The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Neuronal death in glaucoma
Open accessAbstract
Glaucoma is recognized to have its major detrimental effect upon the eye by killing retinal ganglion cells. The process of cell death appears to be initiated at the optic nerve head, though other sites of injury are possible but unsubstantiated. At present the injury at the nerve head seems related to the level of the eye pressure, but its detailed mechanism is as yet unexplained. There is a greater loss of ganglion cells from some areas of the eye, and this feature of glaucoma seems related to the regional structure of the supporting connective tissues of the optic nerve head. Larger retinal ganglion cells have been consistently shown to have somewhat greater susceptibility to injury in glaucoma, though all cells are injured, even early in the process. Ganglion cells die by apoptosis in human and experimental glaucoma, opening several potential areas for future therapies to protect them from dying. Neurotrophin deprivation is one possible cause of cell death and replacement therapy is a potential approach to treatment.
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Cites
Racial Differences in the Cause-Specific Prevalence of Blindness in East Baltimore
Sommer, A., Tielsch, J. M., Katz, J., Quigley, H. A., Gottsch, J. D., Javitt, J. C., Martone, J. F., Royall, R. M., Witt, K. A., & Ezrine, S. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111143252004 · Cited by 764
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Cited by
Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration
LIBBY, R. T., ANDERSON, M. G., PANG, I.-H., ROBINSON, Z. H., SAVINOVA, O. V., COSMA, I. M., SNOW, A., WILSON, L. A., SMITH, R. S., CLARK, A. F., et al. (2005) · Visual Neuroscience · doi:10.1017/s0952523805225130 · Cited by 409
Distal axonopathy with structural persistence in glaucomatous neurodegeneration
Crish, S. D., Sappington, R. M., Inman, D. M., Horner, P. J., & Calkins, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913141107 · Cited by 350
Mitochondrial Abnormalities in Patients with Primary Open-Angle Glaucoma
Abu-Amero, K. K., Morales, J., & Bosley, T. M. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-1639 · Cited by 337
Critical pathogenic events underlying progression of neurodegeneration in glaucoma
Calkins, D. J. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.07.001 · Cited by 309
Effect of CNTF on retinal ganglion cell survival in experimental glaucoma
Pease, M. E., Zack, D. J., Berlinicke, C., Bloom, K., Cone, F., Wang, Y., Klein, R. L., Hauswirth, W. W., & Quigley, H. A. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-3013 · Cited by 222
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Metadata
- Authors
- Quigley, H. A.
- Venue
- Progress in Retinal and Eye Research
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 18
- Issue
- 1
- Pages
- 39-57
- ISSN
- 1350-9462 (ISSN-L)
- OpenAlex
- W1984401984
- Cited by
- 790
- References
- 1
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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