Glycogen resynthesis in the absence of food ingestion during recovery from moderate or high intensity physical activity: novel insights from rat and human studies
Abstract
The finding that during recovery from high intensity exercise, rats have the capacity to replenish their muscle glycogen stores even in the absence of food intake has provided us with an experimental model of choice to explore further this process. Our objective here is to share those questions arising from research carried out by others and ourselves on rats and humans that are likely to be of interest to comparative biochemists/physiologists. On the basis of our findings and those of others, it is proposed that across vertebrate species: (1). the capacity of muscles to replenish their glycogen stores from endogenous carbon sources is dependent on the type of physical activity and animal species; (2). lactate and amino acids are the major endogenous carbon sources mobilized for the resynthesis of muscle glycogen during recovery from exercise, their relative contributions depending on the duration of recovery and type of exercise; (3). the relative contributions of lactate glyconeogenesis and hepatic/renal gluconeogenesis to muscle glycogen synthesis is species- and muscle fiber-dependent; and (4). glycogen synthase and phosphorylase play an important role in the control of the rate of glycogen synthesis post-exercise, with the role of glucose transport being species-dependent.
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Lactate or glycerol is the primary carbon source for gluconeogenesis.
“and lactate or glycerol is the primary carbon source for gluconeogenesis [41].”
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- Authors
- Fournier, P. A., Bräu, L., Ferreira, L. D. M. C.-B., Fairchild, T., Raja, G., James, A., & Palmer, T. N.
- Affiliations
- The University of Western Australia (AU)
- James Cook University (AU)
- Corresponding author
- Fournier, P.A
- Venue
- Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 133
- Issue
- 3
- Pages
- 755-763
- ISSN
- 1095-6433 (ISSN-L)
- OpenAlex
- W1968477497
- Cited by
- 51
- References
- 49
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Murdoch University Research Portal (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Funders
- Australian Research Council
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- muscle glycogen resynthesis, post-exercise recovery, food deprivation, lactate, amino acids, gluconeogenesis, glycogen synthase, glycogen phosphorylase, glucose transport, muscle fiber type, species differences, high-intensity exercise, moderate-intensity exercise
- MeSH terms
- Animals, Eating, Physical Exertion, Fasting, Glycogen, Humans, Muscle, Skeletal, Rats
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