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Cell sheet engineering
Open accessAbstract
We have developed ‘cell sheet engineering’ in order to avoid the limitations of tissue reconstruction using biodegradable scaffolds or single cell suspension injection. Our concept is tissue reconstruction, not from single cells, but from cell sheets. Cell sheets are prepared using temperature-responsive culture dishes. Temperature-responsive polymers are covalently grafted onto the dishes, allowing various types of cells to adhere and proliferate at 37°C. The cells spontaneously detach when the temperature is reduced below 32°C without the need for proteolytic enzymes. The confluent cells are noninvasively harvested as single, contiguous cell sheets with intact cell-cell junctions and deposited extracellular matrix (ECM). We have used these harvested cell sheets for various tissue reconstructions, including ocular surfaces, periodontal ligaments, cardiac patches, and bladder augmentation.
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Cited by
Modular tissue engineering: engineering biological tissues from the bottom up
Nichol, J. W., & Khademhosseini, A. (2009) · Soft Matter · doi:10.1039/b814285h · Cited by 567
Sasagawa, T., Shimizu, T., Sekiya, S., Haraguchi, Y., Yamato, M., Sawa, Y., & Okano, T. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.036 · Cited by 301
Self-citationElloumi‐Hannachi, I., Yamato, M., & Okano, T. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02185.x · Cited by 271
Self-citationCell Therapy: Types, Regulation, and Clinical Benefits
El-Kadiry, A. E.-H., Rafei, M., & Shammaa, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.756029 · Cited by 256
Engineering the cardiac tissue microenvironment
Ronan, G., Bahcecioglu, G., Aliyev, N., & Zorlutuna, P. (2024) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ad0ea7 · Cited by 4
Metadata
- Authors
- Yamato, M., & Okano, T.
- Venue
- Materials Today
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 7
- Issue
- 5
- Pages
- 42-47
- ISSN
- 1369-7021 (ISSN-L)
- OpenAlex
- W2041052342
- Cited by
- 470
- References
- 0
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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