STAT3 is required for Flt3L-dependent dendritic cell differentiation
Open accessAbstract
The signals that control decisions of progenitor commitment involve the interplay of both cytokines and transcription factors. Flt3L has emerged as a potential regulator of dendritic cell (DC) development, but regulation of HSC commitment to the DC lineage remains poorly understood. Our central finding is the identification of STAT3 activation as a checkpoint of Flt3L-regulated DC development. Deletion of STAT3 caused profound deficiency in the DC compartment and abrogated Flt3L effects on DC development. DC derivation by Flt3L revealed a normal HSC pool, a 2- to 3-fold accumulation of CLP/CMP, but absence of common DC precursors as well as their DC progeny in STAT3-deficient mice. The formation of CMP and CLP represents the first decisive lineage commitment step, and in this regard we provide evidence that commitments of CLP/CMP to the DC lineage strictly depend on the interplay of both Flt3L and STAT3 activation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
STAT3 knockout in hematopoietic-derived cells impairs dendritic cell function with defective transition of CMP/CLP to common DC precursors.
“Impaired DC function: defective transition of CMP/CLP to common DC precursors”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Laouar et al., 2003
STAT3 plays major roles in immature dendritic cell development and function, affecting both plasmacytoid DCs and conventional DCs.
“STAT3 also plays major roles in immature DC development and function”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Laouar et al., 2003
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 57 · Cited by 334
- Authors
- Laouar, Y., Welte, T., Fu, X.-Y., & Flavell, R. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Yale University (US)
- Corresponding author
- Fu, Xin-Yuan
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 19
- Issue
- 6
- Pages
- 903-912
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2065086280
- Cited by
- 334
- References
- 57
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 17 · 2018: 14 · 2017: 17 · 2016: 15 · 2015: 15 · 2014: 26 · 2013: 19 · 2012: 16
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI-34522, R01AI034522)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- STAT3, Flt3L, dendritic cell differentiation, dendritic cell development, hematopoietic stem cells, lineage commitment, common lymphoid progenitors, common myeloid progenitors, STAT3 deficiency, cytokine signaling
- MeSH terms
- Animals, Cell Differentiation, Dendritic Cells, DNA-Binding Proteins, Homeostasis, Membrane Proteins, Trans-Activators, Granulocyte-Macrophage Colony-Stimulating Factor, STAT3 Transcription Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
