Kirschner, Marc W.

Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells

Klein, A. M., Mazutis, L., Akartuna, I., Tallapragada, N., Veres, A., Li, V., Peshkin, L., Weitz, D. A., & Kirschner, M. W. (2015) · Cell

Single-cell and spatial transcriptomicsInnovative Microfluidic and Catalytic Techniques Innovation

Cited by 3,356

Dynamic instability of microtubule growth

Mitchison, T., & Kirschner, M. (1984) · Nature

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 3,337

A protein factor essential for microtubule assembly

Weingarten, M. D., Lockwood, A. H., Hwo, S. Y., & Kirschner, M. W. (1975) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsAlzheimer's disease research and treatments

Cited by 3,089

Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS

Gerber, S. A., Rush, J., Stemman, O., Kirschner, M. W., & Gygi, S. P. (2003) · Proceedings of the National Academy of Sciences

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 1,733

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 1,403

How Proteolysis Drives the Cell Cycle

King, R. W., Deshaies, R. J., Peters, J.-M., & Kirschner, M. W. (1996) · Science

Ubiquitin and proteasome pathwaysMicrotubule and mitosis dynamics

Cited by 1,273

Evolvability

Kirschner, M., & Gerhart, J. (1998) · Proceedings of the National Academy of Sciences

Evolution and Genetic DynamicsDevelopmental Biology and Gene Regulation

Cited by 1,129

A major developmental transition in early xenopus embryos: II. control of the onset of transcription

Newport, J., & Kirschner, M. (1982) · Cell

Developmental Biology and Gene RegulationGenomics and Chromatin Dynamics

Cited by 1,055

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

Cleveland, D. W., Hwo, S.-Y., & Kirschner, M. W. (1977) · Journal of Molecular Biology

Microtubule and mitosis dynamicsAlzheimer's disease research and treatments

Cited by 915

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002) · Nature

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 835

Rescuing US biomedical research from its systemic flaws

Alberts, B., Kirschner, M. W., Tilghman, S., & Varmus, H. (2014) · Proceedings of the National Academy of Sciences

Health and Medical Research ImpactsResearch, Science, and Academia

Cited by 817

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

Lee, E., Salic, A., Krüger, R., Heinrich, R., & Kirschner, M. W. (2003) · PLoS Biology

Wnt/β-catenin signaling in development and cancerGene Regulatory Network Analysis

Cited by 708

Tau protein binds to microtubules through a flexible array of distributed weak sites.

Butner, K. A., & Kirschner, M. W. (1991) · The Journal of cell biology

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 550

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

Chen, J., Jackson, P. K., Kirschner, M. W., & Dutta, A. (1995) · Nature

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 548

Anteroposterior patterning in hemichordates and the origins of the chordate nervous system

Lowe, C. J., Wu, M., Salic, A., Evans, L., Lander, E., Stange-Thomann, N., Gruber, C. E., Gerhart, J., & Kirschner, M. (2003) · Cell

Developmental Biology and Gene RegulationMarine Invertebrate Physiology and Ecology

Cited by 531

The Incoherent Feedforward Loop Can Provide Fold-Change Detection in Gene Regulation

Goentoro, L., Shoval, O., Kirschner, M. W., & Alon, U. (2009) · Molecular Cell

Gene Regulatory Network AnalysisBacterial Genetics and Biotechnology

Cited by 424

Using buoyant mass to measure the growth of single cells

Godin, M., Delgado, F. F., Son, S., Grover, W. H., Bryan, A. K., Tzur, A., Jorgensen, P., Payer, K., Grossman, A. D., Kirschner, M. W., et al. (2010) · Nature Methods

Microfluidic and Bio-sensing TechnologiesAcoustic Wave Resonator Technologies

Cited by 394

Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution

Lowe, C. J., Terasaki, M., Wu, M., Freeman, R. M., Runft, L., Kwan, K., Haigo, S., Aronowicz, J., Lander, E., Gruber, C., et al. (2006) · PLoS Biology

Developmental Biology and Gene RegulationMarine Invertebrate Physiology and Ecology

Cited by 385

Control of β-Catenin Stability

Salic, A., Lee, E., Mayer, L., & Kirschner, M. W. (2000) · Molecular Cell

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 335

Microtubule dynamics in interphase cells

Schulze, E., & Kirschner, M. (1986) · The Journal of cell biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 335

Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

Goentoro, L., & Kirschner, M. W. (2009) · Molecular Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 300

Activation of the WAVE Complex by Coincident Signals Controls Actin Assembly

Lebensohn, A. M., & Kirschner, M. W. (2009) · Molecular Cell

Cellular Mechanics and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 263

Tubulin requires tau for growth onto microtubule initiating sites.

Witman, G. B., Cleveland, D. W., Weingarten, M. D., & Kirschner, M. W. (1976) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsAlzheimer's disease research and treatments

Cited by 238

Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle

Kafri, R., Levy, J., Ginzberg, M. B., Oh, S., Lahav, G., & Kirschner, M. W. (2013) · Nature

Gene Regulatory Network AnalysisMicrotubule and mitosis dynamics

Cited by 232