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A family of phytochelatin synthase genes from plant, fungal and animal species
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“According to this scheme, a substantially modified version of that proposed by Cobbett (4, see “Introduction”), AtPCS1 is considered to catalyze a dipeptidyltranspeptidation reaction in which the γ-Glu-Cys donor acylates the enzyme, concomitant with the release of Gly.”
From Mechanism of Heavy Metal Ion Activation of Phytochelatin (PC) Synthase (2000) · cites this paper as [4]
Citations
Cites
Phytoremediation of soil metals
Chaney, R. L., Malik, M., Li, Y. M., Brown, S. L., Brewer, E. P., Angle, J. S., & Baker, A. J. (1997) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(97)80004-3 · Cited by 1,254
AtPCS1, a phytochelatin synthase from Arabidopsis : Isolation and in vitro reconstitution
Vatamaniuk, O. K., Mari, S., Lu, Y.-P., & Rea, P. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7110 · Cited by 410
Cited by
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Palenik, B., Grimwood, J., Aerts, A., Rouzé, P., Salamov, A., Putnam, N., Dupont, C., Jorgensen, R., Derelle, E., Rombauts, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611046104 · Cited by 625
Mechanism of Heavy Metal Ion Activation of Phytochelatin (PC) Synthase
Vatamaniuk, O. K., Mari, S., Lu, Y.-P., & Rea, P. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002997200 · Cited by 390
Heavy Metal Phytoremediation from Aquatic Ecosystems with Special Reference to Macrophytes
Rai, P. K. (2009) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643380801910058 · Cited by 374
“PCs are a family of peptides with the general structure (γ -Glu-Cys) n-Gly, where n equals 2–11 (Cobett, 2000; Rauser, 1990), which are rapidly synthesized in response to toxic levels of heavy metals (Cobbett, 1999; Zenk, 1996).”
BackgroundLee, S., Moon, J. S., Ko, T.-S., Petros, D., Goldsbrough, P. B., & Korban, S. S. (2003) · PLANT PHYSIOLOGY · doi:10.1104/pp.014118 · Cited by 345
“These peptides are rapidly synthesized in response to toxic levels of heavy metals in all tested plants (Zenk, 1996; Cobbett, 1999).”
BackgroundThe functions of inter- and intracellular glutathione transport systems in plants.
Foyer, C., Theodoulou, F., & Delrot, S. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(01)02086-6 · Cited by 288
Wachter, A., Wolf, S., Steininger, H., Bogs, J., & Rausch, T. (2004) · The Plant Journal · doi:10.1111/j.1365-313x.2004.02269.x · Cited by 254
MACRONUTRIENT UTILIZATION BY PHOTOSYNTHETIC EUKARYOTES AND THE FABRIC OF INTERACTIONS.
Grossman, A., & Takahashi, H. (2001) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.52.1.163 · Cited by 214
“This heavy metal chelator is synthesized from GSH by phytochelatin synthase and consists of repetitions of theγ -glutamylcysteine dipeptide that terminates with a glycine (33, 34).”
BackgroundHeiss, S. (2003) · Journal of Experimental Botany · doi:10.1093/jxb/erg205 · Cited by 195
“…observation that sequence conservation in the putative catalytic N-terminal domain is much higher than in the more variable C-terminal domain (Cobbett, 1999; data not shown); for example, all analysed sequences displayed an N-terminal conserved motif with the consensus sequence…”
BackgroundMethodSelf-citationPomponi, M., Censi, V., Girolamo, V. D., Paolis, A. D., di Toppi, L. S., Aromolo, R., Costantino, P., & Cardarelli, M. (2005) · Planta · doi:10.1007/s00425-005-0073-3 · Cited by 199
“PCs were first identified in the yeast Schizosaccharomyces pombe and have been subsequently found in all plants, in some fungal species, in marine diatoms and in certain animals ( Cobbett 1999 ).”
BackgroundBiosynthetic regulation of phytochelatins, heavy metal-binding peptides
Hirata, K., Tsuji, N., & Miyamoto, K. (2005) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.100.593 · Cited by 164
Tsuji, N., Hirayanagi, N., Okada, M., Miyasaka, H., Hirata, K., Zenk, M. H., & Miyamoto, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00265-6 · Cited by 132
Transcript levels of AtMRPs after cadmium treatment: induction of AtMRP3
Bovet, L., Eggmann, T., Meylan-Bettex, M., POLIER, J., Kammer, P. M., Marín, E., Feller, U., & Martinoia, E. (2003) · Plant Cell & Environment · doi:10.1046/j.1365-3040.2003.00968.x · Cited by 118
Vatamaniuk, O. K., Mari, S., Lang, A., Chalasani, S. H., Demkiv, L. O., & Rea, P. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313142200 · Cited by 133
A Common Highly Conserved Cadmium Detoxification Mechanism from Bacteria to Humans
Prévéral, S., Gayet, L., Moldes, C., Hoffmann, J., Mounicou, S., Gruet, A., Reynaud, F., Łobiński, R., Verbavatz, J., Vavasseur, A., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808130200 · Cited by 111
Llamas, A., Ullrich, C., & Sanz, A. (2000) · Plant and Soil · doi:10.1023/a:1004753521646 · Cited by 106
Evolution of Abscisic Acid Signaling for Stress Responses to Toxic Metals and Metalloids
Hu, B., Deng, F., Chen, G. J., Chen, X., Gao, W., Long, L., Xia, J., & Chen, Z. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00909 · Cited by 125
“…in Plant Science | www.frontiersin.org 7 that GSH is synthesized through g-glutamylcysteine synthetase (GSH1 or g-ECS) and glutathione synthetase (GSH2), while PCs are polymerized from GSH by PCS (PCS1, PCS2) in Arabidopsis (Cobbett, 1999; Vatamaniuk et al., 1999; Cobbett, 2000).”
BackgroundVivarès, D., Arnoux, P., & Pignol, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505833102 · Cited by 94
He, Z., Li, J., Zhang, H., & Ma, M. (2004) · Plant Science · doi:10.1016/j.plantsci.2004.07.001 · Cited by 88
Liu, Z., Gu, C., Chen, F., Yang, D., Wu, K., Chen, S., Jiang, J., & Zhang, Z. (2011) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-011-9461-2 · Cited by 78
“metal chelators and heavy metal sequestrators are associated with the synthesis of the poly[γ-Glu-Cys]n-X polymers, referred to as phytochelatins (PCs) [5–7].”
BackgroundLi, Y.-J., Dhankher, O., Carreira, L., Balish, R. S., & Meagher, R. (2005) · Environmental Toxicology and Chemistry · doi:10.1897/04-340r.1 · Cited by 79
“mutation of the g-ECS coding region [55], is much more sen-”
BackgroundLiedschulte, V., Wachter, A., An, Z.-G., & Rausch, T. (2010) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2010.00510.x · Cited by 76
Brulle, F., Cocquerelle, C., Wamalah, A. N., Morgan, A. J., Kille, P., Alain Leprêtre, A., & Vandenbulcke, F. (2008) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2007.10.032 · Cited by 76
Brassicaceae (Cruciferae) Family, Plant Biotechnology, and Phytoremediation
Palmer, C. E., Warwick, S. I., & Keller, W. A. (2001) · International Journal of Phytoremediation · doi:10.1080/15226510108500059 · Cited by 80
“A body of evidence suggests the involvement of sulfur-rich peptides and small proteins in heavy metal tolerance and detoxification of xenobiotics (Steffen, 1990; Murphy et al., 1997; Cobbett, 1999).”
BackgroundLee, S., Petros, D., Moon, J. S., Ko, T.-S., Goldsbrough, P. B., & Korban, S. S. (2003) · Plant Physiology and Biochemistry · doi:10.1016/s0981-9428(03)00140-2 · Cited by 64
Tang, Z., Fan, F., Deng, S., & Wang, D. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110950 · Cited by 83
Picault, N., Cazalé, A., Beyly, A., Cuiné, S., Carrier, P., Luu, D., Forestier, C., & Peltier, G. (2006) · Biochimie · doi:10.1016/j.biochi.2006.04.016 · Cited by 66
Brodribb, T., & Hill, R. (2000) · Plant Physiology · doi:10.1104/pp.123.3.1021 · Cited by 65
Molins, H., Michelet, L., Lanquar, V., Agorio, A., Giraudat, J., Roach, T., Krieger‐Liszkay, A., & Thomine, S. (2012) · Plant Cell & Environment · doi:10.1111/pce.12016 · Cited by 56
“However, the search for Cd hypersensitive Arabidopsis mutants and plant genes that are able to confer Cd tolerance in yeast have both pointed to a major role of phytochelatins in plant cadmium tolerance (Clemens et al. 1999; Cobbett 1999; Ha et al. 1999; Vatamaniuk et al. 1999).”
BackgroundSun, Q., Wang, X., Ding, S.-M., & Yuan, X.-F. (2005) · Environmental Toxicology · doi:10.1002/tox.20095 · Cited by 55
Worms take the ‘phyto’ out of ‘phytochelatins’
Vatamaniuk, O. K., Bucher, E. A., Ward, J. T., & Rea, P. A. (2002) · Trends in biotechnology · doi:10.1016/s0167-7799(01)01873-x · Cited by 50
Tsuji, N., Nishikori, S., Iwabe, O., Matsumoto, S., Shiraki, K., Miyasaka, H., Takagi, M., Miyamoto, K., & Hirata, K. (2005) · Planta · doi:10.1007/s00425-005-1513-9 · Cited by 47
“In terms of the functional domain of PC synthase, a highly homologous N-terminal region has been found among eukaryotic PC synthases, which is expected to play an important role in catalysis ( Cobbett 1999 ).”
BackgroundInfluentialMolecular characterization of phytochelatin synthase expression in transgenic Arabidopsis
Lee, S., Moon, J. S., Domier, L. L., & Korban, S. S. (2002) · Plant Physiology and Biochemistry · doi:10.1016/s0981-9428(02)01430-4 · Cited by 47
“MTs are small Cys-rich proteins encoded by multigene families; while, PCs are enzymatically synthesized Cys-rich polypeptides that are likely ubiquitous in plants, and possibly present in animals [ 6 ].”
BackgroundCharacterization of the Phytochelatin Synthase of Schistosoma mansoni
Ray, D., & Williams, D. L. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001168 · Cited by 39
Response of Wild Type of Arabidopsis thaliana to Copper Stress
Wójcik, M., & Tukiendorf, A. (2003) · Biologia plantarum · doi:10.1023/a:1022314201466 · Cited by 40
Brulle, F., Lemière, S., Waterlot, C., Douay, F., & Vandenbulcke, F. (2011) · Science of the Total Environment · doi:10.1016/j.scitotenv.2011.08.040 · Cited by 36
“Numerous studies of plants and animals living in close contact with soils have been carried out to better understand the mechanisms of action of contaminants, the physiological changes, and themechanisms of detoxification and acclimation induced by metal stress (Cobbett, 1999; Cobbett and Goldsbrough, 2002; Cui et al.…”
BackgroundRole of Phytochelatins in Phytoremediation of Heavy Metals
Grill, E., Mishra, S., Srivastava, S., & Tripathi, R. D. (2007) · Springer eBooks · doi:10.1007/978-3-540-34793-4_5 · Cited by 34
Lee, S., & Kang, B. S. (2005) · Molecules and Cells · doi:10.1016/s1016-8478(23)13140-2 · Cited by 32
Su, H., Zou, T., Lin, R., Zheng, J., Jian, S., & Zhang, M. (2020) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2020.08.012 · Cited by 44
Kotrba, P., & Ruml, T. (2000) · Collection of Czechoslovak Chemical Communications · doi:10.1135/cccc20001205 · Cited by 27
Bano, A., Singh, K., Singh, S. P., & Sharma, P. (2023) · Stresses · doi:10.3390/stresses3040046 · Cited by 30
“PCS catalyzes the synthesis of PCs using reduced GSH and similar thiols as substrates [100].”
MethodSun, Q., Wang, X.-R., Ding, S., & Yuan, X.-F. (2005) · doi:10.1111/j.1744-7909.2005.00073.x · Cited by 25
Shukla, D., Trivedi, P. K., Nath, P., & Tuteja, N. K. (2016) · Wiley eBooks · doi:10.1002/9783527694570.ch12 · Cited by 26
Antioxidant defense gene analysis in Brassica oleracea and Trifolium repens exposed to Cd and/or Pb
Bernard, F., Dumez, S., Brulle, F., Lemière, S., Platel, A., Nesslany, F., Cuny, D., Deram, A., & Vandenbulcke, F. (2016) · Environmental science and pollution research international · doi:10.1007/s11356-015-5636-7 · Cited by 19
“…the mechanisms of action of contaminants, the physiological changes, the detoxification, and acclimation mechanisms induced by metallic stress (Cobbett 1999; Stone et al. 2001; Responsible editor: Philippe Garrigues Electronic supplementary material The online version of this article…”
BackgroundCong, M., Zhao, J., Lü, J., Ren, Z., & Wu, H. (2016) · Chinese Journal of Oceanology and Limnology · doi:10.1007/s00343-016-4382-0 · Cited by 18
Rapid Isolation of Monoclonal Antibodies. Monitoring Enzymes in the Phytochelatin Synthesis Pathway
Li, Y., Kandasamy, M. K., & Meagher, R. B. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.010413 · Cited by 19
Chhikara, S., Singh, Y., Long, S. L., Minocha, R., Musante, C., White, J. C., & Dhankher, O. P. (2024) · Plant Cell Reports · doi:10.1007/s00299-024-03351-3 · Cited by 13
“For instance, Arabidopsis mutants deficient in γ-ECS or phytochelatin synthase (PCS) exhibit heightened sensitivity to Cd exposure (Cobbett 1999; Howden et al. 1995a, b).”
Metal Tolerance in Plants: The Roles of Thiol‐Containing Peptides
Zhang, W., & Cai, Y. Z. (2004) · Wiley eBooks · doi:10.1002/047147844x.aw691 · Cited by 1
Kim, J. H., & Lee, S. (2007) · Journal of Plant Biology · doi:10.1007/bf03030633 · Cited by 7
Ghosh, I., Ghosh, M., & Mukherjee, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-55426-6_7 · Cited by 15
Bellini, E., Sorce, C., Andreucci, A., Vitelli, V., Saba, A., Li, M.-N., Varotto, C., & di Toppi, L. S. (2024) · Plant Biosystems · doi:10.1080/11263504.2024.2357302 · Cited by 6
“This enzyme is almost ubiquitous and constitutively expressed in plants, in other eukaryotic organisms, and even in some cyanobacteria (Cobbett 1999; Clemens and Peršoh 2009; Mackiewicz and Gagat 2014).”
Brulle, F. (2008) · doi:10.70675/04822478zd1aez4d4ez8042z1f14ede2a1df · Cited by 1
“En effet, depuis leur découverte chez la levure Schizosaccharomyces pombe (Grill et al., 1985), les phytochélatines ont été caractérisées chez la plupart des plantes chez qui elles ont été étudiées (Cobbett, 1999).”
Kethavath, S. N., & TJPRC (2017) · International Journal of Agricultural Science and Research · doi:10.24247/ijasraug201734
Santini, O. (2013) · doi:10.70675/61e2056dzcef2z492dz8283z30075341cdb8
“In addition sequences similar to PC synthase gene have been identified from the aquatic midge, Chironomus, and a species of earthworm (Brulle et al., 2008; Cobbett, 1999).”
Background
Metadata
- Authors
- Cobbett, C.
- Affiliations
- The University of Melbourne (AU)
- Corresponding author
- Cobbett, C
- ORCID
- Cobbett, C
- Venue
- Trends in Plant Science
- Publisher
- Elsevier BV
- Published
- 1999-09-01
- Volume
- 4
- Issue
- 9
- Pages
- 335-337
- ISSN
- 1360-1385 (ISSN-L)
- OpenAlex
- W1978877250
- Cited by
- 63
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2020: 3 · 2019: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 1 · 2012: 3
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Plant Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
- Physical Sciences › Environmental Science › Water Science and Technology › Heavy Metal Pollution Remediation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Keywords
- phytochelatin synthase, phytochelatins, heavy metal detoxification, phytoremediation, gene family, metal stress
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