Induction of MHC Class I Expression by the MHC Class II Transactivator CIITA
Open accessAbstract
Major histocompatibility complex (MHC) class I-deficient cell lines were used to demonstrate that the MHC class II transactivator (CIITA) can induce surface expression of MHC class I molecules. CIITA induces the promoter of MHC class I heavy chain genes. The site alpha DNA element is the target for CIITA-induced transactivation of class I. In addition, interferon-gamma (IFNgamma)-induced MHC class I expression also requires an intact site alpha. The G3A cell line, which is defective in CIITA induction, does not induce MHC class I antigen and promoter in response to IFNgamma. Trans-dominant-negative forms of CIITA reduce class I MHC promoter function and surface antigen expression. Collectively, these data argue that CIITA has a role in class I MHC gene induction.
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CIITA (class II trans-activator) is a master regulator of the expression of HLA genes, which encode the MHC class I and II protein complex.
“CIITA (class II trans‐activator) is a master regulator of the expression of HLA genes which encode the MHC class I and II protein complex. 15 , 16”
From The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model (2022) · cites this paper as [16]
The Discussion (p. 6) describes CIITA as a global regulator of the MHC class II antigen-presentation pathway and reports that it can induce MHC class I heavy-chain expression in certain cell lines. But the Discussion (p. 8) says its effect on class I expression may be cell-specific, so calling it a master regulator of both class I and II HLA gene expression overstates the paper's conclusion. (LLM, conf=0.86)
Experimental — accuracy not yet measuredCIITA acts as a master regulator for the expression of MHC class II genes and is also capable of inducing MHC class I genes.
“which acts as a master regulator for the expression of MHC class II genes and is also capable of inducing MHC class I genes. 15 , 16”
From The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model (2022) · cites this paper as [16]
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Cites
Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA
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Research works printed but not linked: 8
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- Authors
- Martin, B. K., Chin, K.-C., Olsen, J. C., Skinner, C. A., Dey, A., Ozato, K., & Ting, J. P.-Y.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institutes of Health (US)
- Corresponding author
- Ting, Jenny P.-Y
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 6
- Issue
- 5
- Pages
- 591-600
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2056145969
- Cited by
- 208
- References
- 1
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 11
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- Centers for Disease Control and Prevention (NCI48185)
- National Cancer Institute (F32 CA67480-02, F32CA067480)
- National Institute of Allergy and Infectious Diseases (AI-29564)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- CIITA, MHC class I expression, interferon-gamma, transcriptional activation
- MeSH terms
- Breast Neoplasms, Carcinoma, Electrophoresis, Polyacrylamide Gel, Genes, MHC Class II, Humans, Mutation, Nuclear Proteins, Promoter Regions, Genetic, Tumor Cells, Cultured, Histocompatibility Antigens Class I, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Chloramphenicol O-Acetyltransferase, Transcriptional Activation, Trans-Activators, Gene Expression Regulation, Neoplastic, Genes, Reporter
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