The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome
Open accessAbstract
Mice with a targeted disruption of the gene encoding a lymphoid-expressed orphan G protein-coupled receptor, G2A, demonstrate a normal pattern of T and B lineage differentiation through young adulthood. As G2A-deficient animals age, they develop secondary lymphoid organ enlargement associated with abnormal expansion of both T and B lymphocytes. Older G2A-deficient mice (>1 year) develop a slowly progressive wasting syndrome, characterized by lymphocytic infiltration into various tissues, glomerular immune complex deposition, and anti-nuclear autoantibodies. G2A-deficient T cells are hyperresponsive to TCR stimulation, exhibiting enhanced proliferation and a lower threshold for activation. Our findings demonstrate that G2A plays a critical role in controlling peripheral lymphocyte homeostasis and that its ablation results in the development of a novel, late-onset autoimmune syndrome.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, autoimmunity has been observed in mice in which phagocytes lack the G-protein coupled receptor G2A41, which is required for the response to lysophosphatidylcholine 42”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [42]
Citations
Cites
Tivol, E. A., Borriello, F., Schweitzer, A. N., Lynch, W. P., Bluestone, J. A., & Sharpe, A. H. (1995) · Immunity · doi:10.1016/1074-7613(95)90125-6 · Cited by 2,914
Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749
In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse
Schwarze, S. R., Ho, A. L., Vocero-Akbani, A. M., & Dowdy, S. F. (1999) · Science · doi:10.1126/science.285.5433.1569 · Cited by 2,418
Chemokines and Cell Migration in Secondary Lymphoid Organs
Cyster, J. G. (1999) · Science · doi:10.1126/science.286.5447.2098 · Cited by 1,029
Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959
Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off
Parijs, L. V., & Abbas, A. K. (1998) · Science · doi:10.1126/science.280.5361.243 · Cited by 958
REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS
Long, E. O. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.875 · Cited by 936
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
Bachmaier, K., Krawczyk, C. M., Kozieradzki, I., Kong, Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A. C., Itié, A., et al. (2000) · Nature · doi:10.1038/35003228 · Cited by 674
Cbl-b regulates the CD28 dependence of T-cell activation
Chiang, Y. J., Kole, H. K., Brown, K. E., Naramura, M., Fukuhara, S., Hu, R.-J., Jang, I. K., Gutkind, J. S., Shevach, E. M., & Gu, H. (2000) · Nature · doi:10.1038/35003235 · Cited by 626
Defective T Cell Differentiation in the Absence of Jnk1
Dong, C., Yang, D. D., Wysk, M., Whitmarsh, A. J., Davis, R. J., & Flavell, R. A. (1998) · Science · doi:10.1126/science.282.5396.2092 · Cited by 579
Cited by
Sorted by citations
Items 101–200 of 215
Control of inflammatory diseases by pathogens: lipids and the immune system
van der Kleij, D., & Yazdanbakhsh, M. (2003) · European Journal of Immunology · doi:10.1002/eji.200324340 · Cited by 48
Parks, B. W., Gambill, G. P., Lusis, A. J., & Kabarowski, J. H. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500085-jlr200 · Cited by 46
Self-citationMacrophage Efferocytosis in Cardiac Pathophysiology and Repair
Li, Y., Li, Q., & Fan, G. (2020) · Shock · doi:10.1097/shk.0000000000001625 · Cited by 47
Sheng, Y., Hu, W., Chen, S., & Zhu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1275203 · Cited by 50
N ‐Palmitoylglycine and other N ‐acylamides activate the lipid receptor G2A/GPR132
Foster, J. R., Ueno, S., Chen, M. X., Harvey, J., Dowell, S. J., Irving, A. J., & Brown, A. J. (2019) · Pharmacology Research & Perspectives · doi:10.1002/prp2.542 · Cited by 44
Compartmentalization of human natural killer cells
Maghazachi, A. A. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.07.036 · Cited by 44
Bolick, D. T., Whetzel, A. M., Skaflen, M. D., Deem, T. L., Lee, J., & Hedrick, C. C. (2007) · Circulation Research · doi:10.1161/01.res.0000258877.57836.d2 · Cited by 43
Srivastava, R., Yu, S., Parks, B. W., Black, L. L., & Kabarowski, J. H. S. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27764 · Cited by 41
Self-citationThe Lysophosphatidylserines—An Emerging Class of Signalling Lysophospholipids
Shanbhag, K., Mhetre, A. B., Khandelwal, N., & Kamat, S. S. (2020) · The Journal of Membrane Biology · doi:10.1007/s00232-020-00133-2 · Cited by 40
Osthues, T., Zimmer, B., Rimola, V., Klann, K., Schilling, K., Mathoor, P., Angioni, C., Weigert, A., Geißlinger, G., Münch, C., et al. (2020) · Cells · doi:10.3390/cells9071740 · Cited by 40
Role of the CC Chemokine receptor 9/TECK interaction in apoptosis
Youn, B., Yu, K.-Y., Oh, J. H., Lee, J., Lee, T.-H., & Broxmeyer, H. E. (2002) · APOPTOSIS · doi:10.1023/a:1015320321511 · Cited by 37
Foulds, L. M., Boysen, R. I., Crane, M., Yang, Y., Muir, J. A., Smith, A. I., de Kretser, D. M., Hearn, M. T. W., & Hedger, M. P. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.107.064386 · Cited by 36
Two ligands for a GPCR, proton vs lysolipid1
Im, D. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00237.x · Cited by 35
Molecular mechanism of inflammatory pain
Su, Y.-S. (2014) · World Journal of Anesthesiology · doi:10.5313/wja.v3.i1.71 · Cited by 35
Yasutomo, K. (2003) · British journal of rheumatology · doi:10.1093/rheumatology/keg081 · Cited by 35
Cho, H., & Kehrl, J. H. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)86009-2 · Cited by 34
Wedel, S., Osthues, T., Zimmer, B., Angioni, C., Geißlinger, G., & Sisignano, M. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114953 · Cited by 33
Wirasinha, R. C., Vijayan, D., Smith, N. J., Parnell, G. P., Swarbrick, A., Brink, R. A., King, C., Stewart, G. J., Booth, D. R., & Batten, M. (2017) · Immunology and Cell Biology · doi:10.1111/imcb.1031 · Cited by 32
Kepp, O., Gdoura, A., Martins, I., Panaretakis, T., Schlemmer, F., Tesnière, A., Fimia, G. M., Ciccosanti, F., Burgevin, A., Piacentini, M., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.15.12459 · Cited by 30
Current Understanding of the Mechanisms for Clearance of Apoptotic Cells—A Fine Balance
Hawkins, L., & Devitt, A. (2013) · Journal of Cell Death · doi:10.4137/jcd.s11037 · Cited by 28
Légrádi, Á., Chiţu, V., Szukacsov, V., Fajka‐Boja, R., Szücs, K. S., & Monostori, É. (2003) · Immunology Letters · doi:10.1016/j.imlet.2003.10.009 · Cited by 28
Cheung, Y.-H., Loh, C., Pau, E., Kim, J. J., & Wither, J. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.10.005 · Cited by 27
Gα13 Mediates a Signal That Is Essential for Proliferation and Survival of Thymocyte Progenitors
Coffield, V. M., Helms, W. S., Jiang, Q., & Su, L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040944 · Cited by 27
Lysophosphatidylserine: A Signaling Lipid with Implications in Human Diseases
Chakraborty, A., & Kamat, S. S. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00701 · Cited by 24
Song, M. H., Gupta, A., Kim, H. O., & Oh, K. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.4.193 · Cited by 25
Lunjani, N., Ambikan, A. T., Hlela, C., Levin, M., Mankahla, A., Heldstab‐Kast, J. I., Boonpiyathad, T., Tan, G., Altunbulakli, C., Gray, C., et al. (2024) · Allergy · doi:10.1111/all.15832 · Cited by 25
Dysregulated homeostasis of target tissues or autoantigens - A novel principle in autoimmunity
Petersen, F., Yue, X., Riemekasten, G., & Yu, X. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.04.006 · Cited by 24
Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors
Klatt, W., Wallner, S., Brochhausen, C., Stolwijk, J. A., & Schreml, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-71700-9 · Cited by 24
Having an Old Friend for Dinner: The Interplay between Apoptotic Cells and Efferocytes
Lam, A. L., & Heit, B. (2021) · Cells · doi:10.3390/cells10051265 · Cited by 22
Kamanna, V. S., Bassa, B. V., Ganji, S. H., & Roh, D. D. (2005) · PubMed · doi:10.14670/hh-20.603 · Cited by 24
Hui, X., Xue, M., Ren, Y., Chen, Y., Chen, X., Farooq, M. A., Ji, Y., Zhan, W., Huang, Y., Du, B., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr9395 · Cited by 23
Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells
Helms, W. S., Jeffrey, J., Holmes, D. A., Townsend, M. B., Clipstone, N. A., & Su, L. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0206120 · Cited by 23
Efferocytosis: the art of cellular clearance and novel perspectives in disease therapy
Li, G., Xu, J., Tian, X., Xiao, J., Long, J., Chen, Y., Shen, W., & Zhao, S. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02484-7 · Cited by 29
Mezger, M., von Bonin, M., Keßler, T., Gebhardt, F., Einsele, H., & Loeffler, J. (2009) · Viral Immunology · doi:10.1089/vim.2009.0011 · Cited by 22
The G protein–coupled receptor G2A
Johnson, L. E., Elias, M. S., Bolick, D. T., Skaflen, M. D., Green, R. M., & Hedrick, C. C. (2008) · Hepatology · doi:10.1002/hep.22433 · Cited by 22
Removal of phospholipid contaminants through precipitation of glycosylphosphatidylinositols
Azzouz, N., Shams-Eldin, H., & Schwarz, R. Τ. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.04.030 · Cited by 21
Efferocytosis and Its Role in Rheumatic Diseases
Tang, X., Peng, Y., Jiang, Z., Yu, B., Peng, D., Xie, X., Li, F., & Ge, Y. L. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43268 · Cited by 21
Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals
Huang, Y.-H., Su, Y.-S., Chang, C.-J., & Sun, W. (2016) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2016.1155064 · Cited by 20
Tao, Q., Lloyd, R. B., Tanadini‐Lang, S., Houston, D. W., Zorn, A. M., & Wylie, C. (2005) · Development · doi:10.1242/dev.01866 · Cited by 20
Biomarker candidates for the detection of an infectious etiology of febrile neutropenia
Richter, M. E. A., Neugebauer, S., Engelmann, F., Hagel, S., Ludewig, K., Rosée, P. G. L., Sayer, H. G., Hochhaus, A., von Lilienfeld‐Toal, M., Bretschneider, T., et al. (2015) · Infection · doi:10.1007/s15010-015-0830-6 · Cited by 19
Deletion of p21 (WAF-1/Cip1) Does Not Induce Systemic Autoimmunity in Female BXSB Mice
Lawson, B. R., Kono, D. H., & Theofilopoulos, A. N. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5928 · Cited by 19
Gαs‐coupled GPCR s GPR 65 and GPR 174. Downers for immune responses
Robert, R., & Mackay, C. R. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12027 · Cited by 18
Matsuda, A., Yamada, M., Matsumoto, S., Sakurazawa, N., Yamada, T., Matsutani, T., Miyashita, M., & Uchida, E. (2018) · Surgery Today · doi:10.1007/s00595-018-1675-2 · Cited by 18
Deletion of the G2A receptor fails to attenuate experimental autoimmune encephalomyelitis
Osmers, I., Smith, S. S., Parks, B. W., Yu, S., Srivastava, R., Wohler, J. E., Barnum, S. R., & Kabarowski, J. H. S. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.11.008 · Cited by 18
Self-citationMDSHEIKH, A., Ochi, H., Manabe, A., & Masuda, J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.09.017 · Cited by 18
Family 1 G protein-coupled receptor function in the CNS Insights from gene knockout mice
Karasinska, J. M. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00221-7 · Cited by 18
Ge, X., Wang, S., Li, Z., Yu, J., Liu, B., Wang, R., Bu, S., wan, N., Wang, Y., Dai, C., et al. (2025) · Advanced Science · doi:10.1002/advs.202500141 · Cited by 18
Effect of CYP3A4 on liver injury induced by triptolide
Xiao, X., Zhang, T., Huang, J., Zhao, Q., & Li, F. (2020) · Biomedical Chromatography · doi:10.1002/bmc.4864 · Cited by 17
Efferocytosis: Current status and future prospects in the treatment of autoimmune diseases
Li, Q., Liu, H., Yin, G., & Xie, Q. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28399 · Cited by 17
Grossmayer, G. E., Keppeler, H., Boeltz, S., Janko, C., Rech, J., i, M. H., Lauber, K., & Munoz, L. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01876 · Cited by 16
Bercher, M. R., Hanson, B. J., van Staden, C., Wu, K., Ng, G., & Lee, P. H. (2009) · Assay and Drug Development Technologies · doi:10.1089/adt.2008.179 · Cited by 15
Inhoffen, J., Tuma‐Kellner, S., Straub, B. K., Stremmel, W., & Chamulitrat, W. (2015) · Cancers · doi:10.3390/cancers7040901 · Cited by 15
Molecular Suicide Notes: Last Call from Apoptosing Cells
Peter, C., Wesselborg, S., & Lauber, K. (2009) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjp045 · Cited by 14
Li, R., Zhao, Y., Qin, F., Zhao, Y., Xiao, X.-R., Cao, W., Fan, M., Wang, S., Wu, Y., Wang, B., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153979 · Cited by 14
Harley, I. T. W., Allison, K., & Scofield, R. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.953439 · Cited by 15
Experimental Use of Murine Lupus Models
Peng, S. L. (2004) · Humana Press eBooks · doi:10.1385/1-59259-805-6:227 · Cited by 13
Bond, J., Domaschenz, R., Román-Trufero, M., Sabbattini, P. M. R., Ferreirós-Vidal, I., Gerrard, G., Asnafi, V., Macintyre, E. A., Merkenschlager, M., & Dillon, N. (2016) · Oncotarget · doi:10.18632/oncotarget.11688 · Cited by 14
GENES AND GENETICS OF MURINE LUPUS
Kono, D. H., Baccalà, R., & Theofilopoulos, A. N. (2004) · Elsevier eBooks · doi:10.1016/b9-78-012433-9/01950-0119 · Cited by 13
Zhang, M., Wei, J., Sun, Y., He, C., Ma, S., Pan, X., & Zhu, X. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.03.008 · Cited by 15
Class A Orphans (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database
Alexander, S. P. H., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Eguchi, S., Harmar, A. J., Holliday, N. D., Jensen, R. T., et al. (2019) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f16/2019.5 · Cited by 12
Meta‐Omics‐ and Metabolic Modeling‐Assisted Deciphering of Human Microbiota Metabolism
Sieow, B. F., Nurminen, T. J., Ling, H., & Chang, M. W. (2019) · Biotechnology Journal · doi:10.1002/biot.201800445 · Cited by 12
Murakami, N., Hashidate, T., 原山, 武., Yokomizo, T., Shimizu, T., & Nakamura, M. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01360.x · Cited by 12
Experimental Use of Mouse Models of Systemic Lupus Erythematosus
Peng, S. L. (2012) · Methods in molecular biology · doi:10.1007/978-1-60761-720-4_7 · Cited by 12
Li, H., Jang, J. H., Jung, J., Shin, J., Park, C., Kim, Y.-J., Ahn, W.-G., Nam, J., Hong, C.-W., Lee, J., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700783 · Cited by 11
Self-citationDefective clearance of nucleosomes and systemic lupus erythematosus
Maekawa, Y., & Yasutomo, K. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)02084-1 · Cited by 11
Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage
Mizukami, H., Mi, Y., Wada, R., Kono, M., Yamashita, T., Liu, Y., Werth, N., Sandhoff, R., Sandhoff, K., & Proia, R. L. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200214530 · Cited by 10
Briand‐Mésange, F., Gennero, I., Salles, J., Trudel, S., Dahan, L., Ausseil, J., Payrastre, B., Salles, J., & Chap, H. (2024) · Molecules · doi:10.3390/molecules29153694 · Cited by 10
Jakobsson, J. E., Menezes, J., Krock, E., Hunt, M. A., Carlsson, H., Vaivade, A., Emami Khoonsari, P., Agalave, N. M., Sandström, A., Kadetoff, D., et al. (2025) · The Journal of Pain · doi:10.1016/j.jpain.2025.105331 · Cited by 9
Lactate and lactylation in tumor immunity
Liu, S., Sun, L., Chen, S., & Lan, P. (2025) · Frontiers of Medicine · doi:10.1007/s11684-025-1148-0 · Cited by 9
Das, J., Arora, P., Gracias, D. T., Praveen, A., Raj, B. P. J., Martin, E., & Pal, R. (2008) · European Journal of Immunology · doi:10.1002/eji.200838624 · Cited by 9
Peter, C., Wesselborg, S., & Lauber, K. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9293-0_3 · Cited by 9
Steffan, B. N., Calise, D. G., Park, S. C., Niu, M., Yang, J., Hammock, B. D., Jones, M., Steele, C. H., & Keller, N. P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1173544 · Cited by 8
G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia
Su, Y.-S., Huang, Y., Wong, J., Lee, C., Hsieh, W.-S., & Sun, W. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-1000-3 · Cited by 8
Class A Orphans (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database
Alexander, S. P. H., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Singh, K. D., Eguchi, S., Harmar, A. J., Holliday, N. D., et al. (2020) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f16/2020.5 · Cited by 8
Kono, D. H., & Theofilopoulos, A. N. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374994-9.10004-x · Cited by 8
Tackling the complexities of orphan GPCR ligand discovery with rationally assisted approaches
So, S. S., Ngo, T., Keov, P., Smith, N. J., & Kufareva, I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816228-6.00016-7 · Cited by 9
Structure-activity relationship of lysophosphatidylcholines in HL-60 human leukemia cells.
Lee, E., Yun, M.-R., Wang, W., Jung, J. H., & Im, D. (2004) · PubMed · Cited by 7
Class A Orphans in GtoPdb v.2023.1
Alexander, S. P. H., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Singh, K. D., Eguchi, S., Harmar, A. J., Holliday, N. D., et al. (2023) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f16/2023.1 · Cited by 6
Shao, Y., Mei, Y., Tan, Y., Yang, M., & Wu, H. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01398-7 · Cited by 5
Proton-sensing G-protein–coupled receptors and their physiological roles
Tomura, H., Mogi, C., Sato, K., & Okajima, F. (2010) · Folia Pharmacologica Japonica · doi:10.1254/fpj.135.240 · Cited by 5
Two zebrafish G2A homologs activate multiple intracellular signaling pathways in acidic environment
一條, 祐., Mochimaru, Y., Azuma, M., Satou, K., Negishi, J., Nakakura, T., Oshima, N., Mogi, C., Sato, K., Matsuda, K., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.11.075 · Cited by 4
Whole body deletion of Gpr68 does not change hematopoietic stem cell function
He, X., Hawkins, C., Lawley, L., Freeman, K. J., Phan, T. M., Zhang, J., Xu, Y., & Fang, J. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.101869 · Cited by 4
Function and Signaling of the pH-Sensing G Protein-Coupled Receptors in Physiology and Diseases
Dong, L., Li, Z., & Yang, L. V. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1683-2_4 · Cited by 4
KLF14 and SREBF-1 Binding Site Associations with Orphan Receptor Promoters in Metabolic Syndrome
Garcia-Coste, J. J., Villafaña, S., Aguayo-Cerón, K. A., Vargas‐De‐León, C., & Romero‐Nava, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072849 · Cited by 3
Uwamizu, A., Shinjo, Y., Omi, J., Tatstumi, M., Kano, K., Makide, K., Kitamura, H., Okudaira, M., Satoh, K., Fukami, F., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112420 · Cited by 3
Genetics and humoral responses of the immune system to Aspergillus fumigatus
Sanya, D. R. A., Jayachandran, K., & Onésime, D. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.06.007 · Cited by 3
Class A Orphans in GtoPdb v.2021.3
Alexander, S. P. H., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Singh, K. D., Eguchi, S., Harmar, A. J., Holliday, N. D., et al. (2021) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f16/2021.3 · Cited by 2
Peripheral Tolerance of T Cells in the Mouse
Heissmeyer, V., Tanasă, B., & RAO, A. (2007) · Elsevier eBooks · doi:10.1016/b978-012369454-6/50088-1 · Cited by 2
Breaking the one‐site myth: the multifaceted world of proton sensing in GPCR s
Agrawal, M., Singh, S. K., Baidya, M., & Kumari, P. (2025) · FEBS Journal · doi:10.1111/febs.70145 · Cited by 1
Class A Orphans in GtoPdb v.2022.3
Alexander, S. P. H., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Singh, K. D., Eguchi, S., Harmar, A. J., Holliday, N. D., et al. (2022) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f16/2022.3 · Cited by 1
Class A Orphans (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Alexander, S. P. H., Battey, J., Benson, H. E., Benya, R. V., Bonner, T. I., Davenport, A. P., Eguchi, S., Harmar, A. J., Holliday, N. D., Jensen, R. T., et al. (2019) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f16/2019.4 · Cited by 1
Phenotypic and Functional Characteristics of the IgM-IgD+ Naive B Cell Population in SLE Patients
Kim, J. J. (2010) · TSpace (University of Toronto) · Cited by 1
Accumulation of Self-Antigens in Systemic Lupus Erythematosus
Yasutomo, K. (2006) · Springer eBooks · doi:10.1007/0-387-24534-0_20
Baudhuin, L. M., Xiao, Y., & Xu, Y. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50525-8
The role of annexin A1 in secondary necrosis
Blume, K. (2011)
Crossprocessing and Crosspresentation
Škoberne, M., & Bhardwaj, N. (2006) · Wiley eBooks · doi:10.1002/9783527619696.ch22
(Auto)Phagocytosis in Atherosclerosis: Implications for Plaque Stability and Therapeutic Challenges
Dorien, M., Meyer, G. R. Y. D., & Martinet, W. (2012) · InTech eBooks · doi:10.5772/25335
Lauber, K., & Wesselborg, S. (2006) · Wiley eBooks · doi:10.1002/9783527619665.ch24
Building Clinical Trust in Automated Knowledge Acquisition
Shillabeer, A. G. (2008) · InTech eBooks · doi:10.5772/6408
Effects of Proton on Lysolipid-induced Actions in OGR1-subfamily GPCRs
Lim, S.-M., & Im, D. (2007) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2007.15.1.052
Metadata
- Authors
- Le, L. Q., Kabarowski, J. H. S., Weng, Z., Satterthwaite, A. B., Harvill, E. T., Jensen, E. R., Miller, J. F., & Witte, O. N.
- Affiliations
- University of California, Los Angeles (US)
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Witte, Owen N
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 14
- Issue
- 5
- Pages
- 561-571
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2095533402
- Cited by
- 215
- References
- 50
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 7
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca076204-05)
- National Cancer Institute (CA76204, T32 CA090576)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- G2A, orphan G protein-coupled receptor, knockout mice, lymphocyte homeostasis, B cell hyperactivation, cachexia, immune complex deposition, antinuclear antibodies, aging
- MeSH terms
- Animals, Autoimmune Diseases, B-Lymphocytes, Cell Division, Female, Lymph Nodes, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptors, Antigen, T-Cell, Receptors, Cell Surface, T-Lymphocytes, Time Factors, Autoimmunity, Mice, Knockout, Cell Cycle Proteins, GTP-Binding Proteins, Receptors, G-Protein-Coupled, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review