Cited by 220HIV Research and TreatmentHIV/AIDS Research and InterventionsReproductive tract infections research

Target cells in vaginal HIV transmission

Open access
Miller, Christopher J., Shattock, Robin J.·2003·Microbes and Infection

Abstract

Understanding the mechanisms of HIV transmission to women will be crucial to the development of effective strategies to curb this epidemic. Current data suggest that HIV has at least two routes to penetrate the vaginal epithelium and reach lymphoid tissues, trans-epithelial migration of infected Langerhans cells or virus penetration into the lamina propria through loss of epithelial integrity resulting in direct infection of lymphocytes, dendritic cells and macrophages.

Integrity signals

Registry

Crossref · 10.1016/s1286-4579(02)00056-4

Cites

83 of 83 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • APCs, such as DCs and macrophages, are the first targets of HIV-1 and HTLV-1 during transmission via sexual routes and breastfeeding.

    “APCs, such as DCs and macrophages, are the first targets of HIV-1 and HTLV-1 during transmission via sexual routes and breastfeeding [56,57,58,59].”

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3 of the 86 references couldn’t be matched to a known paper.

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Authors
Miller, C. J., & Shattock, R. J.
Affiliations
  • University of California, Davis (US)
  • St George's, University of London (GB)
Corresponding author
Miller, Christopher J.
Venue
Microbes and Infection
Publisher
Elsevier BV
Published
2003-01
Volume
5
Issue
1
Pages
59-67
ISSN
1286-4579 (ISSN-L)
OpenAlex
W2028603136
Cited by
220
References
86
Citations by year
2024: 1 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 22 · 2013: 9 · 2012: 13
FWCI
2.22
Type
journal article
Language
en
Open access
Locations
  • Microbes and Infection (publishedVersion)
  • PubMed (publishedVersion)
Funders
Rockefeller Foundation
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
HIV transmission, target cells, vaginal epithelium, Langerhans cells, lamina propria, lymphoid tissue, dendritic cells, macrophages, epithelial barrier integrity, women
MeSH terms
Animals, Epithelium, Female, HIV, Humans, Immunologic Factors, Macaca, Vagina, Simian Immunodeficiency Virus, HIV Infections, Simian Acquired Immunodeficiency Syndrome

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