The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases
Open accessAbstract
Activation of ICE/Ced-3 family proteases (caspases) has been proposed to mediate both the granule exocytosis and Fas-Fas ligand pathways of rapid target cell death by cytotoxic T lymphocytes. In agreement with this model, two peptide fluoromethyl ketone caspase inhibitors and baculovirus p35 blocked apoptotic nuclear damage and target cell lysis by the CTL-mediated Fas-Fas ligand pathway. The peptide caspase inhibitors also blocked drug-induced apoptotic cell death in tumor cells. In contrast, the caspase inhibitors blocked CTL granule exocytosis-induced target apoptotic nuclear damage, but did not inhibit target lysis. These results are consistent with recent demonstrations that granzyme B can activate caspases leading to apoptotic nuclear damage, but show that target cell lysis by CTL granule exocytosis occurs by a caspase-independent pathway.
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Cites
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Cited by
Lymphocyte-Mediated Cytotoxicity
Russell, J. H., & Ley, T. J. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100201.131730 · Cited by 1,122
How do cytotoxic lymphocytes kill their targets?
Shresta, S., Pham, C. T., Thomas, D. A., Graubert, T. A., & Ley, T. J. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80227-6 · Cited by 391
Sutton, V. R., Davis, J. E., Cancilla, M., Johnstone, R. W., Ruefli, A. A., Sedelies, K., Browne, K. A., & Trapani, J. A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.10.1403 · Cited by 386
Caspase-independent programmed cell death with necrotic morphology
Kitanaka, C., & Kuchino, Y. (1999) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400526 · Cited by 375
Smyth, M. J., Krasovskis, E., Sutton, V. R., & Johnstone, R. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7024 · Cited by 356
Metadata
- Authors
- Sarin, A., Williams, M. S., Alexander-Miller, M. A., Berzofsky, J. A., Zacharchuk, C. M., & Henkart, P. A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 6
- Issue
- 2
- Pages
- 209-215
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2078147974
- Cited by
- 225
- References
- 1
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases. https://app.cochat.ai/papers/10.1016/s1074-7613(00)80427-6
- The paper
- Sarin, A., Williams, M. S., Alexander-Miller, M. A., Berzofsky, J. A., Zacharchuk, C. M., & Henkart, P. A. (1997). Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases. Immunity. https://doi.org/10.1016/s1074-7613(00)80427-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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