CoChat
Sign Up
Cited by 134

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

GADD45γ Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector TH1 Cells

Lu, Binfeng, Yu, Hong, Chow, Chi-wing, Li, Baiyong, Zheng, Wei-ping, Davis, Roger J, Flavell, Richard A·2001·Immunity
DOI 10.1016/s1074-7613(01)00141-8
Open this paper in CoChat — free account

Abstract

The p38 and JNK stress-activated MAPK signal transduction pathways are activated by T cell receptor (TCR) signaling and are required for IFN-gamma production by TH1 effector cells. Here, we show that the expression of GADD45gamma is induced during T cell activation and that the level of expression is higher in TH1 cells than in TH2 cells. TH1 cells from GADD45gamma(-/-) mice are severely compromised in their abilities to activate p38 and JNK in response to TCR signaling, produce much less IFN-gamma upon restimulation, and are deficient in activation-induced cell death (AICD). Additionally, GADD45gamma deficiencies caused reduced contact hypersensitivity in mice. Thus, GADD45gamma mediates activation of the p38 and JNK pathways and effector function of TH1 cells.

Overview

Integrity signals

Registry

Crossref · 10.1016/s1074-7613(01)00141-8

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 1 references

Research works printed but not linked: 34

  1. Abdollahi, 1991, Sequence and expression of a cDNA encoding MyD118, Oncogene, 6, 165
  2. Balomenos, 2000, The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development, Nat. Med., 6, 171, 10.1038/72272 · DOI
  3. Beadling, 1993, Isolation of interleukin 2-induced immediate-early genes, Proc. Natl. Acad. Sci. USA, 90, 2719, 10.1073/pnas.90.7.2719 · DOI
  4. Davis, 2000, Signal transduction by the JNK group of MAP kinases (Review), Cell, 103, 239, 10.1016/S0092-8674(00)00116-1 · DOI · Paper page
  5. Diehl, 2000, Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo, J. Exp. Med., 191, 321, 10.1084/jem.191.2.321 · DOI
  6. Dong, 2000, JNK is required for effector T-cell function but not for T-cell activation, Nature, 405, 91, 10.1038/35011091 · DOI
  7. Eisen, 1952, Elicitation of delayed allergic skin reactions with haptens, J. Exp. Med., 95, 473, 10.1084/jem.95.5.473 · DOI
  8. Fan, 1999, Cytokine response gene 6 induces p21 and regulates both cell growth and arrest, Oncogene, 18, 6573, 10.1038/sj.onc.1203054 · DOI
  9. Fornace, 1988, DNA damage-inducible transcripts in mammalian cells, Proc. Natl. Acad. Sci. USA, 85, 8800, 10.1073/pnas.85.23.8800 · DOI
  10. Fornace, 1992, Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest, Ann. NY Acad. Sci., 663, 139, 10.1111/j.1749-6632.1992.tb38657.x · DOI
  11. Gerwins, 1997, Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway, J. Biol. Chem., 272, 8288, 10.1074/jbc.272.13.8288 · DOI
  12. Harkin, 1999, Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1, Cell, 97, 575, 10.1016/S0092-8674(00)80769-2 · DOI
  13. Hollander, 1999, Genomic instability in Gadd45a-deficient mice, Nat. Genet., 23, 176, 10.1038/13802 · DOI
  14. Hubank, 1994, Identifying differences in mRNA expression by representational difference analysis of cDNA, Nucleic Acids Res., 22, 5640, 10.1093/nar/22.25.5640 · DOI
  15. Kearsey, 1995, Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1, Oncogene, 11, 1675
  16. Li, 2000, Role of the guanosine triphosphatase rac2 in T helper 1 cell differentiation, Science, 288, 2219, 10.1126/science.288.5474.2219 · DOI · Paper page
  17. Lu, 1998, Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice, Proc. Natl. Acad. Sci. USA, 95, 8233, 10.1073/pnas.95.14.8233 · DOI
  18. Lu, 1999, Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice, EMBO J., 18, 1845, 10.1093/emboj/18.7.1845 · DOI
  19. Nakayama, 1999, A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth, J. Biol. Chem., 274, 24766, 10.1074/jbc.274.35.24766 · DOI
  20. Rincon, 1998, Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway, EMBO J., 17, 2817, 10.1093/emboj/17.10.2817 · DOI
  21. Rincon, M., Conze, D., Weiss, L., Diehl, N.L., Fortner, K.A., Yang, D., Flavell, R.A., Enslen, H., Whitmarsh, A., and Davis, R.J. (2000). Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways? Immunol. Cell. Biol. 78, 166–175. · DOI
  22. Shaulian, 1999, Stress-induced JNK activation is independent of Gadd45 induction, J. Biol. Chem., 274, 29595, 10.1074/jbc.274.42.29595 · DOI
  23. Simon, 1990, Low dose ultraviolet B-irradiated Langerhans cells preferentially activate CD4+ cells of the T helper 2 subset, J. Immunol., 145, 2087, 10.4049/jimmunol.145.7.2087 · DOI
  24. Smith, 1994, Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen, Science, 266, 1376, 10.1126/science.7973727 · DOI
  25. Takekawa, 1998, A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK, Cell, 95, 521, 10.1016/S0092-8674(00)81619-0 · DOI
  26. Takekawa, 1997, A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways, EMBO J., 16, 4973, 10.1093/emboj/16.16.4973 · DOI
  27. Vairapandi, 1996, The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1, Oncogene, 12, 2579
  28. Wang, 1999, gadd45 is not required for activation of c-Jun N-terminal kinase or p38 during acute stress, J. Biol. Chem., 274, 29599, 10.1074/jbc.274.42.29599 · DOI
  29. Yang, 1998, Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2, Immunity, 9, 575, 10.1016/S1074-7613(00)80640-8 · DOI
  30. Yang, 2001, IL-18-stimulated GADD45beta required in cytokine-induced, but not TCR-induced, IFN-gamma production, Nat. Immunol., 2, 157, 10.1038/84264 · DOI
  31. Yi, 2000, Gadd45 family proteins are coactivators of nuclear hormone receptors, Biochem. Biophys. Res. Commun., 272, 193, 10.1006/bbrc.2000.2760 · DOI
  32. Zhan, 1999, Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45, Oncogene, 18, 2892, 10.1038/sj.onc.1202667 · DOI
  33. Zhang, 1997, Unequal death in T helper cell (Th)1 and Th2 effectors, J. Exp. Med., 185, 1837, 10.1084/jem.185.10.1837 · DOI
  34. Zhang, 1999, CR6, Oncogene, 18, 4899, 10.1038/sj.onc.1202885 · DOI

Cited by

See all 134

Metadata

Authors
Lu, B., Yu, H., Chow, C.-W., Li, B., Zheng, W.-P., Davis, R. J., & Flavell, R. A.
Venue
Immunity
Publisher
Elsevier BV
Published
2001-05
Volume
14
Issue
5
Pages
583-590
ISSN
1074-7613
DOI
10.1016/s1074-7613(01)00141-8
Cited by
134
References
1
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: GADD45γ Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector TH1 Cells. https://app.cochat.ai/papers/10.1016/s1074-7613(01)00141-8
The paper
Lu, B., Yu, H., Chow, C.-W., Li, B., Zheng, W.-P., Davis, R. J., & Flavell, R. A. (2001). GADD45γ Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector TH1 Cells. Immunity. https://doi.org/10.1016/s1074-7613(01)00141-8