Cited by 220HIV Research and TreatmentHIV/AIDS Research and InterventionsReproductive tract infections research

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Target cells in vaginal HIV transmission

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Miller, Christopher J., Shattock, Robin J.·2003·Microbes and Infection

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Abstract

Understanding the mechanisms of HIV transmission to women will be crucial to the development of effective strategies to curb this epidemic. Current data suggest that HIV has at least two routes to penetrate the vaginal epithelium and reach lymphoid tissues, trans-epithelial migration of infected Langerhans cells or virus penetration into the lamina propria through loss of epithelial integrity resulting in direct infection of lymphocytes, dendritic cells and macrophages.

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Crossref · 10.1016/s1286-4579(02)00056-4

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Authors: Miller, C. J., & Shattock, R. J.
Affiliations: University of California, Davis (US)
St George's, University of London (GB)
Corresponding author: Miller, Christopher J.
ORCID: Miller, Christopher J.
Shattock, Robin J.
Venue: Microbes and Infection
Publisher: Elsevier BV
Published: 2003-01
Volume: 5
Issue: 1
Pages: 59-67
ISSN: 1286-4579 (ISSN-L)
DOI: 10.1016/s1286-4579(02)00056-4
OpenAlex: W2028603136
Cited by: 220
References: 86
Citations by year: 2024: 1 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 22 · 2013: 9 · 2012: 13
FWCI: 2.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7636 d)
Locations: Microbes and Infection (publishedVersion)
PubMed (publishedVersion)
Funders: Rockefeller Foundation
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords: HIV transmission, target cells, vaginal epithelium, Langerhans cells, lamina propria, lymphoid tissue, dendritic cells, macrophages, epithelial barrier integrity, women
MeSH terms: Animals, Epithelium, Female, HIV, Humans, Immunologic Factors, Macaca, Vagina, Simian Immunodeficiency Virus, HIV Infections, Simian Acquired Immunodeficiency Syndrome

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