Control of β-Catenin Stability

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Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

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XIdax, an inhibitor of the canonical Wnt pathway, is required for anterior neural structure formation in Xenopus

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Targeted perturbation of signaling-driven condensates

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Igf3 activates β-catenin signaling to stimulate spermatogonial differentiation in zebrafish

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The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation

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Re-Evaluating the Role of Frat in Wnt-Signal Transduction

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The Canonical Wnt Pathway Regulates Retinal Stem Cells/Progenitors in Concert with Notch Signaling

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Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells

Lee, M.-A., Kim, W. K., Park, H. J., Kang, S. S., & Lee, S. K. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.08.065 · Cited by 33

Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast

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The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitro

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PAI-1 modulates cell migration in a LRP1-dependent manner via β-catenin and ERK1/2

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Human Cytomegalovirus Inhibits the PARsylation Activity of Tankyrase—A Potential Strategy for Suppression of the Wnt Pathway

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Clinical Significance of Inactivated Glycogen Synthase Kinase 3β in HPV ‐Associated Cervical Cancer: Relationship with W nt/β‐ C atenin Pathway Activation

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APC and β-Catenin Degradation

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Casein Kinase 1α as a Regulator of Wnt-Driven Cancer

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Toggling a Conformational Switch in Wnt/β-catenin Signaling: Regulation of Axin Phosphorylation

Tacchelly-Benites, O., Wang, Z.-H., Yang, E., Lee, E., & Ahmed, Y. (2013) · Bioessays · doi:10.1002/bies.201300101 · Cited by 32

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC

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Discovery of Novel Inhibitor for WNT/β-Catenin Pathway by Tankyrase 1/2 Structure-Based Virtual Screening

Li, B., Liang, J., Lu, F., Zeng, G., Zhang, J., Ma, Y., Liu, P., Wang, Q., Zhou, Q., & Chen, L. (2020) · Molecules · doi:10.3390/molecules25071680 · Cited by 30

Reconstituting regulation of the canonical Wnt pathway by engineering a minimal β-catenin destruction machine

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Generation of Axin1 conditional mutant mice

Xie, R., Jiang, R., & Chen, D. (2010) · genesis · doi:10.1002/dvg.20703 · Cited by 28

Molecular control of the oocyte to embryo transition

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Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase

Wang, Z., Tacchelly‐Benites, O., Yang, E., Thorne, C. A., Nojima, H., Lee, E. N., & Ahmed, Y. F. (2016) · Genetics · doi:10.1534/genetics.115.183244 · Cited by 27

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin

Aznar, N., Sun, N. N., Dunkel, Y., Ear, J., Buschman, M. D., & Ghosh, P. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-06-0405 · Cited by 27

Dpr Acts as a Molecular Switch, Inhibiting Wnt Signaling when Unphosphorylated, but Promoting Wnt Signaling when Phosphorylated by Casein Kinase Iδ/ε

Teran, E., Branscomb, A. D., & Seeling, J. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005522 · Cited by 27

Migfilin Regulates Esophageal Cancer Cell Motility through Promoting GSK-3β–Mediated Degradation of β-Catenin

He, H., Ding, F., Li, Y., Luo, A., Chen, H., Wu, C., & Liu, Z. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0419 · Cited by 28

Molecular docking studies of flavonoids for their inhibition pattern against β-catenin and pharmacophore model generation from experimentally known flavonoids to fabricate more potent inhibitors for Wnt signaling pathway

Rashid, S., & Iftikhar, H. (2014) · Pharmacognosy Magazine · doi:10.4103/0973-1296.133269 · Cited by 26

Knockdown of FRAT1 Expression by RNA Interference Inhibits Human Glioblastoma Cell Growth, Migration and Invasion

Guo, G., Kuai, D., Cai, S., Xue, N., Liu, Y., Hao, J.-H., Fan, Y., Ji, J., Mao, X., Liu, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061206 · Cited by 26

Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migration

Zhu, Z. X., Sun, C., Zhu, Y. T., Wang, Y., Wang, T., Sha, L., Cai, W. H., Zheng, J. Y., Zhou, X., Cong, W. T., et al. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.054 · Cited by 27

Fsh stimulates Leydig cell Wnt5a production, enriching zebrafish type A spermatogonia

Safian, D., Ryane, N., Bogerd, J., & Schulz, R. W. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0447 · Cited by 25

Signalling through the Type 1 Insulin-Like Growth Factor Receptor (IGF1R) Interacts with Canonical Wnt Signalling to Promote Neural Proliferation in Developing Brain

Hu, Q., Lee, S. Y., OʼKusky, J. R., & Ye, P. (2012) · ASN NEURO · doi:10.1042/an20120009 · Cited by 23

Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation

Li, T., Ren, J., Husmann, D., Coan, J. P., Gozani, O., & Chua, K. F. (2020) · Scientific Reports · doi:10.1038/s41598-020-74080-2 · Cited by 23

The expression profile of FRAT1 in human gliomas

Guo, G., Mao, X., Wang, P., Liu, B., Zhang, X., Jiang, X., Zhong, C., Huo, J., Ji, J., & Zhuo, Y. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.037 · Cited by 23

Interactions between β-Catenin and the HSlo Potassium Channel Regulates HSlo Surface Expression

Bian, S., Bai, J.-P., Chapin, H. C., Moëllic, C. L., Dong, H., Caplan, M. J., Sigworth, F. J., & Navaratnam, D. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028264 · Cited by 23

ROCK2 regulates bFGF-induced proliferation of SH-SY5Y cells through GSK-3β and β-catenin pathway

Boku, S., Nakagawa, S., Toda, H., Kato, A., Takamura, N., Omiya, Y., Inoue, T., & Koyama, T. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.034 · Cited by 23

FRAT1 expression and its correlation with pathologic grade, proliferation, and apoptosis in human astrocytomas

Guo, G., Liu, B., Zhong, C., Zhang, X., Mao, X., Wang, P., Jiang, X., Huo, J., Ji, J., Liu, X., et al. (2009) · Medical Oncology · doi:10.1007/s12032-009-9402-x · Cited by 22

Multiscale Models of Cell Signaling

Bajikar, S. S., & Janes, K. A. (2012) · Annals of Biomedical Engineering · doi:10.1007/s10439-012-0560-1 · Cited by 22

Overexpression of Frat1 correlates with malignant phenotype and advanced stage in human non-small cell lung cancer

Zhang, Y., Yu, J., Lin, X., Miao, Y., Han, Y., Fan, C., Dong, X.-J., Dai, S., & Wang, E. (2011) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-011-1135-5 · Cited by 22

Points of Therapeutic Intervention Along the Wnt Signaling Pathway in Hepatocellular Carcinoma

Nambotin, S. B., Wands, J. R., & Kim, M. (2011) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152011796011019 · Cited by 22

Relating simulation studies by provenance—Developing a family of Wnt signaling models

Budde, K., Smith, J., Wilsdorf, P., Haack, F., & Uhrmacher, A. M. (2021) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1009227 · Cited by 23

Gonadotropin-Releasing Hormone-II Increases Membrane Type I Metalloproteinase Production via β-Catenin Signaling in Ovarian Cancer Cells

Poon, S. L., Lau, M.-T., Hammond, G. L., & Leung, P. C. K. (2011) · Endocrinology · doi:10.1210/en.2010-0942 · Cited by 21

The Integrated Role of Wnt/β-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics

Vargas, D. A., Sun, M., Sadykov, K., Kukuruzinska, M. A., & Zaman, M. H. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005007 · Cited by 22

Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling

Wang, Z., Tacchelly‐Benites, O., Yang, E., & Ahmed, Y. F. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006494 · Cited by 20

Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen

Benchabane, H., Hughes, E. G., Takacs, C. M., Baird, J. R., & Ahmed, Y. F. (2008) · Development · doi:10.1242/dev.013805 · Cited by 21

Controlling Hair Follicle Signaling Pathways through Polyubiquitination

Huntzicker, E. G., & Oro, A. E. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700957 · Cited by 19

N-Terminal Domain Mediated Regulation of RORα1 Inhibits Invasive Growth in Prostate Cancer

Park, S. C., Park, I.-G., Kim, H.-K., & Lee, J. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071684 · Cited by 19

Involvement of the residues of GSKIP, AxinGID, and FRATtide in their binding with GSK3β to unravel a novel C-terminal scaffold-binding region

Howng, S., Hwang, C., Hsu, C., Hsu, M.-Y., Teng, C.-Y., Chou, C., Lee, M.-F., Wu, C.-H., Chiou, S.-J., Lieu, A., et al. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0366-0 · Cited by 19

The structural and functional determinants of the Axin and Dishevelled DIX domains

Ehebauer, M. T., & Arias, A. M. (2009) · BMC Structural Biology · doi:10.1186/1472-6807-9-70 · Cited by 19

Targeting GPCRs and Their Signaling as a Therapeutic Option in Melanoma

Raymond, J. H., Aktary, Z., Larue, L., & Delmas, V. (2022) · Cancers · doi:10.3390/cancers14030706 · Cited by 20

Feedback in the β-catenin destruction complex imparts bistability and cellular memory

Cantoria, M. J., Alizadeh, E., Ravi, J., Varghese, R. P., Bunnag, N., Pond, K. W., Kettenbach, A. N., Ahmed, Y. F., Paek, A. L., Tyson, J. J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208787120 · Cited by 18

Hypoxia induced δ-Catenin to enhance mice hepatocellular carcinoma progression via Wnt signaling

Huang, F., Chen, J., Lan, R., Wang, Z., Chen, R., Lin, J., & Fu, L. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.11.011 · Cited by 18

Intranasal wnt-3a alleviates neuronal apoptosis in early brain injury post subarachnoid hemorrhage via the regulation of wnt target PPAN mediated by the moonlighting role of aldolase C

Ruan, W., Hu, J., Zhou, H., Yin, L., Xu, C., Luo, Y., Chen, T., Xu, B., Yan, F., & Chen, G. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104656 · Cited by 18

FRAT1, a Substrate-specific Regulator of Glycogen Synthase Kinase-3 Activity, Is a Cellular Substrate of Protein Kinase A

Hagen, T., Cross, D. A. E., Culbert, A. A., West, A., Frame, S., MORRICE, N. A., & Reith, A. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607003200 · Cited by 17

Histone Acetylation-Mediated Regulation of the Hippo Pathway

Basu, D., Reyes‐Múgica, M., & Rebbaa, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062478 · Cited by 20

Wingless Signaling: An Axin to Grind

Jones, W. M., & Bejsovec, A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00407-x · Cited by 18

AXIN2 germline testing in a French cohort validates pathogenic variants as a rare cause of predisposition to colorectal polyposis and cancer

Leclerc, J., Beaumont, M., Vibert, R., Pinson, S., Vermaut, C., Flament, C., Lovecchio, T., Delattre, L., Demay, C., Coulet, F., et al. (2022) · Genes Chromosomes and Cancer · doi:10.1002/gcc.23112 · Cited by 18

A Biochemical Screen for Identification of Small-Molecule Regulators of the Wnt Pathway Using Xenopus Egg Extracts

Thorne, C. A., LaFleur, B., Lewis, M., Hanson, A. J., Jernigan, K. K., Weaver, D. C., Huppert, K. A., Chen, T. W., Wichaidit, C., Cselenyi, C. S., et al. (2011) · SLAS DISCOVERY · doi:10.1177/1087057111416657 · Cited by 18

Uncomplicated human obesity is associated with a specific cardiac transcriptome: involvement of the Wnt pathway

Philip‐Couderc, P., Pathak, A., Smih, F., Dambrin, C., Harmancey, R., Buys, S., Galinier, M., MASSABUAU, P., Roncalli, J. G., Sénard, J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.03-1242fje · Cited by 17

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

Koirala, S., Klein, J. D., Zheng, Y., Glenn, N. O., Eisemann, T., Tacer, K. F., Miller, D. J., Kulak, O., Lu, M., Finkelstein, D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107922 · Cited by 17

Involvement of VAT ‐1 in Phosphatidylserine Transfer from the Endoplasmic Reticulum to Mitochondria

Junker, M., & Rapoport, T. A. (2015) · Traffic · doi:10.1111/tra.12336 · Cited by 16

Exosomal microRNA concentrations in colorectal cancer: A mathematical model

Lai, X., & Friedman, A. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2016.12.006 · Cited by 18

Aberrant Chondrocyte Hypertrophy and Activation of ß-Catenin Signaling Precede Joint Ankylosis inank/ankMice

Heras, F. L., Pritzker, K. P. H., So, A. K.-C., Tsui, H. W., Chiu, B., Inman, R. D., & Tsui, F. W. L. (2012) · The Journal of Rheumatology · doi:10.3899/jrheum.110971 · Cited by 15

Neural Differentiation Is Inhibited through HIF1α/β-Catenin Signaling in Embryoid Bodies

Večeřa, J., Kudová, J., Kučera, J., Kubala, L., & Pachernı́k, J. (2017) · Stem Cells International · doi:10.1155/2017/8715798 · Cited by 15

Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis

Demidov, O. N., Zhu, Y., Kek, C., Goloudina, A. R., Motoyama, N., & Bulavin, D. V. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.57 · Cited by 14

Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin

Gillis, W. J., Kirmizitas, A., Iwasaki, Y., Ki, D. H., Wyrick, J. M., & Thomsen, G. H. (2016) · Cell Communication and Signaling · doi:10.1186/s12964-016-0138-x · Cited by 14

Crystallization and preliminary X-ray crystallographic studies of the axin DIX domain

Shibata, N., Tomimoto, Y., Hanamura, T., Yamamoto, R., Ueda, M., Ueda, Y., Mizuno, N., Ogata, H., Komori, H., Shomura, Y., et al. (2007) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309107022579 · Cited by 14

Glycogen content relative to expression of glycogen phosphorylase (GPH) and hexokinase (HK) during the reproductive cycle in the Fujian Oyster, Crassostrea angulata

Zeng, Z., Ni, J., & Ke, C. (2015) · Acta Oceanologica Sinica · doi:10.1007/s13131-015-0639-2 · Cited by 13

Ubiquitin-mediated proteolysis in Xenopus extract

McDowell, G. S., & Philpott, A. (2016) · The International Journal of Developmental Biology · doi:10.1387/ijdb.160186gm · Cited by 13

Valproate recovers the inhibitory effect of dexamethasone on the proliferation of the adult dentate gyrus-derived neural precursor cells via GSK-3β and β-catenin pathway

Boku, S., Nakagawa, S., Masuda, T., Nishikawa, H., Kato, A., Takamura, N., Omiya, Y., Kitaichi, Y., Inoue, T., & Kusumi, I. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.060 · Cited by 13

Structural basis for Ccd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain

Terawaki, S., Fujita, S., Katsutani, T., Shiomi, K., Keino‐Masu, K., Masu, M., Wakamatsu, K., Shibata, N., & Higuchi, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-08019-5 · Cited by 12

The Power of Xenopus Egg Extract for Reconstitution of Centromere and Kinetochore Function

French, B. T., & Straight, A. F. (2017) · Progress in molecular and subcellular biology · doi:10.1007/978-3-319-58592-5_3 · Cited by 11

Phosphorylation and Proteolytic Cleavage of Notch in Canonical and Noncanonical Notch Signaling

Hunter, G. L., & Giniger, E. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-36422-9_4 · Cited by 10

Identifying Small Molecule Inhibitors of the Ubiquitin‐Proteasome Pathway in Xenopus Egg Extracts

Salic, A. N., & King, R. W. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)99038-1 · Cited by 10

Studying Wnt Signaling in Xenopus

Hoppler, S. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-469-2_21 · Cited by 9

Reorganization of actin cytoskeleton by FRIED, a Frizzled‐8 associated protein tyrosine phosphatase

Itoh, K., Lisovsky, M., Hikasa, H., & Sokol, S. Y. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20526 · Cited by 8

Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs

Hang, B. I., Thorne, C. A., Robbins, D. J., Huppert, S. S., Lee, L. A., & Lee, E. N. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.12.044 · Cited by 8

Modulation of β-catenin by cyclin-dependent kinase 6 in Wnt-stimulated cells

Park, C. S., Lee, M. S., Oh, H., Choi, K. Y., Yeo, M. G., Chun, J., & Song, W. K. (2007) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.10.004 · Cited by 7

Xom induces proteolysis of β‐catenin through GSK 3β‐mediated pathway

Wu, B., Gao, H., Le, Y., Wu, X., & Zhu, Z. (2017) · FEBS Letters · doi:10.1002/1873-3468.12949 · Cited by 7

The Wnt/ -catenin Pathway

Moon, R. T. (2003) · Science Signaling · doi:10.1126/stke.2003.194.cm3 · Cited by 8

Targeting β-catenin: PROTACs and precision degraders for Wnt-driven cancers

Trapani, J. B., Caroland, K. P., Ahmed, Y. F., Robbins, D. J., Weiss, V. L., & Lee, E. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1777843 · Cited by 6

Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors

Deacon, S., & Peterson, J. R. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72843-6_18 · Cited by 6

The RNF146 E3 ubiquitin ligase is required for the control of Wnt signaling and body pattern formation in Xenopus

Zhu, X., Xing, R., Tan, R., Dai, R., & Tao, Q. (2017) · Mechanisms of Development · doi:10.1016/j.mod.2017.08.001 · Cited by 6

A novel GTPBP2 splicing mutation in two siblings affected with microcephaly, generalized muscular atrophy, and hypotrichosis

Rad, I. A., Vahabi, A., & Akbariazar, E. (2020) · Clinical Case Reports · doi:10.1002/ccr3.3637 · Cited by 6

Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila

Gültekin, Y., & Steller, H. (2019) · Development · doi:10.1242/dev.169284 · Cited by 6

β-Catenin: A Metazoan Filter for Biological Noise?

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Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy

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Intracellular signal propagation in a two-dimensional autocatalytic reaction model

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Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity

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Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis

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Redox-Mediated Rewiring of Signalling Pathways: The Role of a Cellular Clock in Brain Health and Disease

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Role of Phytochemicals in Modulating Signaling Cascades in Cancer Cells

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Small-Molecule High-Throughput Screening Utilizing Xenopus Egg Extract

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Reconstitution of the Cytoplasmic Regulation of the Wnt Signaling Pathway Using Xenopus Egg Extracts

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A Promising Drug Candidate as Potent Therapeutic Approach for Neuroinflammation and Its In Silico Justification of Chalcone Congeners: a Comprehensive Review

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Reconstitution Of β-catenin Degradation In Xenopus Egg Extract

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Unravelling the Mechanistic Role of Quinazolinone Pharmacophore in the Inhibitory Activity of Bis-quinazolinone Derivative on Tankyrase-1 in the Treatment of Colorectal Cancer (CRC) and Non-small Cell Lung Cancer (NSCLC): A Computational Approach

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Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein

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The B56α subunit of PP2A is necessary for mesenchymal stem cell commitment to adipocyte

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Crystallographic characterization of the DIX domain of the Wnt signalling positive regulator Ccd1

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Wnt Signaling Drives Ectopic Gene Expression and Larval Arrest in the Absence of theCaenorhabditis elegansDREAM Repressor Complex

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Tankyrase Inhibitor for Cardiac Tissue Regeneration: an In-silico Approach.

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

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Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complexPreprint

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Physiological regulation of β-catenin stability by Tcf3 and CK1ϵ

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Axin prevents Wnt-3a-induced accumulation of β-catenin

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Rapid, Wnt-Induced Changes in GSK3β Associations that Regulate β-Catenin Stabilization Are Mediated by Gα Proteins

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Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability

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