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Cited by 142Tuberculosis Research and EpidemiologyIron Metabolism and DisordersInfectious Diseases and Tuberculosis

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Iron and Mycobacterium tuberculosis infection

Lounis, Nacer, Truffot-Pernot, Chantal, Grosset, Jacques, Gordeuk, Victor R., Boelaert, Johan R.·2001·Journal of Clinical Virology
DOI 10.1016/s1386-6532(00)00136-0
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Abstract

Background iron is known to play a role in the susceptibility to and outcome of several infections. In view of the increasing worldwide problem of tuberculosis, it may be important to ascertain whether this is also the case with this infection.Objectives (1) to review studies conducted in vitro, in experimental animals, and in humans that provide evidence that iron status may influence the occurrence and outcome of tuberculosis. (2) To perform an in vivo study in mice, examining the effect of iron loading on experimental infection caused by a virulent strain of Mycobacterium tuberculosis.Results we studied the effect of iron loading on the growth in spleen and lungs of a virulent strain of M. tuberculosis, injected i.v. in female Balb/C mice. At sacrifice on day 42 after the experimental infection, the iron-loaded mice presented a significantly enhanced multiplication of M. tuberculosis in both the spleen and the lungs, when compared to the mice without iron loading.Conclusion Most of the studies, including our experimental study in mice, tend to suggest that an excess of iron may enhance the growth of M. tuberculosis and worsen the outcome of human tuberculosis.

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Crossref · 10.1016/s1386-6532(00)00136-0

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Research works printed but not linked: 2

  1. Delanghe, 1998, Haptoglobin polymorphism, iron metabolism and mortality of human immunodeficiency virus infection, AIDS, 12, 1027, 10.1097/00002030-199809000-00010 · DOI · Paper page
  2. Strachan AS, (1929). Haemosiderosis and haemochromatosis in South African natives with a comment on the etiology of haemochromatosis, MD Thesis, University of Glasgow.

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Metadata

Authors
Lounis, N., Truffot-Pernot, C., Grosset, J., Gordeuk, V. R., & Boelaert, J. R.
Affiliations
  • Sorbonne Université (FR)
  • Howard University (US)
  • AZ Sint-Jan (BE)
Corresponding author
Boelaert, Johan R.
ORCID
Gordeuk, Victor R.
Venue
Journal of Clinical Virology
Publisher
Elsevier BV
Published
2001-02
Volume
20
Issue
3
Pages
123-126
ISSN
1386-6532 (ISSN-L)
DOI
10.1016/s1386-6532(00)00136-0
OpenAlex
W2030633873
Cited by
142
References
18
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 11
FWCI
3.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Clinical Virology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (5UH1-HL-03679-02, UH1HL003679)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Keywords
iron status, Mycobacterium tuberculosis, tuberculosis, iron overload, bacterial growth, spleen, lung, host susceptibility to infection
MeSH terms
Animals, Disease Susceptibility, Female, Ferric Compounds, Haptoglobins, Humans, Iron, Lung, Macrophages, Mice, Inbred BALB C, Mycobacterium tuberculosis, Polysaccharides, Spleen, Tuberculosis, HIV Infections, Iron Overload, Mice

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