The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Novel properties of peptides derived from the sequence coded by exon 26A of human elastin
Abstract
The exon 26A is a rarely expressed human elastin exon that codes for a hydrophilic and charged amino acid sequence. The functional role of elastin containing this additional sequence is unknown. The present investigation was aimed to determine the effect of synthetic peptides derived from this exon on the vascular tone of rat thoracic aorta. On phenilephrine-preconstricted rat thoracic aortic rings the peptides LSPELREGD and REGD cause dose-dependent relaxation in the concentration range from 10(-9) to 10(-5) M. omega-nitro-L-arginine methyl ester, a known inhibitor of the NO synthase, highly inhibits, although to a different extent, the relaxation induced by these peptides. Removal of endothelium and blocking of ATP-sensitive potassium channels by glibenclamide significantly inhibited the vasorelaxant activity of LSPELREGD but not that of REGD, suggesting a different mechanism of action and possibly a different receptor.
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“When inserted into the final transcript, exon 26A produces an increase of 99 base pairs, which code for 33 amino acids (GADEGVRRSLSPELREGDPSSSQHLPSTPSSPR) in the tropoelastin protein sequence (Fig. 3) and alter its structural and biological properties [37, 64, 65].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [65]
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Cites
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Elastin as a biomaterial for tissue engineering
Daamen, W. F., Veerkamp, J. H., van Hest, J. C. M., & van Kuppevelt, T. H. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.025 · Cited by 528
Biomimetic Scaffolds for Tissue Engineering
Kim, T. G., Shin, H., & Lim, D. W. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201103083 · Cited by 459
Holst, J., Watson, S., Lord, M. S., Eamegdool, S. S., Bax, D. V., Nivison-Smith, L. B., Kondyurin, A., Ma, L., Oberhauser, A. F., Weiss, A. S., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1687 · Cited by 273
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Mithieux, S. M., Rasko, J. E. J., & Weiss, A. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.01.055 · Cited by 244
Metadata
- Authors
- Ostuni, A., Lograno, M. D., Gasbarro, A. R., Bisaccia, F., & Tamburro, A. M.
- Affiliations
- University of Basilicata (IT)
- University of Bari Aldo Moro (IT)
- ORCID
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 34
- Issue
- 2
- Pages
- 130-135
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W1967409427
- Cited by
- 21
- References
- 23
- Citations by year
- 2021: 1 · 2019: 1 · 2016: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Basilicata) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- elastin peptides, vasorelaxation, thoracic aorta, nitric oxide, nitric oxide synthase inhibition, ATP-sensitive potassium channels, glibenclamide, endothelium, peptide receptors
- MeSH terms
- Animals, Aorta, Dose-Response Relationship, Drug, Elastin, Enzyme Inhibitors, Exons, Glyburide, Humans, Hypoglycemic Agents, Lactose, Male, Models, Biological, Muscle, Smooth, Vascular, Peptides, Virulence Factors, Bordetella, Phenylephrine, Tolbutamide, Vasoconstrictor Agents, 4-Aminopyridine, Rats, Wistar, Nitroarginine, Potassium Channel Blockers, Rats, In Vitro Techniques
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- CoChat. (2026). Citation check: Novel properties of peptides derived from the sequence coded by exon 26A of human elastin. https://app.cochat.ai/papers/10.1016/s1357-2725(01)00115-7
- The paper
- Ostuni, A., Lograno, M. D., Gasbarro, A. R., Bisaccia, F., & Tamburro, A. M. (2002). Novel properties of peptides derived from the sequence coded by exon 26A of human elastin. The International Journal of Biochemistry & Cell Biology. https://doi.org/10.1016/s1357-2725(01)00115-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
