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Cited by 101Aquaculture Nutrition and GrowthPhysiological and biochemical adaptationsMarine and fisheries research

Coronary arteriosclerosis in salmon: growing old or growing fast?

Farrell, A.P·2002·Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
DOI 10.1016/s1095-6433(02)00126-5
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Abstract

A review is presented of what we know and what we suspect regarding the formation of coronary arteriosclerotic lesions in salmonids. Coronary lesions are a fact of life for both Atlantic and Pacific species of migrating salmon. Severe forms of lesions, usually restricted to the main coronary artery, are typically found in the majority of a salmon population when they are spawning. Vascular injury to the coronary artery, as a result of the bulbus arteriosus being excessively distended, is proposed as an initiating mechanism for coronary lesion formation, possibly explaining why severe lesions are restricted primarily to the main coronary artery. Evidence is presented that coronary arteriosclerosis in salmonids develops in immature fish, well before maturation, and progresses with age. Growth and growth rate are implicated in lesion progression. A faster growth rate could produce a more stressful life style, which in turn initiates more coronary vascular injury. Dietary factors, especially polyunsaturated fatty acids (and their metabolites), can significantly stimulate vascular smooth muscle proliferation in the salmon coronary artery, but a possible linkage to the progression of coronary lesions has yet to be studied. Whether coronary lesions negatively impact blood flow to the salmon heart has not been properly studied. Nevertheless, the coronary blood supply to the heart has functional importance when salmon exercise and the coronary flow reserve may be reached when fish swim under mild hypoxic conditions. If coronary arterial lesions do adversely affect blood flow to the heart, the selective effects would be most prominent in years when upstream migration conditions are particularly severe.

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  • Allostatic overload can have a useful purpose for preservation of the species, such as in migrating salmon or the marsupial mouse, which die of excessive stress after mating.

    “However, allostatic overload can also have a useful purpose for the preservation of the species, such as In migrating salmon or the marsupial mouse, which die of excessive stress after mating- the stress, and allostatic load, being caused for salmon, In part, by the migration up the rapidly flowing rivers, but also because of physiological changes that represent accelerated aging.12-14”

    From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [12]

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Authors
Farrell, A. P.
Affiliations
Simon Fraser University (CA)
Corresponding author
Farrell, A.P
ORCID
Farrell, A.P
Venue
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
Publisher
Elsevier BV
Published
2002-08
Volume
132
Issue
4
Pages
723-735
ISSN
1095-6433 (ISSN-L)
DOI
10.1016/s1095-6433(02)00126-5
OpenAlex
W2110652520
Cited by
101
References
53
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 33 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 3
FWCI
2.17
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
  • Physical Sciences › Environmental Science › Global and Planetary Change › Marine and fisheries research
Keywords
coronary arteriosclerosis, salmonids, Atlantic salmon, Pacific salmon, coronary artery lesions, bulbus arteriosus, vascular injury, growth rate, polyunsaturated fatty acids, vascular smooth muscle cell proliferation, coronary blood flow, coronary flow reserve, hypoxia, fish migration, aging
MeSH terms
Animals, Coronary Artery Disease, Coronary Circulation, Coronary Vessels, Fish Diseases, Models, Cardiovascular, Salmon, Stress, Physiological

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