SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS

TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3

Liu, D., Black, B. L., & Derynck, R. (2001) · Genes & Development · doi:10.1101/gad.925901 · Cited by 399 · see citing works

Transforming Growth Factor-β Inhibits Adipocyte Differentiation by Smad3 Interacting with CCAAT/Enhancer-binding Protein (C/EBP) and Repressing C/EBP Transactivation Function

Choy, L., & Derynck, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212259200 · Cited by 343 · see citing works

Molecular mechanisms of epithelial–mesenchymal transition

Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091 · see citing works

TGF-β-induced epithelial to mesenchymal transition

Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804 · see citing works

Formation and function of the myofibroblast during tissue repair

Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658 · see citing works

TGF-β1 Signaling and Tissue Fibrosis

Kim, K. K., Sheppard, D., & Chapman, H. A. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022293 · Cited by 800 · see citing works

Specificity, versatility, and control of TGF-β family signaling

Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785 · see citing works

Protection from obesity and diabetes by blockade of TGF-β/smad3 signaling

Yadav, H., Quijano, C., Kamaraju, A. K., Gavrilova, O., Malek, R., Chen, W., Zerfas, P., Zhigang, D., Wright, E. C., Stuelten, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.013 · Cited by 709 · see citing works

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

Alarcón, C., Zaromytidou, A.-I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.035 · Cited by 719 · see citing works

Signaling Receptors for TGF-β Family Members

Heldin, C.-H., & Moustakas, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022053 · Cited by 711 · see citing works

A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response

Ding, N., Yu, R. T., Subramaniam, N., Sherman, M. H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.028 · Cited by 622 · see citing works

Transforming growth factor‐β in stem cells and tissue homeostasis

Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414 · see citing works

Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases

Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382 · see citing works

Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

Hu, L., Chen, W., Qian, A., & Li, Y.-P. (2024) · Bone Research · doi:10.1038/s41413-024-00342-8 · Cited by 359 · see citing works

TGF-β Signaling in Control of Cardiovascular Function

Goumans, M.-J., & ten Dijke, P. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022210 · Cited by 360 · see citing works

Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology

Tesseur, I., Zou, K., Esposito, L., Bard, F., Berber, E., Can, J. V., Lin, A. H., Crews, L., Tremblay, P., Mathews, P., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27341 · Cited by 355 · see citing works

BMP restricts stemness of intestinal Lgr5(+) stem cells by directly suppressing their signature genes

Qi, Z., Li, Y., Zhao, B., Xu, C., Liu, Y., Li, H., Zhang, B., Wang, X., Yang, X., Xie, W., et al. (2017) · Nature Communications · doi:10.1038/ncomms13824 · Cited by 320 · see citing works

Relative roles of TGF‐β1 and Wnt in the systemic regulation and aging of satellite cell responses

Carlson, M. E., Conboy, M. J., Hsu, M., Barchas, L., Jeong, J., Agrawal, A., Mikels, A. J., Agrawal, S., Schaffer, D. V., & Conboy, I. M. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00517.x · Cited by 244 · see citing works

The c‐myc Promoter: Still MysterY and Challenge

(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211 · see citing works

TGF-β family co-receptor function and signaling

Nickel, J., Ten Dijke, P., & Mueller, T. D. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx126 · Cited by 198 · see citing works

BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells

Ono, Y., Calhabeu, F., Morgan, J. E., Katagiri, T., Amthor, H., & Zammit, P. S. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.95 · Cited by 198 · see citing works

Skeletal muscle is an endocrine organ

Iizuka, K., Machida, T., & Hirafuji, M. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14r02cp · Cited by 189 · see citing works

The role of endothelial-mesenchymal transition in development and pathological process

Lin, F., Wang, N., & Zhang, T. (2012) · IUBMB Life · doi:10.1002/iub.1059 · Cited by 177 · see citing works

Transforming Growth Factor- <i>β</i> Activation in the Lung: Focus on Fibrosis and Reactive Oxygen Species

Koli, K., Myllärniemi, M., Keski-Oja, J., & Kinnula, V. L. (2008) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2007.1914 · Cited by 168 · see citing works

Essential Role of TGF-β Signaling in Glucose-Induced Cell Hypertrophy

Wu, L., & Derynck, R. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.05.010 · Cited by 167 · see citing works

TGFβ signalling plays an important role in IL4-induced alternative activation of microglia

Zhou, X., Spittau, B., & Krieglstein, K. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-210 · Cited by 159 · see citing works

The role of Smad signaling cascades in cardiac fibrosis

Hanna, A., Humeres, C., & Frangogiannis, N. G. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109826 · Cited by 132 · see citing works

Transforming growth factor β1 signaling coincides with epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis in mice

Shen, M., Liu, X., Zhang, H., & Guo, S.-W. (2015) · Human Reproduction · doi:10.1093/humrep/dev314 · Cited by 124 · see citing works

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice

Canali, S., Core, A. B., Zumbrennen-Bullough, K. B., Merkulova, M., Wang, C.-Y., Schneyer, A. L., Pietrangelo, A., & Babitt, J. L. (2016) · Endocrinology · doi:10.1210/en.2015-1747 · Cited by 113 · see citing works

Thyroid hormones inhibit TGF-β signaling and attenuate fibrotic responses

Alonso-Merino, E., Martín Orozco, R., Ruíz-Llorente, L., Martínez-Iglesias, O. A., Velasco-Martín, J. P., Montero-Pedrazuela, A., Fanjul-Rodríguez, L., Contreras-Jurado, C., Regadera, J., & Aranda, A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506113113 · Cited by 108 · see citing works

Transcriptome profiling of a TGF-β-induced epithelial-to-mesenchymal transition reveals extracellular clusterin as a target for therapeutic antibodies

Lenferink, A. E. G., Cantin, C., Nantel, A., Wang, E., Durocher, Y., Banville, M., Paul-Roc, B., Marcil, A., Wilson, M. R., & O'Connor-McCourt, M. D. (2010) · Oncogene · doi:10.1038/onc.2009.399 · Cited by 81 · see citing works

NOD-like receptors in intestinal homeostasis and epithelial tissue repair

Parlato, M., & Yeretssian, G. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069594 · Cited by 79 · see citing works

Co-ordination of cell cycle and differentiation in the developing nervous system

Hindley, C., & Philpott, A. (2012) · Biochemical Journal · doi:10.1042/bj20112040 · Cited by 76 · see citing works

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C. A., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H., & Zhang, A.-S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060534 · Cited by 69 · see citing works

TGF-β signaling is required for maintenance of retinal ganglion cell differentiation and survival

Walshe, T. E., Leach, L. L., & D'Amore, P. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.020 · Cited by 59 · see citing works

The effects of polydeoxyribonucleotide on wound healing and tissue regeneration: a systematic review of the literature

Colangelo, M. T., Galli, C., & Guizzardi, S. (2020) · Regenerative Medicine · doi:10.2217/rme-2019-0118 · Cited by 59 · see citing works

The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway

Li, J., Weinberg, M. S., Zerbini, L., & Prince, S. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-05-0273 · Cited by 56 · see citing works

<i>Ranbp1</i> , Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation

Paronett, E. M., Meechan, D. W., Karpinski, B. A., LaMantia, A.-S., & Maynard, T. M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu285 · Cited by 54 · see citing works

Substance P acting via the neurokinin-1 receptor regulates adverse myocardial remodeling in a rat model of hypertension

Dehlin, H. M., Manteufel, E. J., Monroe, A. L., Reimer, M. H., & Levick, S. P. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.07.190 · Cited by 55 · see citing works

The Anti-proliferative Function of the TGF-β1 Signaling Pathway Involves the Repression of the Oncogenic TBX2 by Its Homologue TBX3

Li, J., Ballim, D., Rodriguez, M., Cui, R., Goding, C. R., Teng, H., & Prince, S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.596411 · Cited by 44 · see citing works

Temporal Smad7 Transgene Induction in Mouse Epidermis Accelerates Skin Wound Healing

Han, G., Li, F., ten Dijke, P., & Wang, X.-J. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.003 · Cited by 39 · see citing works

SARA is dispensable for functional TGF‐β signaling

Bakkebø, M., Huse, K., Hilden, V. I., Forfang, L., Myklebust, J. H., Smeland, E. B., & Oksvold, M. P. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.07.027 · Cited by 30 · see citing works