Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

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In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

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Chemokines and Cell Migration in Secondary Lymphoid Organs

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Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

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Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

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REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

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Cbl-b regulates the CD28 dependence of T-cell activation

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Defective T Cell Differentiation in the Absence of Jnk1

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Molecular Mimicry and Autoimmunity

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Impaired Fas Response and Autoimmunity in Pten +/− Mice

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Signal transduction by the TCR for antigen

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The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation

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Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

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Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

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Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

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Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

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Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

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Regulation of T cell activation, anxiety, and male aggression by RGS2

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Mass spectrometry: A tool for the identification of proteins separated by gels

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Signaling Takes Shape in the Immune System

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CD5 Negatively Regulates the T-Cell Antigen Receptor Signal Transduction Pathway: Involvement of SH2-Containing Phosphotyrosine Phosphatase SHP-1

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Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81

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INTEGRATION OF T CELL RECEPTOR–DEPENDENT SIGNALING PATHWAYS BY ADAPTER PROTEINS

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Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation.

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Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.

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G(α)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines

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T Cell Progenitors Emerge Earlier Than B Cell Progenitors in the Murine Fetal Liver

Kawamoto, H., Ikawa, T., Ohmura, K., Fujimoto, S., & Katsura, Y. (2000) · Immunity · doi:10.1016/s1074-7613(00)80196-x · Cited by 157

A DNA damage and stress inducible G protein-coupled receptor blocks cells in G 2 /M

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Lymphocyte homeostasis

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Identification of a Putative G Protein-Coupled Receptor Induced during Activation-Induced Apoptosis of T Cells

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Anatomy of autoantibody production: Dominant localization of antibody-producing cells to T cell zones in fas-deficient mice

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Regulators of G Protein Signaling Exhibit Distinct Patterns of Gene Expression and Target G Protein Specificity in Human Lymphocytes

Beadling, C., Druey, K. M., Richter, G. H. S., Kehrl, J. H., & Smith, K. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2677 · Cited by 102

Pregenomic Comparative Analysis betweenBordetella bronchisepticaRB50 andBordetella pertussisTohama I in Murine Models of Respiratory Tract Infection

Harvill, E. T., Cotter, P. A., & Miller, J. F. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.6109-6118.1999 · Cited by 95

GENETICS OF SYSTEMIC LUPUS ERYTHEMATOSUS

Sullivan, K. E. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70137-x · Cited by 89

Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ “knock-in” strategy

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G2A is an oncogenic G protein-coupled receptor

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Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways

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Direct genetic demonstration of Gα13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement

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Cloning, Characterization, and Mapping of Human Homolog of Mouse T-Cell Death-Associated Gene

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Fas (CD95)-Dependent Cell-Mediated Immunity toListeria monocytogenes

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Long-term culture of murine bone marrow precursors of B lymphocytes

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Negative regulation of antigen receptor signaling in lymphocytes

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Signal transduction in T lymphocytes.

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Gα16 protein expression is up‐ and down‐regulated following T‐cell activation: disruption of this regulation impairs activation‐induced cell responses

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NZB Mice Exhibit a Primary T Cell Defect in Fetal Thymic Organ Culture

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In situ lacZ retrovirus-marked lymphocytes define a B cell microenvironment in the lymph node medulla.

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Untitled work

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Immunogenic and tolerogenic cell death

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Mammalian G Proteins and Their Cell Type Specific Functions

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Free Fatty Acid Receptors in Health and Disease

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Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

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The clearance of dead cells by efferocytosis

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Receptor Linked to an Autoimmune Disease

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Deletion of the G2A receptor fails to attenuate experimental autoimmune encephalomyelitis

Osmers, I., Smith, S. S., Parks, B. W., Yu, S., Srivastava, R., Wohler, J. E., Barnum, S. R., & Kabarowski, J. H. S. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.11.008 · Cited by 18

Mice Lacking the p53-Effector Gene Gadd45a Develop a Lupus-Like Syndrome

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#91 Immune and autoimmune effects of the environmental antiandrogen, DDE

Lubinski, A. L., Kluka, E., Webb, A., & Viselli, S. M. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.10.098

Inhibition of abnormal T cell development and autoimmunity in gld mice by transgenic T cell receptor β chain

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