Comparative Genomics of the Eukaryotes
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A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
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To the authors' knowledge, this is the first genome-wide survey and comparison of conserved elements in different groups of eukaryotic species, excluding comparisons primarily of proteomes.
“To our knowledge, this is the first genome-wide survey and comparison of conserved elements in different groups of eukaryotic species (excluding comparisons primarily of proteomes; e.g., Rubin et al. 2000).”
From Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes (2005) · cites this paper as Rubin et al. 2000
Comparisons among fruit fly, nematode, and vertebrate genomes show greater genomic complexity in vertebrates as measured by gene content and structure, while many genes and networks are shared across bilaterians.
“Comparisons (4-6) between fruit fly, nematode, and vertebrate genomes reveal greater genomic complexity in the vertebrates (and other deuterostomes (7,8)) as measured by gene content and structure, but at the same time show that many genes and networks are shared across bilaterians.”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [4]
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Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289 · see citing works
Self-citationThe Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,902 · see citing works
Self-citationWhole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd
Fleischmann, R. D., Adams, M. D., White, O. R., Clayton, R. A., Kirkness, E. F., Kerlavage, A. R., Bult, C. J., Tomb, J.-F., Dougherty, B. A., Merrick, J. M., et al. (1995) · Science · doi:10.1126/science.7542800 · Cited by 5,641 · see citing works
Self-citationInduction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167 · see citing works
Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology
Berg, J. (1998) · Science · doi:10.1126/science.282.5396.2012 · Cited by 4,458 · see citing works
Goffeau, A., Barrell, B., Bussey, H., Davis, R. W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J., Jacq, C., Johnston, M., et al. (1996) · Science · doi:10.1126/science.274.5287.546 · Cited by 4,420 · see citing works
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060 · see citing works
BCL-2 family members and the mitochondria in apoptosisPreprint
Gross, A., McDonnell, J. M., & Korsmeyer, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.15.1899 · Cited by 3,623 · see citing works
The SWISS-PROT protein sequence data bank and its supplement TrEMBL
Bairoch, A., & Apweiler, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.1.31 · Cited by 3,594 · see citing works
Self-citationThe SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1998
Bairoch, A. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.1.38 · Cited by 3,275 · see citing works
SNAP receptors implicated in vesicle targeting and fusion
Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239 · see citing works
The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000
Bairoch, A. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.45 · Cited by 3,118 · see citing works
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.383 · Cited by 2,758 · see citing works
Handbook of Proteolytic Enzymes
(2004) · Elsevier eBooks · doi:10.1016/c2009-0-03628-9 · Cited by 2,627 · see citing works
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567 · see citing works
Innate Immunity: The Virtues of a Nonclonal System of Recognition
Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434 · see citing works
Zhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626 · see citing works
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
Jones, S. N., Roe, A. E., Donehower, L. A., & Bradley, A. (1995) · Nature · doi:10.1038/378206a0 · Cited by 1,280 · see citing works
Self-citationMembrane fusion and exocytosis.
Jahn, R., & Südhof, T. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.863 · Cited by 1,253 · see citing works
Hengartner, M. O., & Horvitz, H. R. (1994) · Cell · doi:10.1016/0092-8674(94)90506-1 · Cited by 1,167 · see citing works
A Spatial Map of Olfactory Receptor Expression in the Drosophila Antenna
Vosshall, L. B., Amrein, H., Morozov, P. S., Rzhetsky, A., & Axel, R. (1999) · Cell · doi:10.1016/s0092-8674(00)80582-6 · Cited by 1,166 · see citing works
Self-citationA Novel Family of Divergent Seven-Transmembrane Proteins
Clyne, P. J., Warr, C. G., Freeman, M. R., Lessing, D., Kim, J., & Carlson, J. R. (1999) · Neuron · doi:10.1016/s0896-6273(00)81093-4 · Cited by 1,155 · see citing works
The PROSITE database, its status in 1999
Hofmann, K., Bücher, P., Falquet, L., & Bairoch, A. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.215 · Cited by 1,092 · see citing works
Gene duplications and the origins of vertebrate development
Holland, P. W. H., García‐Fernàndez, J., Williams, N. A., & Sidow, A. (1994) · Development · doi:10.1242/dev.1994.supplement.125 · Cited by 951 · see citing works
Neurobiology of the <i>Caenorhabditis elegans</i> Genome
Bargmann, C. I. (1998) · Science · doi:10.1126/science.282.5396.2028 · Cited by 929 · see citing works
A CONSERVED SIGNALING PATHWAY: The <i>Drosophila</i> Toll-Dorsal Pathway
Belvin, M. P., & Anderson, K. V. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.393 · Cited by 836 · see citing works
Warrick, J. M., Chan, H. Y. E., Gladys L. Gray-Board, Chai, Y., Paulson, H. L., & Bonini, N. M. (1999) · Nature Genetics · doi:10.1038/70532 · Cited by 830 · see citing works
Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah
Lin, Y.-J., Seroude, L., & Benzer, S. (1998) · Science · doi:10.1126/science.282.5390.943 · Cited by 804 · see citing works
A Striking Organization of a Large Family of Human Neural Cadherin-like Cell Adhesion Genes
Wu, Q., & Maniatis, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80789-8 · Cited by 714 · see citing works
Kin I kinesins are microtubule-destabilizing enzymes
Desai, A., Verma, S., Mitchison, T. J., & Walczak, C. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80960-5 · Cited by 708 · see citing works
Mueller, P. R., Coleman, T. R., Kumagai, A., & Dunphy, W. G. (1995) · Science · doi:10.1126/science.270.5233.86 · Cited by 698 · see citing works
Toll signaling pathways in the innate immune response.
Anderson, K. V. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00045-x · Cited by 677 · see citing works
Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila
Warrick, J. M., Paulson, H. L., Gladys L Gray-Board, Bui, Q. T., Fischbeck, K. H., Pittman, R. N., & Bonini, N. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81200-3 · Cited by 669 · see citing works
Neuroligin 1: A splice site-specific ligand for β-neurexins
Ichtchenko, K., Hata, Y., Nguyen, T., Ullrich, B., Missler, M., Moomaw, C. R., & Südhof, T. C. (1995) · Cell · doi:10.1016/0092-8674(95)90396-8 · Cited by 663 · see citing works
The world according to bedgebog
Hammerschmidt, M., Brook, A., & McMahon, A. P. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(96)10051-2 · Cited by 542 · see citing works
Jackson, G. R., Salecker, I., Dong, X., Yao, X., Arnheim, N., Faber, P. W., MacDonald, M. E., & Zipursky, S. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80573-5 · Cited by 535 · see citing works
Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins
Bateman, A. G., Birney, E., Durbin, R. M., Eddy, S. R., Finn, R. D., & Sonnhammer, E. L. L. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.260 · Cited by 507 · see citing works
Self-citationA peptidoglycan recognition protein in innate immunity conserved from insects to humans
Kang, D., Liu, G., Lundström, A., Gelius, E., & Steiner, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10078 · Cited by 481 · see citing works
Seven-Transmembrane Proteins as Odorant and Chemosensory Receptors
Mombaerts, P. (1999) · Science · doi:10.1126/science.286.5440.707 · Cited by 446 · see citing works
Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence
Chervitz, S. A., Aravind, L., Sherlock, G. J., Ball, C. A., Koonin, E. V., Dwight, S. S., Harris, M. A., Dolinski, K. J., Mohr, S. C., Smith, T. F., et al. (1998) · Science · doi:10.1126/science.282.5396.2022 · Cited by 436 · see citing works
Self-citationAcinus is a caspase-3-activated protein required for apoptotic chromatin condensation
Sahara, S., Aoto, M., Eguchi, Y., Imamoto, N., Yoneda, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/43678 · Cited by 431 · see citing works
Cell adhesion: old and new questions
Hynes, R. O. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01667-0 · Cited by 427 · see citing works
Self-citationHunter, T. R. (1998) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1998.0228 · Cited by 409 · see citing works
Croquemort, A Novel Drosophila Hemocyte/Macrophage Receptor that Recognizes Apoptotic Cells
Franc, N. C., Dimarcq, J., Lagueux, M., Hoffmann, J. A., & Ezekowitz, R. A. B. (1996) · Immunity · doi:10.1016/s1074-7613(00)80410-0 · Cited by 397 · see citing works
Guidebook to the cytoskeletal and motor proteins
(1994) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(94)90276-3 · Cited by 379 · see citing works
Glutamine repeats and neurodegenerative diseases: molecular aspects
Perutz, M. F. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01350-4 · Cited by 372 · see citing works
An exegesis of IAPs: salvation and surprises from BIR motifs
Miller, L. K. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01609-8 · Cited by 370 · see citing works
Glutamine Repeats and Neurodegenerative Diseases: Molecular Aspects
Suchowersky, O. (2002) · Archives of Neurology · doi:10.1001/archneur.59.6.1038 · Cited by 356 · see citing works
Increased coverage of protein families with the Blocks Database servers
Henikoff, J. G. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.228 · Cited by 333 · see citing works
Structure and distribution of modules in extracellular proteins
Peer Bork, B., Downing, A. K., Kieffer, B., & Campbell, I. D. (1996) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500005783 · Cited by 324 · see citing works
Costa, M. A., Wilson, E. T., & Wieschaus, E. F. (1994) · Cell · doi:10.1016/0092-8674(94)90384-0 · Cited by 319 · see citing works
Scavenger receptors in innate immunity
Pearson, A. M. (1996) · Current Opinion in Immunology · doi:10.1016/s0952-7915(96)80100-2 · Cited by 315 · see citing works
Lu, X., & Horvitz, H. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81722-5 · Cited by 313 · see citing works
The Taxonomy of Developmental Control in <i>Caenorhabditis elegans</i>
Ruvkun, G., & Hobert, O. (1998) · Science · doi:10.1126/science.282.5396.2033 · Cited by 305 · see citing works
Vertebrate evolution by interspecific hybridisation – are we polyploid?
Spring, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01351-8 · Cited by 297 · see citing works
Plowman, G. D., Sudarsanam, S., Bingham, J., Whyte, D. B., & Hunter, T. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13603 · Cited by 278 · see citing works
Proteins of the CNR Family Are Multiple Receptors for Reelin
Senzaki, K., Ogawa, M., & Yagi, T. (1999) · Cell · doi:10.1016/s0092-8674(00)81552-4 · Cited by 272 · see citing works
RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.Preprint
Du, W., Vidal, M., Xie, J. E., & Dyson, N. J. (1996) · Genes & Development · doi:10.1101/gad.10.10.1206 · Cited by 258 · see citing works
gigas, a Drosophila Homolog of Tuberous Sclerosis Gene Product-2, Regulates the Cell Cycle
Ito, N., & Rubin, G. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80657-1 · Cited by 258 · see citing works
Self-citationRescue of a Drosophila NF1 Mutant Phenotype by Protein Kinase A
The, I., Hannigan, G. E., Cowley, G. S., Reginald, S., Zhong, Y., Gusella, J. F., Hariharan, I. K., & Bernards, A. (1997) · Science · doi:10.1126/science.276.5313.791 · Cited by 257 · see citing works
Self-citationLee, W., Lee, J. D., Kravchenko, V. V., Ulevitch, R. J., & Brey, P. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7888 · Cited by 211 · see citing works
Dutcher, S. K., & Trabuco, E. C. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.6.1293 · Cited by 211 · see citing works
Guidebook to the Cytoskeletal and Motor Proteins
(1999) · doi:10.1093/oso/9780198599579.001.0001 · Cited by 211 · see citing works
Hergannan, J. A., & Rechhart, J.-V. (1997) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01087-8 · Cited by 181 · see citing works
Kinectin, an Essential Anchor for Kinesin-Driven Vesicle Motility
Kumar, J., Yu, H., & Sheetz, M. P. (1995) · Science · doi:10.1126/science.7892610 · Cited by 159 · see citing works
DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.
Dynlacht, B. D., Brook, A., Dembski, M., Yenush, L., & Dyson, N. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6359 · Cited by 157 · see citing works
Chang, P., & Stearns, T. (1999) · Nature Cell Biology · doi:10.1038/71350 · Cited by 153 · see citing works
Synaptic function modulated by changes in the ratio of synaptotagmin I and IV
Littleton, J. T., Serano, T. L., Rubin, G. M., Ganetzky, B., & Chapman, E. R. (1999) · Nature · doi:10.1038/23462 · Cited by 151 · see citing works
Self-citationAn emerging blueprint for apoptosis in Drosophila
Abrams, J. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01646-3 · Cited by 150 · see citing works
Hauser, F., Nothacker, H., & Grimmelikhuijzen, C. J. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.1002 · Cited by 126 · see citing works
Scythe: a novel reaper‐binding apoptotic regulator
Thress, K. S., Henzel, W. J., Shillinglaw, W., & Kornbluth, S. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6135 · Cited by 126 · see citing works
PRINTS prepares for the new millennium
Attwood, T. K., Flower, D. R., Lewis, A., Gilsenan, J. M., Morgan, S. R., Scordis, P., Selley, J. N., & Wright, W. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.220 · Cited by 125 · see citing works
Stress signaling in Drosophila
Stronach, B. E., & Perrimon, N. (1999) · Oncogene · doi:10.1038/sj.onc.1203125 · Cited by 120 · see citing works
Signal transduction by a protease cascade
LeMosy, E. K., Hong, C. C., & Hashimoto, C. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01494-9 · Cited by 118 · see citing works
A screen for fast evolving genes from Drosophila
Schmid, K. J., & Tautz, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9746 · Cited by 109 · see citing works
Caspase activation without death
Zeuner, A., Eramo, A., Peschle, C., & Maria, R. D. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400596 · Cited by 104 · see citing works
Blurton-Jones, M. M., Roberts, J. A., & Tuszynski, M. H. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990322)405:4 · Cited by 94 · see citing works
Vertebrate evolution: recent perspectives from fish
Aparicio, S. A. J. R. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01934-4 · Cited by 92 · see citing works
Colas, J., Launay, J., Vonesch, J., Hickel, P., & Maroteaux, L. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00141-0 · Cited by 90 · see citing works
An evolutionary view of drug-receptor interaction: the bioamine receptor family
Vernier, P. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)89078-1 · Cited by 87 · see citing works
Ventralizing signal determined by protease activation in Drosophila embryogenesis
Smith, C. L., & DeLotto, R. (1994) · Nature · doi:10.1038/368548a0 · Cited by 75 · see citing works
Konrad, K. D., Goralski, T. J., Mahowald, A. P., & Marsh, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6819 · Cited by 64 · see citing works
dE2F2, a Novel E2F-Family Transcription Factor inDrosophila melanogaster
Sawado, T., Yamaguchi, M., Nishimoto, Y., Ohno, K., Sakaguchi, K., & Matsukage, A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9407 · Cited by 63 · see citing works
Comparative aspects of Notch signaling in lower and higher eukaryotes.
Blaumueller, C. M., & Artavanis‐Tsakonas, S. (1997) · PubMed · Cited by 42 · see citing works
Capdevila, J., & Belmonte, J. C. I. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80065-3 · Cited by 39 · see citing works
Paradigms to Study Signal Transduction Pathways in Drosophila
Engstrom, L., Noll, E., & Perrimon, N. (1997) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60261-6 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 87 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [13]Hynes RO. Trends Cell Biol. 1999;9:M33. [PubMed] [Google Scholar]
- [54]Miklos GLG. J Am Acad Arts Sci. 1998;127:197. [Google Scholar]
Cited by
Sorted by citations
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
Self-citationInitial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909 · see citing works
Self-citationAnalysis of the genome sequence of the flowering plant Arabidopsis thaliana
Initiative, T. A. G. (2000) · Nature · doi:10.1038/35048692 · Cited by 9,301 · see citing works
The protein kinase complement of the human genome
Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145 · see citing works
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187 · see citing works
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542 · see citing works
The Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,902 · see citing works
Self-citationOrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
Li, L., Stoeckert, C. J., & Roos, D. S. (2003) · Genome Research · doi:10.1101/gr.1224503 · Cited by 5,707 · see citing works
The Evolutionary Fate and Consequences of Duplicate Genes
Lynch, M., & Conery, J. S. (2000) · Science · doi:10.1126/science.290.5494.1151 · Cited by 4,988 · see citing works
Functional organization of the yeast proteome by systematic analysis of protein complexes
Gavin, A., Böesche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A., Cruciat, C., et al. (2002) · Nature · doi:10.1038/415141a · Cited by 4,729 · see citing works
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
Siepel, A., Bejerano, G., Pedersen, J. S., Hinrichs, A. S., Hou, M., Rosenbloom, K., Clawson, H., Spieth, J., Hillier, L. W., Richards, S., et al. (2005) · Genome Research · doi:10.1101/gr.3715005 · Cited by 4,408 · see citing works
“Secondary structure in noncoding HCEs Because several known mechanisms for post-transcriptional regulation involve stem-loop (and other) structures in UTRs ( Ross 1996; Mignone et al. 2002), strong conservation in UTRs may occur partly as a result of structural constraints.”
BackgroundSelf-citationThe TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650 · see citing works
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,542 · see citing works
An efficient algorithm for large-scale detection of protein families
Enright, A. J. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.7.1575 · Cited by 3,536 · see citing works
Hopkins, A. L., & Groom, C. R. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd892 · Cited by 3,305 · see citing works
The host defense of Drosophila melanogaster.
Lemaître, B., & Hoffmann, J. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141615 · Cited by 3,404 · see citing works
Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes
Riechmann, J. L., Heard, J. E., Martin, G., Reuber, T. L., Jiang, C., Keddie, J. S., Adam, L., Pineda, O., Ratcliffe, O. J., Samaha, R. R., et al. (2000) · Science · doi:10.1126/science.290.5499.2105 · Cited by 2,801 · see citing works
Self-citationEvolution by gene duplication: An update
Zhang, J. (2003) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(03)00033-8 · Cited by 2,201 · see citing works
Self-citationThe Genome Sequence of the Malaria Mosquito Anopheles gambiae
Holt, R. A., Subramanian, G., Halpern, A. L., Sutton, G. G., Charlab, R., Nusskern, D. R., Wincker, P., Clark, A. G., Ribeiro, J. M. C., Wides, R., et al. (2002) · Science · doi:10.1126/science.1076181 · Cited by 2,018 · see citing works
Self-citationMAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes.Preprint
Cantarel, B., Korf, I., Robb, S. M. C., Parra, G., Ross, E. J., Moore, B., Holt, C., Alvarado, A. S., & Yandell, M. (2007) · Genome Research · doi:10.1101/gr.6743907 · Cited by 1,909 · see citing works
“Following procedures similar to those used to annotate other eukaryotic genomes (Rubin et al. 2000; Venter et al. 2001), we next sought to assemble a high-confidence (HC) gene set from among the 65,563 MAKER genes.”
MethodSelf-citationPrescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?
Juma, S., Imrhan, V., Vijayagopal, P., & Prasad, C. (2014) · Lifestyle Genomics · doi:10.1159/000370213 · Cited by 1,905 · see citing works
The Diploid Genome Sequence of an Individual Human
Levy, S., Sutton, G., Ng, P. C., Feuk, L., Halpern, A. L., Walenz, B. P., Axelrod, N., Huang, J., Kirkness, E. F., Denisov, G., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050254 · Cited by 1,778 · see citing works
Self-citationFunctional genomic analysis of C. elegans chromosome I by systematic RNA interference
Fraser, A. G., Kamath, R. S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M., & Ahringer, J. (2000) · Nature · doi:10.1038/35042517 · Cited by 1,720 · see citing works
The Conformational Plasticity of Protein Kinases
Huse, M., & Kuriyan, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00741-9 · Cited by 1,760 · see citing works
The genome sequence of Schizosaccharomyces pombe
Wood, V., Gwilliam, R., Rajandream, M.-A., Lyne, M. H., Lyne, R., Stewart, A., SGOUROS, J. G., Peat, N., Hayles, J., Baker, S. G., et al. (2002) · Nature · doi:10.1038/nature724 · Cited by 1,650 · see citing works
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555 · see citing works
A Whole-Genome Assembly of Drosophila
Myers, E. W., Sutton, G. G., Delcher, A. L., Dew, I. M., Fasulo, D., Flanigan, M. J., Kravitz, S. A., Mobarry, C. M., Reinert, K., Remington, K., et al. (2000) · Science · doi:10.1126/science.287.5461.2196 · Cited by 1,533 · see citing works
Self-citationThe developmental transcriptome of Drosophila melanogaster
Graveley, B. R., Brooks, A. N., Carlson, J. W., Duff, M. O., Landolin, J. M., Yang, L. C., Artieri, C. G., van Baren, M. J., Boley, N. P., Booth, B. W., et al. (2010) · Nature · doi:10.1038/nature09715 · Cited by 1,487 · see citing works
Self-citationAutomatic clustering of orthologs and in-paralogs from pairwise species comparisons
Remm, M., Storm, C. E. V., & Sonnhammer, E. L. L. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.5197 · Cited by 1,175 · see citing works
“The A-B sequence pairs are eliminated if either sequence A or sequence B scores higher to outgroup sequence than they score to each other (3, 4 ).”
BackgroundMethodInfluentialThe genome of the social amoeba Dictyostelium discoideum
Eichinger, L., Pachebat, J. A., Glöckner, G., Rajandream, M.-A., Sucgang, R., Berriman, M., Song, J., Olsen, R., Szafranski, K., Xu, Q., et al. (2005) · Nature · doi:10.1038/nature03481 · Cited by 1,351 · see citing works
Self-citationA Draft Sequence for the Genome of the Domesticated Silkworm ( Bombyx mori )
Biology analysis group, Xia, Q., Zhou, Z., Lu, C., Cheng, D., Dai, F., Li, B., Zhao, P., Zha, X., Cheng, T., et al. (2004) · Science · doi:10.1126/science.1102210 · Cited by 1,121 · see citing works
Self-citationDrosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity
Schmucker, D., Clemens, J. C., Shu, H., Worby, C. A., Xiao, J. Y., Muda, M., Dixon, J. E., & Zipursky, S. L. (2000) · Cell · doi:10.1016/s0092-8674(00)80878-8 · Cited by 1,105 · see citing works
An Olfactory Sensory Map in the Fly Brain
Vosshall, L. B., Wong, A. M., & Axel, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00021-0 · Cited by 1,090 · see citing works
Self-citationApweiler, R. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.1.37 · Cited by 1,079 · see citing works
Self-citationRhodes, D. R., Yu, J., Sundaram, S. K., Deshpande, N., Varambally, R., Ghosh, D., Barrette, T. R., Pandey, A., & Chinnaiyan, A. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401994101 · Cited by 1,010 · see citing works
A Systematic Analysis of Human Disease-Associated Gene Sequences In Drosophila melanogasterPreprint
Reiter, L. T., Potocki, L., Chien, S., Gribskov, M., & Bier, E. (2001) · Genome Research · doi:10.1101/gr.169101 · Cited by 1,000 · see citing works
The Promise and Perils of Wnt Signaling Through β-Catenin
Moon, R. T., Bowerman, B. A., Boutros, M., & Perrimon, N. (2002) · Science · doi:10.1126/science.1071549 · Cited by 970 · see citing works
Gene Expression During the Life Cycle of Drosophila melanogaster
Arbeitman, M. N., Furlong, E. E. M., Imam, F. B., Johnson, E. A., Null, B. H., Baker, B. S., Krasnow, M. A., Scott, M. P., Davis, R. W., & White, K. P. (2002) · Science · doi:10.1126/science.1072152 · Cited by 926 · see citing works
Non‐coding RNAs: the architects of eukaryotic complexity
Mattick, J. S. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve230 · Cited by 848 · see citing works
CAFE 5 models variation in evolutionary rates among gene families
Mendes, F. K., Vanderpool, D., Fulton, B., & Hahn, M. W. (2021) · Bioinformatics · doi:10.1093/bioinformatics/btaa1022 · Cited by 833 · see citing works
SH3 domains: complexity in moderation
Mayer, B. J. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.7.1253 · Cited by 788 · see citing works
Alternative pre-mRNA splicing and proteome expansion in metazoans
Maniatis, T., & Tasic, B. (2002) · Nature · doi:10.1038/418236a · Cited by 768 · see citing works
Rho family proteins: coordinating cell responses
Ridley, A. J. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02153-5 · Cited by 767 · see citing works
A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila.
Scott, K., Brady, R., Cravchik, A., Morozov, P., Rzhetsky, A., Zuker, C., & Axel, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00263-x · Cited by 720 · see citing works
Self-citationDesign and Selection of Novel Cys2His2 Zinc Finger Proteins
Pabo, C. O., Peisach, E., & Grant, R. A. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.313 · Cited by 715 · see citing works
Specificities of heparan sulphate proteoglycans in developmental processes
Perrimon, N., & Bernfield, M. R. (2000) · Nature · doi:10.1038/35008000 · Cited by 713 · see citing works
A genomic perspective on membrane compartment organization
Bock, J. B., Matern, H. T., Peden, A. A., & Scheller, R. H. (2001) · Nature · doi:10.1038/35057024 · Cited by 696 · see citing works
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays
Gregorio, E. D., Spellman, P. T., Rubin, G. M., & Lemaître, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221458698 · Cited by 691 · see citing works
Self-citationMolecular Biologist's Guide to Proteomics
Graves, P. R., & Haystead, T. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.1.39-63.2002 · Cited by 691 · see citing works
The evolution and genetics of innate immunity
Kimbrell, D., & Beutler, B. (2001) · Nature reviews genetics · doi:10.1038/35066006 · Cited by 679 · see citing works
Functional annotation of a full-length mouse cDNA collection
Kawai, J., Shinagawa, A., Shibata, K., Yoshino, M., Itoh, M., Ishii, Y., Arakawa, T., Hara, A., Fukunishi, Y., Konno, H., et al. (2001) · Nature · doi:10.1038/35055500 · Cited by 665 · see citing works
“To find orthologues of human disease genes in the RIKEN cDNA set, we compared the clones to 288 human disease gene orthologues compiled for the Drosophila genome sequence pape”
MethodSelf-citationERK1/2 MAP kinases in cell survival and apoptosis
Lu, Z., & Xu, S. (2006) · IUBMB Life · doi:10.1080/15216540600957438 · Cited by 654 · see citing works
Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex
Schulman, B. A., Carrano, A. C., Jeffrey, P. D., Bowen, Z., Kinnucan, E., Finnin, M. S., Elledge, S. J., Harper, J. W., Pagano, M., & Pavletich, N. P. (2000) · Nature · doi:10.1038/35042620 · Cited by 610 · see citing works
“elegans and Drosophila melanogaster contain at least 17 and 7 Skp1-like sequences, respectivel”
BackgroundToll-like receptors — taking an evolutionary approach
Leulier, F., & Lemaitre, B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2303 · Cited by 581 · see citing works
The C. elegans model in toxicity testing
Hunt, P. R. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3357 · Cited by 587 · see citing works
“Moreover, given that the majority of cancer genes have a C. elegans ortholog (Rubin et al., 2000) and that conserved processes such as apoptosis are required for evading tumorigenesis, it is possible that many human carcinogens could be identified in C. elegans by screening for alterations in the…”
BackgroundMATHEMATICAL CONSEQUENCES OF THE GENEALOGICAL SPECIES CONCEPT
Hudson, R. R., & Coyne, J. A. (2002) · Evolution · doi:10.1111/j.0014-3820.2002.tb01467.x · Cited by 579 · see citing works
A <i>Drosophila</i> fragile X protein interacts with components of RNAi and ribosomal proteins
Ishizuka, A., Siomi, M. C., & Siomi, H. (2002) · Genes & Development · doi:10.1101/gad.1022002 · Cited by 486 · see citing works
Comparative Genomics and Molecular Dynamics of DNA Repeats in Eukaryotes
Richard, G., Kerrest, A., & Dujon, B. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00011-08 · Cited by 549 · see citing works
Neuropeptides and Neuropeptide Receptors in the Drosophila melanogaster GenomePreprint
Hewes, R. S., & Taghert, P. H. (2001) · Genome Research · doi:10.1101/gr.169901 · Cited by 541 · see citing works
OrthoVenn3: an integrated platform for exploring and visualizing orthologous data across genomes
Sun, J., Lü, F., Luo, Y., Bie, L., Xu, L., & Wang, Y. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad313 · Cited by 536 · see citing works
Chance and necessity: the evolution of morphological complexity and diversity
Carroll, S. B. (2001) · Nature · doi:10.1038/35059227 · Cited by 531 · see citing works
Loss of Protein Structure Stability as a Major Causative Factor in Monogenic Disease
Yue, P., Li, Z. A., & Moult, J. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.08.020 · Cited by 518 · see citing works
Self-citationPanorama of ancient metazoan macromolecular complexes
Wan, C., Borgeson, B., Phanse, S., Tu, F., Drew, K., Clark, G. W., Xiong, X., Kagan, O., Kwan, J., Bezginov, A., et al. (2015) · Nature · doi:10.1038/nature14877 · Cited by 521 · see citing works
New developments in the InterPro database
Mulder, N., Apweiler, R., Attwood, T. K., Bairoch, A., Bateman, A. G., Binns, D., Peer Bork, B., Buillard, V., Cerutti, L., Copley, R. R., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl841 · Cited by 508 · see citing works
Self-citationThe Role of Lineage-Specific Gene Family Expansion in the Evolution of EukaryotesPreprint
Lespinet, O., Wolf, Y. I., Koonin, E. V., & Aravind, L. (2002) · Genome Research · doi:10.1101/gr.174302 · Cited by 506 · see citing works
A genomic perspective on plant transcription factors
Riechmann, J. L., & Ratcliffe, O. J. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)00107-2 · Cited by 504 · see citing works
Mattick, J. S., & Gagen, M. J. (2001) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003951 · Cited by 505 · see citing works
“…and some bacteria, despite these animals’ every appearance of possessing more than twice the complexity of micro-organisms (Chervitz et al. 1998; Rubin et al. 2000), leading to the conclusion that ‘‘the evolution of additional complex attributes is essentially an organizational one; a matter…”
BackgroundInfluentialJunctional adhesion molecules (JAMs): more molecules with dual functions?
Ebnet, K., Suzuki, A., Ohno, S., & Vestweber, D. (2003) · Journal of Cell Science · doi:10.1242/jcs.00930 · Cited by 501 · see citing works
Extent of Gene Duplication in the Genomes of Drosophila, Nematode, and Yeast
Gu, Z., Cavalcanti, A. R. O., Chen, F., Bouman, P., & Li, W. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a004079 · Cited by 496 · see citing works
“Using the BLASTP E value as the sole criterion for identifying homologous proteins, Rubin et al. (2000) studied the extents of gene duplication in yeast, Drosophila, and C. elegans genomes.”
MethodThe evolution of signalling pathways in animal development
Pires-daSilva, A., & Sommer, R. J. (2003) · Nature Reviews Genetics · doi:10.1038/nrg977 · Cited by 466 · see citing works
The Evolution of Cell Adhesion
Hynes, R. O., & Zhao, Q. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.2.f89 · Cited by 487 · see citing works
Self-citationThe Unicellular Ancestry of Animal Development
King, N. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.010 · Cited by 482 · see citing works
Nässel, D. R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00057-6 · Cited by 482 · see citing works
Ion Channels and Synaptic Organization
Littleton, J. T., & Ganetzky, B. (2000) · Neuron · doi:10.1016/s0896-6273(00)81135-6 · Cited by 477 · see citing works
Self-citationGenome-Wide Analysis of the Odorant-Binding Protein Gene Family in Drosophila melanogasterPreprint
Hekmat‐Scafe, D. S., Scafe, C., McKinney, A., & Tanouye, M. A. (2002) · Genome Research · doi:10.1101/gr.239402 · Cited by 465 · see citing works
Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance
Derry, W. B., Putzke, A. P., & Rothman, J. H. (2001) · Science · doi:10.1126/science.1065486 · Cited by 464 · see citing works
McCarroll, S. A., Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C.-S., Jan, Y. N., Kenyon, C., Bargmann, C. I., & Li, H. (2004) · Nature Genetics · doi:10.1038/ng1291 · Cited by 454 · see citing works
The biology of the mammalian Krüppel-like family of transcription factors
Dang, D. T., Pevsner, J., & Yang, V. W. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00059-5 · Cited by 458 · see citing works
The Basic Helix-Loop-Helix Protein Family: Comparative Genomics and Phylogenetic AnalysisPreprint
Ledent, V., & Vervoort, M. (2001) · Genome Research · doi:10.1101/gr.177001 · Cited by 455 · see citing works
Kamal, A., Stokin, G. B., Yang, Z., Xia, C.-H., & Goldstein, L. S. B. (2000) · Neuron · doi:10.1016/s0896-6273(00)00124-0 · Cited by 544 · see citing works
Self-citationThe neprilysin (NEP) family of zinc metalloendopeptidases: Genomics and function
Turner, A. J., Isaac, R. E., & Coates, D. (2001) · BioEssays · doi:10.1002/1521-1878(200103)23:3 · Cited by 450 · see citing works
Self-citationSticky fingers: zinc-fingers as protein-recognition motifs
Gamsjaeger, R., LIEW, C., Loughlin, F. E., Crossley, M., & Mackay, J. P. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.12.007 · Cited by 451 · see citing works
Fibronectins, Their Fibrillogenesis, and In Vivo FunctionsPreprint
Schwarzbauer, J. E., & DeSimone, D. W. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005041 · Cited by 445 · see citing works
“FN-like genes have yet to be identified for any protostome (Hynes and Zhao 2000; Rubin et al. 2000) or nonchordate deuterostome (Whittaker et al. 2006; Tucker and Chiquet-Ehrismann 2009).”
BackgroundInfectious Diseases: Considerations for the 21st Century
Fauci, A. S. (2001) · Clinical Infectious Diseases · doi:10.1086/319235 · Cited by 443 · see citing works
Experimental annotation of the human genome using microarray technology
Shoemaker, D. D., Schadt, E. E., Armour, C. D., He, Y. D., Garrett-Engele, P. W., MCDONAGH, P. D., Loerch, P., Leonardson, A. S., Lum, P. Y., Cavet, G., et al. (2001) · Nature · doi:10.1038/35057141 · Cited by 440 · see citing works
Self-citationConvergent projections of Drosophila olfactory neurons to specific glomeruli in the antennal lobe
Gao, Q., Yuan, B., & Chess, A. J. (2000) · Nature Neuroscience · doi:10.1038/77680 · Cited by 432 · see citing works
Ranson, H., Rossiter, L. C., Ortelli, F., Jensen, B., Wang, X., Roth, C. W., Collins, F. H., & Hemingway, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590295 · Cited by 437 · see citing works
Quantitative trait loci in Drosophila
Mackay, T. F. C. (2001) · Nature Reviews Genetics · doi:10.1038/35047544 · Cited by 425 · see citing works
A New Method to Detect Related Function Among Proteins Independent of Sequence and Fold Homology
Schmitt, S., Kühn, D., & Klebe, G. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00811-2 · Cited by 423 · see citing works
“by nodes (a [ A and b [ B) and edges (d(ai ;a j) and d(bk ;b l)) that describe two cavities A and B, a new graph G can be defined according to the following protocol: ( 1 ) construct pairs between nodes taken from A and B, in such a way that the nodes (ai and bk) correspond to the same property, i.e.”
BackgroundInfluentialDrosophila as a Model for Human Neurodegenerative Disease
Bilen, J., & Bonini, N. M. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095804 · Cited by 420 · see citing works
Zinke, I., Schütz, C. S., Katzenberger, J. D., Bauer, M. F., & Pankratz, M. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf600 · Cited by 422 · see citing works
Energy Constraints on the Evolution of Gene Expression
Wagner, A. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi126 · Cited by 419 · see citing works
“Between 30% and 50% of a eukaryotic genome’s gene content consists of duplicated genes (Rubin et al. 2000; Conant and Wagner 2002).”
BackgroundMicroRNAs and the regulation of cell death
Xu, P., Guo, M., & Hay, B. A. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.09.010 · Cited by 416 · see citing works
Self-citationDissecting Human Disease in the Postgenomic Era
Peltonen, L., & McKusick, V. A. (2001) · Science · doi:10.1126/science.291.5507.1224 · Cited by 414 · see citing works
Met receptor tyrosine kinase: enhanced signaling through adapter proteins
Furge, K. A., Zhang, Y.-W., & Woude, G. F. V. (2000) · Oncogene · doi:10.1038/sj.onc.1203859 · Cited by 412 · see citing works
Ku, H., Vision, T., Liu, J., & Tanksley, S. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160271297 · Cited by 408 · see citing works
Highwire Regulates Synaptic Growth in Drosophila
Wan, H. I., DiAntonio, A., Fetter, R. D., Bergstrom, K., Strauß, R., & Goodman, C. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)81166-6 · Cited by 398 · see citing works
Li, S. S. ‐. (2005) · Biochemical Journal · doi:10.1042/bj20050411 · Cited by 401 · see citing works
Jiménez‐Sánchez, G., Childs, B., & Valle, D. L. (2001) · Nature · doi:10.1038/35057050 · Cited by 381 · see citing works
- Authors
- Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., Fleischmann, W., Cherry, J. M., Henikoff, S., Skupski, M. P., Misra, S., Ashburner, M., Birney, E., Boguski, M. S., Brody, T., Brokstein, P., Celniker, S. E., Chervitz, S. A., Coates, D., Cravchik, A., Gabrielian, A., Galle, R. F., Gelbart, W. M., George, R. A., Goldstein, L. S. B., Gong, F., Guan, P., Harris, N. L., Hay, B. A., Hoskins, R. A., Li, J., Li, Z., Hynes, R. O., Jones, S. J. M., Kuehl, P. M., Lemaitre, B., Littleton, J. T., Morrison, D. K., Mungall, C., O'Farrell, P. H., Pickeral, O. K., Shue, C., Vosshall, L. B., Zhang, J., Zhao, Q., Zheng, X. H., Zhong, F., Zhong, W., Gibbs, R., Venter, J. C., Adams, M. D., & Lewis, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Celera Genomics, Rockville, MD, 20850 USA.
- GenetixXpress, 78 Pacific Road, Palm Beach, Sydney, Australia 2108.
- University of California, Berkeley (US)
- Harvard University (US)
- University of Pennsylvania (US)
- European Bioinformatics Institute (GB)
- Stanford University (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- National Institutes of Health (US)
- Lawrence Berkeley National Laboratory (US)
- Neomorphic, 2612 Eighth Street, Berkeley, CA 94710, USA.
- University of Leeds (GB)
- California Institute of Technology (US)
- BC Cancer Agency (CA)
- University of Maryland, Baltimore (US)
- Centre de Génétique Moléculaire, CNRS, 91198 Gif-sur-Yvette, France.
- Massachusetts Institute of Technology (US)
- Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.
- Columbia University (US)
- Baylor College of Medicine (US)
- ORCID
- Rubin, Gerald M.
- Yandell, Mark D.
- Wortman, Jennifer R.
- Nelson, Catherine R.
- Hariharan, Iswar K.
- Apweiler, Rolf
- Cherry, J. Michael
- Henikoff, Steven
- Ashburner, Michael
- Birney, Ewan
- Celniker, Susan E.
- Chervitz, Stephen A.
- Gabrielian, Andrei
- George, Reed A.
- Goldstein, Lawrence S. B.
- Guan, Ping
- Harris, Nomi L.
- Hay, Bruce A.
- Li, Jiayin
- Hynes, Richard O.
- Jones, S. J. M.
- Littleton, J. Troy
- Morrison, Deborah K.
- Mungall, Chris
- Vosshall, Leslie B.
- Zhang, Jiong
- Zhao, Qi
- Zhong, Fei
- Zhong, Wenyan
- Gibbs, Richard
- Venter, J. Craig
- Adams, Mark D.
- Lewis, Suzanna
- Venue
- Science
- Published
- 2000-03-24
- Volume
- 287
- Issue
- 5461
- Pages
- 2204-2215
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2754258
- OpenAlex
- W2106013076
- Cited by
- 1,698
- References
- 87
- Citations by year
- 2026: 19 · 2025: 26 · 2024: 18 · 2023: 24 · 2022: 30 · 2021: 29 · 2020: 37 · 2019: 33 · 2018: 36 · 2017: 34 · 2016: 34 · 2015: 38 · 2014: 34 · 2013: 45 · 2012: 55
- FWCI
- 75.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Human Genome Research Institute (P50HG000750, P4IHG00739, P50-HG00750)
- National Institute of General Medical Sciences (R01GM037193, R01GM060988)
- National Institute of Neurological Disorders and Stroke (R01NS040296)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- comparative genomics, eukaryotic genomes, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, gene family expansion, multidomain proteins, signaling pathways, orthologs, human disease genes, model organisms
- MeSH terms
- Animals, Cell Adhesion, Cell Cycle, Drosophila melanogaster, Biological Evolution, Fungal Proteins, Multigene Family, Genetics, Medical, Humans, Immunity, Neoplasms, Saccharomyces cerevisiae, Signal Transduction, Helminth Proteins, Genome, Caenorhabditis elegans, Apoptosis, Protein Structure, Tertiary, Insect Proteins, Genes, Duplicate, Proteome, Genetic Diseases, Inborn
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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