The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation
Abstract
T helper 1 (T H 1) cells mediate cellular immunity, whereas T H 2 cells potentiate antiparasite and humoral immunity. We used a complementary DNA subtraction method, representational display analysis, to show that the small guanosine triphosphatase Rac2 is expressed selectively in murine T H 1 cells. Rac induces the interferon-γ (IFN-γ) promoter through cooperative activation of the nuclear factor kappa B and p38 mitogen-activated protein kinase pathways. Tetracycline-regulated transgenic mice expressing constitutively active Rac2 in T cells exhibited enhanced IFN-γ production. Dominant-negative Rac inhibited IFN-γ production in murine T cells. Moreover, T cells from Rac2 −/− mice showed decreased IFN-γ production under T H 1 conditions in vitro. Thus, Rac2 activates T H 1-specific signaling and IFN-γ gene expression.
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In the citing paper
“Rac2 also appears to be critical for T helper 1 lymphocyte differentiation (46).”
From Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency (2001) · cites this paper as [46]
In the citing paper
“The authors also showed that Rac2 is required for the production and release of IFN𝛄”
From The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function (2002) · cites this paper as [34]
In the citing paper
“Li et al. (34, 36) have shown that Rac2 is preferentially expressed in the Th1 subset of T cells.”
From The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function (2002) · cites this paper as [34]
In the citing paper
“Significantly, it was shown that this function of Rac2 depends on its ability to activate NF𝛋 B and p38”
From The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function (2002) · cites this paper as [34]
In the citing paper
“and that dominant negative Rac1N17 almost completely suppresses cytokine release by activated Th1 cells.”
From The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function (2002) · cites this paper as [34]
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Citations
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Cited by
Tiede, I., Fritz, G., Strand, S., Poppe, D., Dvorsky, R., Strand, D., Lehr, H. A., Wirtz, S., Becker, C., Atreya, R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16432 · Cited by 828
Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases
Gu, Y., Filippi, M.-D., Cancelas, J. A., Siefring, J. E., Williams, E. P., Jasti, A. C., Harris, C. E., Lee, A. W., Prabhakar, R., Atkinson, S. J., et al. (2003) · Science · doi:10.1126/science.1088485 · Cited by 510
Self-citationNF-κB as a therapeutic target in chronic inflammation: recent advances
Makarov, S. S. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01814-1 · Cited by 379
Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome
Le, L. Q., Kabarowski, J. H. S., Weng, Z., Satterthwaite, A. B., Harvill, E. T., Jensen, E. R., Miller, J. F., & Witte, O. N. (2001) · Immunity · doi:10.1016/s1074-7613(01)00145-5 · Cited by 215
Li, X., Bu, X., Lu, B., Avraham, H., Flavell, R. A., & Lim, B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1158-1171.2002 · Cited by 153
Self-citation
Metadata
- Authors
- Li, B., Yu, H., Zheng, W.-P., Voll, R., Na, S., Roberts, A. W., Williams, D. A., Davis, R. J., Ghosh, S., & Flavell, R. A.
- Venue
- Science
- Published
- 2000-06-23
- Volume
- 288
- Issue
- 5474
- Pages
- 2219-2222
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 141
- References
- 2
- Language
- en
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- Li, B., Yu, H., Zheng, W.-P., Voll, R., Na, S., Roberts, A. W., Williams, D. A., Davis, R. J., Ghosh, S., & Flavell, R. A. (2000). Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation. Science. https://doi.org/10.1126/science.288.5474.2219
