The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Iron and Mycobacterium tuberculosis infection
Abstract
Background iron is known to play a role in the susceptibility to and outcome of several infections. In view of the increasing worldwide problem of tuberculosis, it may be important to ascertain whether this is also the case with this infection.Objectives (1) to review studies conducted in vitro, in experimental animals, and in humans that provide evidence that iron status may influence the occurrence and outcome of tuberculosis. (2) To perform an in vivo study in mice, examining the effect of iron loading on experimental infection caused by a virulent strain of Mycobacterium tuberculosis.Results we studied the effect of iron loading on the growth in spleen and lungs of a virulent strain of M. tuberculosis, injected i.v. in female Balb/C mice. At sacrifice on day 42 after the experimental infection, the iron-loaded mice presented a significantly enhanced multiplication of M. tuberculosis in both the spleen and the lungs, when compared to the mice without iron loading.Conclusion Most of the studies, including our experimental study in mice, tend to suggest that an excess of iron may enhance the growth of M. tuberculosis and worsen the outcome of human tuberculosis.
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“It is well-established that increased availability of iron promotes the growth of M. tuberculosis and exacerbates TB (163–166).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [164]
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Macrophage defense mechanisms against intracellular bacteria
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Metadata
- Authors
- Lounis, N., Truffot-Pernot, C., Grosset, J., Gordeuk, V. R., & Boelaert, J. R.
- Affiliations
- Sorbonne Université (FR)
- Howard University (US)
- AZ Sint-Jan (BE)
- Corresponding author
- Boelaert, Johan R.
- ORCID
- Gordeuk, Victor R.
- Venue
- Journal of Clinical Virology
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 20
- Issue
- 3
- Pages
- 123-126
- ISSN
- 1386-6532 (ISSN-L)
- OpenAlex
- W2030633873
- Cited by
- 142
- References
- 18
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 11
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Virology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (5UH1-HL-03679-02, UH1HL003679)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- iron status, Mycobacterium tuberculosis, tuberculosis, iron overload, bacterial growth, spleen, lung, host susceptibility to infection
- MeSH terms
- Animals, Disease Susceptibility, Female, Ferric Compounds, Haptoglobins, Humans, Iron, Lung, Macrophages, Mice, Inbred BALB C, Mycobacterium tuberculosis, Polysaccharides, Spleen, Tuberculosis, HIV Infections, Iron Overload, Mice
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