The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Circulating Cardiac Autoantibodies in Dilated Cardiomyopathy and Myocarditis: Pathogenetic and Clinical Significance
Abstract
Dilated cardiomyopathy (DCM) is a relevant cause of heart failure and a common indication for heart transplantation. It may be idiopathic, familial/genetic, viral, autoimmune or immune-mediated associated with a viral infection. Myocarditis is an inflammatory disease of the myocardium; it may be idiopathic, infectious or autoimmune and may heal or lead to DCM. Thus, in a patient subset, myocarditis and DCM are thought to represent the acute and chronic stages of an organ-specific autoimmune disease of the myocardium. In keeping with this hypothesis, autoimmune features in patients with myocarditis/DCM include: familial aggregation; a weak association with HLA-DR4; abnormal expression of HLA class II on cardiac endothelium on endomyocardial biopsy; and detection of organ- and disease-specific cardiac autoantibodies of the IgG class in the sera of affected patients and symptom-free relatives. The cardiac autoantibodies detected by immunofluorescence are directed against multiple antigens. Two of these, first identified using immunoblotting and confirmed by ELISA, are the atrial-specific α- and the ventricular and skeletal muscle β-heavy chain isoform. The α-myosin isoform fulfils the expected criteria for organ-specific autoimmunity, in that immunization with cardiac, but not skeletal myosin reproduces, in susceptible mouse strains, the human disease phenotype of myocarditis/DCM; in addition, α-myosin is entirely cardiac-specific. Additional antigenic targets of heart-reactive autoantibodies include unknown sarcolemmal proteins, mitochondrial enzymes, β-adrenergic and muscarinic receptors. For some of these antibodies, there is in vitro evidence for a functional role. The organ-specific cardiac autoantibodies detected by immunofluorescence in symptom-free relatives were associated with echocardiographic features suggestive of early disease. Mid-term follow-up suggests that these antibodies are predictive markers of progression to DCM among symptom-free relatives with or without abnormal echocardiographic findings.
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Cites
A Clinical Trial of Immunosuppressive Therapy for Myocarditis
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Cited by
Eriksson, U., Ricci, R., Hunziker, L., Kurrer, M. O., Oudit, G. Y., Watts, T. H., Sonderegger, I., Bachmaier, K., Kopf, M., & Penninger, J. M. (2003) · Nature Medicine · doi:10.1038/nm960 · Cited by 405
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Usefulness of Immunosuppression for Giant Cell Myocarditis
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Luik, A., Radzewitz, A., Kieser, M., Walter, M., Bramlage, P., Hörmann, P., Schmidt, K., Horn, N., Brinkmeier-Theofanopoulou, M., Kunzmann, K., et al. (2015) · Circulation · doi:10.1161/circulationaha.115.016871 · Cited by 275
Cardiac Autoimmunity: Myocarditis
Bracamonte-Baran, W., & Čiháková, D. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-57613-8_10 · Cited by 228
Metadata
- Authors
- Caforio, A. L. P., Mahon, N. J., Tona, F., & McKenna, W. J.
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-08-01
- Volume
- 4
- Issue
- 4
- Pages
- 411-417
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W1985235249
- Cited by
- 273
- References
- 47
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Caforio, A. L. P., Mahon, N. J., Tona, F., & McKenna, W. J. (2002). Circulating Cardiac Autoantibodies in Dilated Cardiomyopathy and Myocarditis: Pathogenetic and Clinical Significance. European Journal of Heart Failure. https://doi.org/10.1016/s1388-9842(02)00010-7
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