The DOI matches its Crossref record; 124 of the 126 references it cites were found in a registry or an index.
The biology of the mammalian Krüppel-like family of transcription factors
Open accessAbstract
Recent advances in molecular cloning have led to the identification of a large number of mammalian zinc finger-containing transcription factors that exhibit homology to the Drosophila melanogaster protein, Krüppel. Although the amino acid sequences in the zinc finger domains of these Krüppel-like factors (KLFs) are closely related to one another, the regions outside the zinc fingers of the proteins are usually unique. KLFs display seemingly different and broad biological properties with each functioning as an activator of transcription, a repressor or both. This review article provides a current phylogenetic classification of the identified KLFs to date. More importantly, the currently known biological activities of the KLFs in regulating transcription, cell proliferation, differentiation and development are summarized and compared. Further characterization of this interesting protein family should provide additional insights into the their respective regulatory role in various important biological processes.
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“Zinc finger protein 681 contains a classical C 2 H 2 (Kruppel) zinc finger motif and functions as an activator and repressor of transcription, regulating proliferation, differentiation, and development.38,49”
From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [38]
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Cites
The Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,902
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
Mitchell, P. J., & Tjian, R. (1989) · Science · doi:10.1126/science.2667136 · Cited by 3,046
A model for p53-induced apoptosis
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500
Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.
Miller, J., McLachlan, A., & Klug, A. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03825.x · Cited by 2,476
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
Berg, J. M., & Shi, Y. (1996) · Science · doi:10.1126/science.271.5252.1081 · Cited by 1,930
Comparative Genomics of the Eukaryotes
Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698
Kadonaga, J. T., Carner, K., Masiarz, F. R., & Tjian, R. (1987) · Cell · doi:10.1016/0092-8674(87)90594-0 · Cited by 1,614
The Sp-family of transcription factors
Suske, G. (1999) · Gene · doi:10.1016/s0378-1119(99)00357-1 · Cited by 1,112
Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex
Côté, J., Quinn, J., Workman, J. L., & Peterson, C. L. (1994) · Science · doi:10.1126/science.8016655 · Cited by 861
Klf4 is a transcription factor required for establishing the barrier function of the skin
Segre, J. A., Bauer, C. R., & Fuchs, E. V. (1999) · Nature Genetics · doi:10.1038/11926 · Cited by 810
Research works printed but not linked: 1
- Perkins, 1997, Blood, 90, 575
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Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer
Black, A. R., Black, J. D., & Azizkhan‐Clifford, J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1111 · Cited by 1,048
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Sp1- and Krüppel-like transcription factors.
Kaczynski, J., Cook, T. A., & Urrutia, R. A. (2003) · Genome biology · doi:10.1186/gb-2003-4-2-206 · Cited by 976
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Metadata
- Authors
- Dang, D. T., Pevsner, J., & Yang, V. W.
- Affiliations
- Johns Hopkins University (US)
- Kennedy Krieger Institute (US)
- Corresponding author
- Yang, Vincent W.
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 32
- Issue
- 11-12
- Pages
- 1103-1121
- ISSN
- 1357-2725 (ISSN-L)
- PMC
- PMC2754176
- OpenAlex
- W2133383018
- Cited by
- 458
- References
- 126
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 16 · 2023: 22 · 2022: 7 · 2021: 12 · 2020: 15 · 2019: 17 · 2018: 29 · 2017: 16 · 2016: 10 · 2015: 14 · 2014: 18 · 2013: 21 · 2012: 18
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 84197, R01CA084197)
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK010020, DK 52230, DK10020, R01DK052230)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- Krüppel-like factors, zinc finger transcription factor, transcriptional regulation, transcriptional activator, transcriptional repressor, phylogenetic classification, cell proliferation, cell differentiation, development (biology)
- MeSH terms
- Animals, DNA-Binding Proteins, Humans, Mammals, Phylogeny, Repressor Proteins, Transcription Factors, Transcription, Genetic, Zinc Fingers, Kruppel-Like Transcription Factors
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