The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Fullerene-based antioxidants and neurodegenerative disorders.
Abstract
Water-soluble derivatives of buckminsterfullerene (C(60)) derivatives are a unique class of compounds with potent antioxidant properties. Studies on one class of these compounds, the malonic acid C(60) derivatives (carboxyfullerenes), indicated that they are capable of eliminating both superoxide anion and H(2)O(2), and were effective inhibitors of lipid peroxidation, as well. Carboxyfullerenes demonstrated robust neuroprotection against excitotoxic, apoptotic and metabolic insults in cortical cell cultures. They were also capable of rescuing mesencephalic dopaminergic neurons from both MPP(+) and 6-hydroxydopamine-induced degeneration. Although there is limited in vivo data on these compounds to date, we have previously reported that systemic administration of the C(3) carboxyfullerene isomer delayed motor deterioration and death in a mouse model of familial amyotrophic lateral sclerosis (FALS). Ongoing studies in other animal models of CNS disease states suggest that these novel antioxidants are potential neuroprotective agents for other neurodegenerative disorders, including Parkinson's disease.
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“Neuroprotective compounds based on carbon-60 fullerene – the molecules having a 3-D pattern of evenly spaced carbon atoms, have been fabricated by the application of nanotechnological approach (Dugan et al., 2001).”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Dugan et al., 2001
In the citing paper
“Free radicals, such as superoxide, hydroxyl, peroxynitrite, and peroxide, cause deleterious alterations in cells including DNA fragmentation, peroxidation of cell membrane lipids, mitochondrial energy disturbances and alteration in functionality of transporter proteins”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Dugan et al., 2001
In the citing paper
“they are considered as the main culprit having the key role in pathology of neurodegenerative, ischemic, and traumatic CNS disorders (Mahadik and Mukherjee, 1996; Dugan et al., 2001).”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Dugan et al., 2001
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Carboxyfullerenes as neuroprotective agents
Dugan, L. L., Turetsky, D. M., Du, C., Lobner, D., Wheeler, M. E., Almli, C. R., Shen, C. K.-F., Luh, T., Choi, D. W., & Lin, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9434 · Cited by 747
Self-citationDistinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
Lotharius, J., Dugan, L. L., & O’Malley, K. L. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01284.1999 · Cited by 403
Self-citationDugan, L. L., Gabrielsen, J. K., Yu, S. P., Lin, T., & Choi, D. W. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0013 · Cited by 384
Self-citationCarboxyfullerene Prevents Iron‐Induced Oxidative Stress in Rat Brain
Lin, A. M.-Y., Chyi, B. Y., Wang, S. D., Yu, H., Kanakamma, P. P., Luh, T., Chou, C., & Ho, L. T. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.721634.x · Cited by 136
C 3 ‐Fullero‐ tris ‐Methanodicarboxylic Acid Protects Cerebellar Granule Cells from Apoptosis
Bisaglia, M., Natalini, B., Pellicciari, R., Straface, E., Malorni, W., Monti, D., Franceschi, D., & Schettini, G. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.741197.x · Cited by 94
Rapid microplate assay for superoxide scavenging efficiency
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Self-citationHuang, Y., Shen, C. K.-F., Luh, T., Yang, H. C., Hwang, K. C., & Chou, C. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2540038.x · Cited by 86
Inhibition of Nitric Oxide Synthase Isoforms by Tris-Malonyl-C60-Fullerene Adducts
Wolff, D. J., Papoiu, A. D. P., Mialkowski, K., Richardson, C. F., Schuster, D. I., & Wilson, S. R. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1843 · Cited by 59
Straface, E., Natalini, B., Monti, D., Franceschi, C., Schettini, G., Bisaglia, M., Fumelli, C., Pincelli, C., Pellicciari, R., & Malorni, W. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00812-1 · Cited by 52
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Metadata
- Authors
- Dugan, L. L., Lovett, E. G., Quick, K. L., Lotharius, J., Lin, T. T., & O'Malley, K. L.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Dugan, L.L.
- ORCID
- Dugan, L.L.
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 7
- Issue
- 3
- Pages
- 243-246
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W2126036130
- Cited by
- 338
- References
- 9
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 16 · 2023: 20 · 2022: 14 · 2021: 14 · 2020: 20 · 2019: 14 · 2018: 13 · 2017: 9 · 2016: 10 · 2015: 14 · 2014: 15 · 2013: 12 · 2012: 22
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parkinsonism & Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Fullerene Chemistry and Applications
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
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