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Open accessAbstract
The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human autoimmune diseases, including APECED and type 1 diabetes.
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“However, true pathogenic antigens causing the breakdown have not been identified for many autoimmune diseases, including RA and other tissue-specific disorders (229–231).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [231]
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Kim, E. S., Jung, H., Nam-Goong, I., Woo, S., Choi, J. I. L., & Kim, Y.-I. (2006) · doi:10.3803/jkes.2006.21.2.116 · Cited by 2
“이 과정에서 민감성과 특이성을 동시에 갖추지 않으면 면역기능 저하에 의한 감염 이 증가하거나, 비특이적인 T 세포 반응에 의해 자가항원에 대한 면역반응을 일으켜 면역질환을 유발하게 된다[1].”
Alexandropoulos, K., & Danzl, N. (2012) · Immunologic research · doi:10.1007/s12026-012-8301-y · Cited by 1
Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis.
Gudmundsdottir, J., Thorgeirsdottir, S., Lundbäck, V., Göngrich, C., Framme, J., Kindgren, E., Rydenman, K., Ludviksson, B., Bjarnadottir, H., Rúnarsdóttir, S., et al. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109277 · Cited by 1
Kim, E. S., Jung, H., Choi, J. I. L., Nam-Goong, I. S., Hong, S. H., & Kim, Y.-I. (2007) · doi:10.3803/jkes.2007.22.5.332 · Cited by 1
CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance
Fallarino, F., Vacca, C., Volpi, C., Pallotta, M. T., Gizzi, S., Grohmann, U., & Puccetti, P. (2008) · doi:10.1007/978-3-7643-8296-4_7 · Cited by 1
CHAPTER 38 – Polyendocrine Syndromes
Peterson, P. (2006) · Elsevier eBooks · doi:10.1016/b978-012595961-2/50041-x · Cited by 1
Autoimmunity in Type 1 Diabetes mellitus
Achenbach, P., & Ziegler, A. (2005) · KARGER eBooks · doi:10.1159/000085778
Introductory Chapter: Thymus - The Central Self-Tolerance System
Saghazadeh, A., & Rezaei, N. (2020) · Thymus · doi:10.5772/intechopen.90491
Modulation of IKK/NF-B signaling iin pancreatic ß-cells induces diabetes
Salem, H. (2013) · doi:10.18725/oparu-2629
“The importance of central tolerance can be evidenced by the fact that significant percentage of patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) develops autoimmune diabetes (Mathis and Benoist, 2004).”
BackgroundO papel dos microRNAs de células T na susceptibilidade/resistência a artrite reumatóide experimental
Yabuta, P. B. D. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2012.tde-16022012-150623
Dresch, C. (2007) · Molecular Therapy · doi:10.1016/s1525-0016(16)44467-9
T cell tolerance to the skin: a central role for central tolerance
Schuler, P., Contassot, E., & Huard, B. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0062-7
“First, the very same mTEC have the unique property to express TRA, in a socalled promiscuous fashion, due to the expression of the specific transcription factor autoimmune regulator [3, 4].”
BackgroundVitamin A and its relationship with insulin secretion and diabetes mellitus: a review
Vial-Dahmer, D. D. S., Spada, E. C. D. L., Neto, E. W. A., da Silva, W. B., Latorraca, M. Q., & de França, S. A. (2026) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202620250426
Autoimmune Polyglandular Syndromes
Nambam, B., Haller, M. J., Winter, W. E., & Schatz, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00022-1 · Cited by 8
Vieira, J. F., Murta, E., & Michelin, M. (2021) · Research, Society and Development · doi:10.33448/rsd-v10i13.20905
“That is an important point of DC vaccine: the ability to activate T lymphocytes and initiation of the specific immune response depends on the state of maturity, and also the maintenance of the long-term response (Lokhov & Balashova, 2010; Mathis & Benoist, 2004).”
BackgroundRole of regulatory T cells in immune tolerance
Swee, L. K. (2009) · edoc (University of Basel) · doi:10.5451/unibas-004811234
How Do T Cells Discriminate Self from Nonself?
Mazza, C., & MALISSEN, B. (2008) · Springer eBooks · doi:10.1007/978-4-431-73884-8_5
Molecular Basis for Induction of Tolerance in Type I Diabetes
Candon, S., Chatenoud, L., & Bach, J. (2007) · Springer eBooks · doi:10.1007/978-0-387-36003-4_6
Egr-2 and PD-1 Are Required for Induction and Maintenance of T Cell Anergy: A Dissertation
Bishop, K. (2005) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/jhfw-c454
Metadata
- Authors
- Mathis, D., & Benoist, C.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Benoist, Christophe
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 20
- Issue
- 5
- Pages
- 509-516
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2047784036
- Cited by
- 198
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 9 · 2013: 11 · 2012: 11
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3364 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- central tolerance, peripheral tolerance, immune tolerance, regulatory T cells, autoimmune disease, APECED, type 1 diabetes, autoimmunity
- MeSH terms
- AIRE Protein, Animals, Autoimmune Diseases, Cell Differentiation, Humans, Immune Tolerance, Lymphocyte Activation, T-Lymphocytes, Thymus Gland, Transcription Factors
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