The high-pathogenicity island: an iron-uptake island
Open accessAbstract
Highly pathogenic Yersinia carry a pathogenicity island termed high-pathogenicity island (HPI). The Yersinia HPI comprises genes involved in the synthesis of the siderophore yersiniabactin and can thus be regarded as an iron-uptake island. A unique characteristic of the HPI is its wide distribution among different enterobacteria such as Escherichia coli, Klebsiella, Citrobacter and Salmonella. Other types of iron-uptake systems are also carried by different pathogenicity islands in enterobacteria.
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The lack of effect of hepcidin or systemic iron loading on Yersinia O8 and S aureus may be because the O8 strain can scavenge iron from multiple sources and is less sensitive to iron availability because it grows slower than O9, and S aureus primarily uses heme iron during infection initiation.
“This may be because the O8 strain can scavenge iron from multiple sources and is less sensitive to iron availability because it grows slower than 09,14,16 and S aureus was shown to primarily use heme iron during infection initiation.23”
From Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron (2017) · cites this paper as [14]
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- Authors
- Carniel, E.
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 3
- Issue
- 7
- Pages
- 561-569
- ISSN
- 1286-4579 (ISSN-L)
- OpenAlex
- W1988835900
- Cited by
- 253
- References
- 2
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 15 · 2023: 12 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 10 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 12 · 2014: 19 · 2013: 5 · 2012: 9
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Yersinia bacterium, plague, ectoparasites research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- high-pathogenicity island, Yersinia, pathogenicity islands, iron absorption, siderophores, yersiniabactin, siderophore biosynthesis, Enterobacteriaceae, Escherichia coli, Klebsiella, Citrobacter, Salmonella, virulence genes
- MeSH terms
- Animals, Bacterial Outer Membrane Proteins, Bacterial Proteins, Enterobacteriaceae, Genes, Bacterial, Humans, Iron, Phenols, Thiazoles, Virulence, Yersinia, Yersinia Infections, Siderophores, Evolution, Molecular, Iron-Binding Proteins, Periplasmic Binding Proteins
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