Back to central tolerance

Mathis, Diane; Benoist, Christophe

doi:10.1016/s1074-7613(04)00111-6

Cited by 198T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesDiabetes and associated disorders

Back to central tolerance

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Mathis, Diane, Benoist, Christophe·2004·Immunity

DOI 10.1016/s1074-7613(04)00111-6

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Abstract

The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human autoimmune diseases, including APECED and type 1 diabetes.

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True pathogenic antigens causing the breakdown have not been identified for many autoimmune diseases, including rheumatoid arthritis and other tissue-specific disorders.
“However, true pathogenic antigens causing the breakdown have not been identified for many autoimmune diseases, including RA and other tissue-specific disorders (229–231).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [231]

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Nobrega, C., Cardona, P., Roque, S., Perpétua Pinto Do, O., Appelberg, R., & Correia-Neves, M. (2007) · Microbes and infection · doi:10.1016/j.micinf.2007.08.006 · Cited by 44
“Thymic selection aims at generating a pool of useful T cells: T cells whose T cells receptors are able to recognize and become activated when interacting with self major histocompatibility complex molecules (MHC) expressing foreign peptides (self-restricted), but that are tolerant to self-MHC molecules expressing self…”
Background
Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras
Cohen, M. A., Zhang, S., Sengupta, S., Ma, H.-T., Bell, G. W., Horton, B., Sharma, B., George, R., Spranger, S., & Jaenisch, R. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.02.001 · Cited by 43 · see citing works
“Immune tolerance may develop because of central thymic tolerance or because of peripheral tolerance (Mathis and Benoist, 2004; Xing and Hogquist, 2012).”
Background
The vicious cycle of apoptotic β‐cell death in type 1 diabetes
Kaminitz, A., Stein, J., Yaniv, I., & Askenasy, N. (2007) · doi:10.1038/sj.icb.7100093 · Cited by 41
Evaluation of Natural Regulatory T Cells in Subjects with Selective IgA Deficiency: From Senior Idea to Novel Opportunities
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Tolerance to Proinsulin-2 Is Due to Radioresistant Thymic Cells
Faideau, B., Lotton, C., Lucas, B., Tardivel, I., Elliott, J. F., Boîtard, C., & Carel, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.53 · Cited by 37 · see citing works
Dendritic Cell-Based Tumor Vaccines and Antigen Presentation Attenuators
Evel-Kabler, K., & Chen, S. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.02.009 · Cited by 32 · see citing works
“There are many explanations for the ineffectiveness of DC tumor vaccines, including inefficient antigen loading methods; DC maturation state and trafficking ability; the heterogeneous nature of DC populations; tumor antigen mutations; tumor-mediated immunosuppression; self-tolerance of autoreactive, low-avidity T cell…”
Background
Immunological memory stabilizing autoreactivity.
Manz, R., Moser, K., Burmester, G., Radbruch, A., & Hiepe, F. (2006) · Current Topics in Microbiology and Immunology · doi:10.1007/3-540-29714-6_12 · Cited by 34 · see citing works
“Autoimmune diseases affecting humans and animals are genetically complex [1, 2].”
Background
Toll-like receptors and IFN-α: partners in autoimmunity
Colonna, M. (2006) · doi:10.1172/jci29879 · Cited by 32
Inhibition of HLA-DM Mediated MHC Class II Peptide Loading by HLA-DO Promotes Self Tolerance
Denzin, L. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00465 · Cited by 30 · see citing works
“CD4 T cells are immunologically tolerant of self-pMHCII complexes since inappropriate T cell activation contributes to the development of autoimmune disease (1).”
Background
CD4+T Lymphocytes
Mowat, A. M., & Garside, P. (2010) · doi:10.1002/9780470688618.taw0101 · Cited by 8 · see citing works
Peripheral T cells in the thymus: have they just lost their way or do they do something?
Bosco, N., Kirberg, J., Ceredig, R., & Agenès, F. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2008.83 · Cited by 28 · see citing works
Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity
Geenen, V., Bodart, G., Henry, S., Michaux, H., Dardenne, O., Charlet-Renard, C., Martens, H., & Hober, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00187 · Cited by 27 · see citing works
Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin
Danzl, N., Donlin, L. T., & Alexandropoulos, K. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20092384 · Cited by 27 · see citing works
“, 2008), it has been proposed that extensive interactions between mTECs and thymocytes are required for establishment of central tolerance (Kyewski and Klein, 2006; Mathis and Benoist, 2004).”
Background
Immune Tolerance Induction by Integrating Innate and Adaptive Immune Regulators
Suzuki, J., Ricordi, C., & Chen, Z. (2010) · Cell Transplantation · doi:10.3727/096368909x480314 · Cited by 25 · see citing works
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Use of Anti‐CD3 Monoclonal Antibody to Induce Immune Regulation in Type 1 Diabetes
Bisikirska, B. C., & Herold, K. C. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1337.001 · Cited by 26 · see citing works
Targeting T Cell-Specific Costimulators and Growth Factors in a Model of Autoimmune Hemolytic Anemia1
Hoyer, K., Wolslegel, K., Dooms, H., & Abbas, A. (2007) · Journal of Immunology · doi:10.4049/jimmunol.179.5.2844 · Cited by 25
Age-related deregulation of Aire and peripheral tissue antigen genes in the thymic stroma of non-obese diabetic (NOD) mice is associated with autoimmune type 1 diabetes mellitus (DM-1)
Fornari, T. A., Donate, P. B., Macedo, C., Marques, M. M., Magalhães, D. A., & Passos, G. A. S. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0464-z · Cited by 24 · see citing works
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Geenen, V. G. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-020-00831-y · Cited by 31 · see citing works
1,25-dihydroxyvitamin D3 down-modulates the production of proinflammatory cytokines and nitric oxide and enhances the phosphorylation of monocyte-expressed STAT6 at the recent-onset type 1 diabetes.
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Diabetes Is Predicted by the β Cell Level of Autoantigen1
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Determinants of immunogenic response to protein therapeutics
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Authors: Mathis, D., & Benoist, C.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Benoist, Christophe
ORCID: Mathis, Diane
Benoist, Christophe
Venue: Immunity
Publisher: Elsevier BV
Published: 2004-05
Volume: 20
Issue: 5
Pages: 509-516
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/s1074-7613(04)00111-6
OpenAlex: W2047784036
Cited by: 198
References: 0
Citations by year: 2026: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 9 · 2013: 11 · 2012: 11
FWCI: 2.27
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3364 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: central tolerance, peripheral tolerance, immune tolerance, regulatory T cells, autoimmune disease, APECED, type 1 diabetes, autoimmunity
MeSH terms: AIRE Protein, Animals, Autoimmune Diseases, Cell Differentiation, Humans, Immune Tolerance, Lymphocyte Activation, T-Lymphocytes, Thymus Gland, Transcription Factors

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