Cited by 338Fullerene Chemistry and ApplicationsParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

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Fullerene-based antioxidants and neurodegenerative disorders.

Dugan, L.L., Lovett, E.G., Quick, K.L., Lotharius, J., Lin, T.T., O'Malley, K.L.·2001·Parkinsonism & Related Disorders

DOI 10.1016/s1353-8020(00)00064-x

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Abstract

Water-soluble derivatives of buckminsterfullerene (C(60)) derivatives are a unique class of compounds with potent antioxidant properties. Studies on one class of these compounds, the malonic acid C(60) derivatives (carboxyfullerenes), indicated that they are capable of eliminating both superoxide anion and H(2)O(2), and were effective inhibitors of lipid peroxidation, as well. Carboxyfullerenes demonstrated robust neuroprotection against excitotoxic, apoptotic and metabolic insults in cortical cell cultures. They were also capable of rescuing mesencephalic dopaminergic neurons from both MPP(+) and 6-hydroxydopamine-induced degeneration. Although there is limited in vivo data on these compounds to date, we have previously reported that systemic administration of the C(3) carboxyfullerene isomer delayed motor deterioration and death in a mouse model of familial amyotrophic lateral sclerosis (FALS). Ongoing studies in other animal models of CNS disease states suggest that these novel antioxidants are potential neuroprotective agents for other neurodegenerative disorders, including Parkinson's disease.

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Carboxyfullerenes as neuroprotective agents
Dugan, L. L., Turetsky, D. M., Du, C., Lobner, D., Wheeler, M. E., Almli, C. R., Shen, C. K.-F., Luh, T., Choi, D. W., & Lin, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9434 · Cited by 747
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Authors: Dugan, L. L., Lovett, E. G., Quick, K. L., Lotharius, J., Lin, T. T., & O'Malley, K. L.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Dugan, L.L.
ORCID: Dugan, L.L.
Venue: Parkinsonism & Related Disorders
Publisher: Elsevier BV
Published: 2001-07
Volume: 7
Issue: 3
Pages: 243-246
ISSN: 1353-8020 (ISSN-L)
DOI: 10.1016/s1353-8020(00)00064-x
OpenAlex: W2126036130
Cited by: 338
References: 9
Citations by year: 2026: 3 · 2025: 6 · 2024: 16 · 2023: 20 · 2022: 14 · 2021: 14 · 2020: 20 · 2019: 14 · 2018: 13 · 2017: 9 · 2016: 10 · 2015: 14 · 2014: 15 · 2013: 12 · 2012: 22
FWCI: 4.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Parkinsonism & Related Disorders (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Fullerene Chemistry and Applications
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments

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Fullerene-based antioxidants and neurodegenerative disorders.

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