Receptors, Antigen, T-Cell, T-Lymphocytes, Thymus Gland, Second Messenger Systems, Gene Rearrangement, T-Lymphocyte, Signal Transduction, Antigens, CD, CD4 Antigens, CD8 Antigens, Mice

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A cell culture model for T lymphocyte clonal anergy

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