The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
Lymphocyte-Mediated Cytotoxicity
Abstract
Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the Fas pathway. The granule exocytosis pathway utilizes perforin to traffic the granzymes to appropriate locations in target cells, where they cleave critical substrates that initiate DNA fragmentation and apoptosis; granzymes A and B induce death via alternate, nonoverlapping pathways. The Fas/FasL system is responsible for activation-induced cell death but also plays an important role in lymphocyte-mediated killing under certain circumstances. The interplay between these two cytotoxic systems provides opportunities for therapeutic interventions to control autoimmune diseases and graft vs. host disease, but oversuppression of these pathways may also lead to increased viral susceptibility and/or decreased tumor cell killing.
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Cites
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Cited by
Apoptosis: A Review of Programmed Cell Death
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Cancer immunoediting: from immunosurveillance to tumor escape
Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., & Schreiber, R. D. (2002) · Nature Immunology · doi:10.1038/ni1102-991 · Cited by 5,393
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
Zhou, Z., He, H., Wang, K., Shi, X., Wang, Y., Su, Y., Wang, Y., Li, D., Liu, W., Zhang, Y., et al. (2020) · Science · doi:10.1126/science.aaz7548 · Cited by 1,317
Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
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Self-citation
Metadata
- Authors
- Russell, J. H., & Ley, T. J.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2002-04
- Volume
- 20
- Issue
- 1
- Pages
- 323-370
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2122541507
- Cited by
- 1,122
- References
- 221
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- closed
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