Virus interactions with mucosal surfaces: alternative receptors, alternative pathways

Bergelson, Jeffrey M

doi:10.1016/s1369-5274(03)00097-3

Cited by 22Bacteriophages and microbial interactionsVirology and Viral DiseasesHIV Research and Treatment

Virus interactions with mucosal surfaces: alternative receptors, alternative pathways

Bergelson, Jeffrey M·2003·Current Opinion in Microbiology

DOI 10.1016/s1369-5274(03)00097-3

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Abstract

Viruses attach to specific receptors, but identified receptors are often absent from the epithelial surfaces where infections begin. Viruses can bind to alternative receptor molecules present on epithelial surfaces and they can enter hosts in ways that bypass mucosal barriers to infection. To understand how viruses cross the mucosa to initiate infection we need new information about the mechanisms of attachment and entry into cells, but we also need in vivo studies to define precisely where infection occurs.

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Cell-cell junctions act as a barrier to virus entry and dissemination into the airway submucosa.
“Cell-cell junctions act as a barrier to virus entry and dissemination into the airway submucosa.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [19]
Cell-cell junctions hinder viral access to receptors within the epithelial basolateral membrane, an important interaction and entry site for several viruses.
“They hinder viral access to receptors within the epithelial basolateral membrane, which is an important interaction and entry site for several viruses (18, 19).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [19]

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Authors: Bergelson, J. M.
Affiliations: Children's Hospital of Philadelphia (US)
Corresponding author: Bergelson, Jeffrey M
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2003-08
Volume: 6
Issue: 4
Pages: 386-391
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/s1369-5274(03)00097-3
OpenAlex: W1966983838
Cited by: 22
References: 48
Citations by year: 2026: 1 · 2024: 1 · 2021: 1 · 2019: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 1
FWCI: 0.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Cystic Fibrosis Foundation
American Heart Association
National Institutes of Health
Topics: Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: viral attachment, mucosal infection, viral entry, mucosal barrier, host cell receptors, viral pathogenesis
MeSH terms: Animals, Humans, Mucous Membrane, Receptors, Cell Surface, Virulence, Virus Diseases, Viruses

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Virus interactions with mucosal surfaces: alternative receptors, alternative pathways

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