Hunger for iron: the alternative siderophore iron scavenging systems in highly virulent Yersinia
Open accessAbstract
Low molecular weight siderophores are used by many living organisms to scavenge scarcely available ferric iron. Presence of at least a single siderophore-based iron acquisition system is usually acknowledged as a virulence-associated trait and a pre-requisite to become an efficient and successful pathogen. Currently, it is assumed that yersiniabactin (Ybt) is the solely functional endogenous siderophore iron uptake system in highly virulent Yersinia (Yersinia pestis, Y. pseudotuberculosis, and Y. enterocolitica biotype 1B). Genes responsible for biosynthesis, transport, and regulation of the yersiniabactin (ybt) production are clustered on a mobile genetic element, the High-Pathogenicity Island (HPI) that is responsible for broad dissemination of the ybt genes in Enterobacteriaceae. However, the ybt gene cluster is absent from nearly half of Y. pseudotuberculosis O3 isolates and epidemic Y. pseudotuberculosis O1 isolates responsible for the Far East Scarlet-like Fever. Several potential siderophore-mediated iron uptake gene clusters are documented in Yersinia genomes, however, neither of them have been proven to be functional. It has been suggested that at least two siderophores alternative to Ybt may operate in the highly virulent Yersinia pestis/Y. pseudotuberculosis group, and are referred to as pseudochelin (Pch) and yersiniachelin (Ych). Furthermore, most sporadic Y. pseudotuberculosis O1 strains possess gene clusters encoding all three iron scavenging systems. Thus, the Ybt system appears not to be the sole endogenous siderophore iron uptake system in the highly virulent yersiniae and may be efficiently substituted and/or supplemented by alternative iron siderophore scavenging systems.
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Yersinia enterocolitica and Y. pseudotuberculosis encode uptake receptors for yersiniabactin and other siderophores to support their iron needs.
“Yersinia enterocolitica and Y. pseudotuberculosis encode uptake receptors for yersiniabactin and other siderophores to support their iron needs (Rakin et al., 2012).”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Rakin et al., 2012
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- Authors
- Rakin, A., Schneider, L., & Podladchikova, O.
- Affiliations
- Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie (DE)
- Corresponding author
- Rakin, Alexander
- ORCID
- Rakin, Alexander
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 2
- Pages
- 151-151
- ISSN
- 2235-2988 (ISSN-L)
- PMC
- PMC3510459
- OpenAlex
- W1987799039
- Cited by
- 89
- References
- 59
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 9 · 2014: 4 · 2013: 6
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Yersinia bacterium, plague, ectoparasites research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- siderophore-mediated iron acquisition, Yersinia, yersiniabactin, high-pathogenicity island, Yersinia pestis, Yersinia pseudotuberculosis, Yersinia enterocolitica, virulence, iron scavenging, mobile genetic elements, gene clusters
- MeSH terms
- Multigene Family, Humans, Iron, Phenols, Thiazoles, Yersinia enterocolitica, Yersinia pestis, Yersinia pseudotuberculosis, Siderophores, Interspersed Repetitive Sequences, Virulence Factors, Genomic Islands, Biosynthetic Pathways
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