Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO
Open accessAbstract
The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of MHC II molecules. We report here that Sug1 also has a role in regulating transcription of class I MHC and the MHC II-like molecules, HLA-DM and HLA-DO. Reduction of Sug1 expression causes a decrease in the transcription of MHC I and MHC II-like molecules. In addition, we show that association of Sug1 with MHC promoters is followed by the recruitment of the CREB-binding protein (CBP) and the class II transactivator (CIITA). Reduction of Sug1 expression is accompanied by decreased recruitment of CBP and CIITA to the MHC promoters and decreased histone H3 acetylation in these promoters. These studies suggest that Sug1 plays a critical role in transcription of MHC class I, and the MHC class II-like molecules, HLA-DM and HLA-DO.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Of the 22 genes in the ACE locus, PSMC5 has a top score of 4, while DDX42, MAP3K3, and CD79B each have a score of 3.
“Of the 22 genes in the ACE locus, PSMC5, a key regulator of major histocompatibility complex (MHC)75,76, has a top score of 4, while DDX42, MAP3K3, an important regulator of macrophages and innate immunity77,78, and CD79B, a B lymphocyte antigen receptor subunit, each have a score of 3.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [76]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Proteasome: Paradigm of a Self-Compartmentalizing Protease
Baumeister, W. P., Walz, J., Zühl, F., & Seemüller, E. (1998) · Cell · doi:10.1016/s0092-8674(00)80929-0 · Cited by 1,497 · see citing works
p300/CBP proteins: HATs for transcriptional bridges and scaffolds
Chan, H. M., & La Thangue, N. B. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.13.2363 · Cited by 1,092 · see citing works
The Bare Lymphocyte Syndrome and the Regulation of MHC Expression
Reith, W., & Mach, B. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.331 · Cited by 517 · see citing works
Regulation of MHC class II gene expression by the class II transactivator
Reith, W., LeibundGut‐Landmann, S., & Waldburger, J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1708 · Cited by 463 · see citing works
Masternak, K., Mühlethaler‐Mottet, A., Villard, J., Zufferey, M., Steimle, V., & Reith, W. (2000) · Genes & Development · doi:10.1101/gad.14.9.1156 · Cited by 356 · see citing works
Recruitment of a 19 <i>S</i> Proteasome Subcomplex to an Activated Promoter
Gonzalez, F., Delahodde, A., Kodadek, T., & Johnston, S. A. (2002) · Science · doi:10.1126/science.1069490 · Cited by 338 · see citing works
Ferdous, A., Gonzàlez, F., Sun, L. L., Kodadek, T. J., & Johnston, S. A. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00250-7 · Cited by 268 · see citing works
Class II transactivator regulates the expression of multiple genes involved in antigen presentation.
Chang, C., & Flavell, R. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.765 · Cited by 267 · see citing works
Induction of MHC Class I Expression by the MHC Class II Transactivator CIITA
Martin, B. K., Chin, K.-C., Olsen, J. C., Skinner, C. A., Dey, A., Ozato, K., & Ting, J. P.-Y. (1997) · Immunity · doi:10.1016/s1074-7613(00)80347-7 · Cited by 208 · see citing works
Zhu, X., Linhoff, M. W., Li, G., Chin, K.-C., Maity, S. N., & Ting, J. P.-Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.6051-6061.2000 · Cited by 201 · see citing works
The proteasome and MHC class I antigen processing
Kloetzel, P. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.10.004 · Cited by 197 · see citing works
Epigenetic regulation of MHC-II and CIITA genes
Wright, K. L., & Ting, J. P.-Y. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.07.007 · Cited by 194 · see citing works
CREB Regulates MHC Class II Expression in a CIITA-Dependent Manner
Moreno, C. S., Beresford, G., Louis‐Plence, P., Morris, A. C., & Boss, J. M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80015-1 · Cited by 183 · see citing works
Lee, D., Ezhkova, E., Li, B., Pattenden, S. G., Tansey, W. P., & Workman, J. L. (2005) · Cell · doi:10.1016/j.cell.2005.08.015 · Cited by 178 · see citing works
How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?
Kropshofer, H., Hämmerling, G. J., & Vogt, A. B. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01006-2 · Cited by 128 · see citing works
The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32
Fontes, J. D., Jiang, B., & Peterlin, B. M. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.12.2522 · Cited by 126 · see citing works
Mahanta, S. K., Scholl, T., Yang, F.-C., & Strominger, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6324 · Cited by 115 · see citing works
The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genes
Kern, I., Steimle, V., Siegrist, C., et al. (1995) · International Immunology · doi:10.1093/intimm/7.8.1295 · Cited by 110 · see citing works
Shared regulatory elements in the promoters of MHC class I and class II genes
van den Elsen, P. J., Peijnenburg, A., van Eggermond, M. C. J. A., et al. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01287-0 · Cited by 102 · see citing works
Ferdous, A., Kodadek, T. J., & Johnston, S. A. (2002) · Biochemistry · doi:10.1021/bi020425t · Cited by 93 · see citing works
The ubiquitin–proteasome system regulates p53-mediated transcription at p21waf1 promoter
Zhu, Q., Wani, G., Yao, J., Patnaik, S., Wang, Q.-E., El-Mahdy, M., Praetorius-Ibba, M., & Wani, A. (2007) · Oncogene · doi:10.1038/sj.onc.1210191 · Cited by 77 · see citing works
HLA-DM, HLA-DO and tapasin: functional similarities and differences
Brocke, P., Garbi, N., Momburg, F., et al. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00294-1 · Cited by 76 · see citing works
Zika, E., Fauquier, L., Vandel, L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505045102 · Cited by 68 · see citing works
Drozina, G., Kohoutek, J., Jabrane‐Ferrat, N., et al. (2005) · Springer eBooks · doi:10.1007/3-540-26363-2_7 · Cited by 64 · see citing works
The proteasomal ATPase complex is required for stress-induced transcription in yeast
Sulahian, R., Johnston, S. A., & Kodadek, T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl012 · Cited by 54 · see citing works
Mudhasani, R., & Fontes, J. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5019-5026.2002 · Cited by 53 · see citing works
The 19S proteasome ATPase Sug1 plays a critical role in regulating MHC class II transcription
Bhat, K. P., Turner, J. D., Myers, S. E., Cape, A. D., Ting, J. P.-Y., & Greer, S. F. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2007.12.001 · Cited by 53 · see citing works
Taxman, D. J., Cressman, D. E., & Ting, J. P. ‐. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1410 · Cited by 50 · see citing works
Koues, O. I., Dudley, R. K., Truax, A., Gerhardt, D., Bhat, K., McNeal, S. I., & Greer, S. F. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00535-08 · Cited by 48 · see citing works
Class II transactivator‐induced expression of HLA‐DOβ in HeLa cells
Khalil, H., Deshaies, F., Bellemare‐Pelletier, A., Brunet, A., Faubert, A., Azar, G. A., & Thibodeau, J. (2002) · Tissue Antigens · doi:10.1034/j.1399-0039.2002.600504.x · Cited by 25 · see citing works
The Expression of HLA-DO (H2-O) in B Lymphocytes
Chen, X., & Jensen, P. E. (2004) · Immunologic Research · doi:10.1385/ir:29:1-3:019 · Cited by 23 · see citing works
GTP-dependent Recruitment of CIITA to the Class II Major Histocompatibility Complex Promoter
Bewry, N. N., Bolick, S. C. E., Wright, K. L., & Harton, J. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611747200 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Alzheimer Disease Genetics Consortium (ADGC), Kunkle, B. W., The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, P. A. E. R. F. A. D. C. (., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0358-2 · Cited by 2,946 · see citing works
- Authors
- Inostroza-Nieves, Y., Venkatraman, P., & Zavala-Ruiz, Z.
- Affiliations
- Advanced Centre for Treatment, Research and Education in Cancer (IN)
- Venue
- Immunology Letters
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 147
- Issue
- 1-2
- Pages
- 67-74
- ISSN
- 0165-2478 (ISSN-L)
- PMC
- PMC3654650
- OpenAlex
- W1997183350
- Cited by
- 9
- References
- 32
- Citations by year
- 2023: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2014: 2
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunology Letters (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R25GM061838)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- SUG1, HLA-DM, HLA-DO, CREB-binding protein, CIITA, histone H3 acetylation, transcriptional regulation
- MeSH terms
- ATPases Associated with Diverse Cellular Activities, Acetylation, Cell Line, Gene Expression Regulation, Histones, HLA-D Antigens, Humans, Interferon-gamma, Nuclear Proteins, Promoter Regions, Genetic, Transcription Factors, Transcription, Genetic, Histocompatibility Antigens Class I, Trans-Activators, RNA Interference, Proteasome Endopeptidase Complex, Adaptor Proteins, Signal Transducing, CREB-Binding Protein, LIM Domain Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
