The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regulation of IL-4 Expression by Activation of Individual Alleles
Open accessAbstract
To study the in vivo role of IL-4-expressing cells, we developed a strategy to tag these cells, by generating mice in which one IL-4 allele was replaced with a cDNA encoding the human CD2 (huCD2) cell-surface molecule. Expression of the huCD2 reporter was, like IL-4, restricted to the appropriately polarized T helper 2 cells. However, most of the cells expressed only the IL-4 or the targeted allele. Analysis of the frequency of monoallelic versus biallelic expression suggests that the activation of each individual allele is regulated by a stochastic process whose probability can be augmented by increasing the strength of signal delivered through the TCR. Allele-specific activation may be a general feature of cytokine regulation that contributes to the functional diversity within T helper cell subpopulations.
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Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
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Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D., & Paul, W. E. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.3.921 · Cited by 954
Cited by
Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells
Deng, Q., Ramsköld, D., Reinius, B., & Sandberg, R. (2014) · Science · doi:10.1126/science.1245316 · Cited by 1,345
Distinct Effects of T-bet in T H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells
Szabo, S. J., Sullivan, B. M., Stemmann, C., Satoskar, A. R., Sleckman, B. P., & Glimcher, L. H. (2002) · Science · doi:10.1126/science.1065543 · Cited by 1,172
Molecular Mechanisms RegulatinG Th1 Immune Responses
Szabo, S. J., Sullivan, B. M., Peng, S. L., & Glimcher, L. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140942 · Cited by 1,019
Lineage commitment in the immune system: the T helper lymphocyte grows up
Glimcher, L. H., & Murphy, K. M. (2000) · Genes & Development · doi:10.1101/gad.14.14.1693 · Cited by 623
In Vivo CD4 + T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm
Ruterbusch, M., Pruner, K. B., Shehata, L., & Pepper, M. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-103019-085803 · Cited by 550
Metadata
- Authors
- Rivière, I., Sunshine, M. J., & Littman, D. R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 9
- Issue
- 2
- Pages
- 217-228
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2044795335
- Cited by
- 164
- References
- 3
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rivière, I., Sunshine, M. J., & Littman, D. R. (1998). Regulation of IL-4 Expression by Activation of Individual Alleles. Immunity. https://doi.org/10.1016/s1074-7613(00)80604-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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