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Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer
Open accessAbstract
We have identified a human homolog of the Xenopus forkhead activin signal transducer-1 (xFAST-1). Although significantly different in sequence from its Xenopus counterpart, hFAST-1 shared with xFAST-1 the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE was completely dependent on endogenous Smad4 and stimulation by a TGF beta-like ligand. The hFAST-1 protein was shown to bind to a novel DNA motif, TGT (G/T) (T/G)ATT, an exact copy of which was present within the ARE. A single copy of this motif could activate a reporter in a TGF beta-dependent fashion but only when an adjacent Smad-binding element was present in the construct. These data suggest that responses to TGF beta family members may be mediated by a DNA-binding complex formed by hFAST-1, hSmad2, and hSmad4.
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Cites
Activation of Signalling by the Activin Receptor Complex
Attisano, L., Wrana, J. L., Montalvo, E., & Massagué, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1066 · Cited by 316
Cited by
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869
Stem cells: the intestinal stem cell as a paradigm
Bach, S. P., Renehan, A. G., & Potten, C. S. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.469 · Cited by 236
FoxH1(Fast) functions to specify the anterior primitive streak in the mouse
Hoodless, P. A., Pye, M., Chazaud, C., Labbé, E., Attisano, L., Rossant, J., & Wrana, J. L. (2001) · Genes & Development · doi:10.1101/gad.881501 · Cited by 203
Park, J.-I., Lee, M.-G., Cho, K., Park, B.-J., Chae, K.-S., Byun, D.-S., Ryu, B.-K., Park, Y.-K., & Chi, S.-G. (2003) · Oncogene · doi:10.1038/sj.onc.1206478 · Cited by 168
Trichostatin A blocks TGF-β-induced collagen gene expression in skin fibroblasts: Involvement of Sp1
Ghosh, A. K., Mori, Y., Dowling, E., & Varga, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.204 · Cited by 91
Metadata
- Authors
- Zhou, S., Zawel, L., Lengauer, C., Kinzler, K. W., & Vogelstein, B.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 2
- Issue
- 1
- Pages
- 121-127
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1989307537
- Cited by
- 230
- References
- 1
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhou, S., Zawel, L., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998). Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer. Molecular Cell. https://doi.org/10.1016/s1097-2765(00)80120-3
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