New therapeutic approaches for metastatic thyroid carcinoma
Abstract
Treatment of metastatic differentiated thyroid cancer (DTC) includes the use of radioiodine and suppressive thyroid hormone treatment. A third of patients with distant metastases (who have radioiodine uptake, are younger than 40 years, have small metastases, and have well differentiated thyroid tumour) can be cured with radioiodine treatment. For other patients, there are no effective treatment modalities. However, the recent availability of molecularly targeted treatments has led to changes in the treatment strategy for DTC in patients with distant metastases, especially in those who are resistant to radioiodine treatment.
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DePTC accounts for approximately 5-10% of patients with PTC, leads to resistance to traditional therapeutic strategies and worsens prognosis.
“DePTC, which accounts for approximately 5-10% of patients with PTC, leads to resistance to traditional therapeutic strategies and worsens prognosis [9, 10, 29].”
From Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells (2017) · cites this paper as [29]
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“It was also shown o impair the growth of the ATC cell line xenografts in nude ice [228].”
BackgroundShaik, S., Nucera, C., Inuzuka, H., Gao, D., Garnaas, M., Frechette, G. M., Harris, L. N., Wan, L., Fukushima, H., Husain, A., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112446 · Cited by 93 · see citing works
Antitumor effects of anlotinib in thyroid cancer
Ruan, X., Shi, X., Dong, Q., Yu, Y., Hou, X., Song, X., Wei, X., Chen, L., & Gao, M. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0558 · Cited by 91 · see citing works
Versari, A., Sollini, M., Frasoldati, A., Fraternali, A., Filice, A., Froio, A., Asti, M., Fioroni, F., Cremonini, N., Putzer, D., et al. (2013) · Thyroid · doi:10.1089/thy.2013.0225 · Cited by 91 · see citing works
“In addition, when radioiodine treatment is not effective, disease control becomes more difficult (1,2).”
Standard and Emerging Therapies for Metastatic Differentiated Thyroid Cancer
O’Neill, C. J., Oucharek, J. J., Learoyd, D., & Sidhu, S. B. (2010) · The Oncologist · doi:10.1634/theoncologist.2009-0190 · Cited by 74 · see citing works
Contemporary management of papillary carcinoma of the thyroid gland
Rosenbaum, M. A., & McHenry, C. R. (2009) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.9.3.317 · Cited by 73 · see citing works
Boufraqech, M., Kłubo-Gwieździńska, J., & Kebebew, E. (2016) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2016.10.001 · Cited by 71 · see citing works
“Although the majority of PTC cases have excellent prognoses and responses to therapy, 10– 15% of patients show signs of disease recurrence during follow up, which is associated with shorter overall survival [11].”
BackgroundPazopanib Enhances Paclitaxel-Induced Mitotic Catastrophe in Anaplastic Thyroid Cancer
Isham, C. R., Bossou, A. R., Negron, V. C., Fisher, K. E., Kumar, R., Marlow, L. A., Lingle, W. L., Smallridge, R. C., Sherman, E. J., Suman, V. J., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004358 · Cited by 69 · see citing works
“In particular, Sorrentino et al. reported aurora B overexpression in ATC relative to DTC and additionally found in vivo antitumor effects resulting from antisense aurora B treatment (24).”
BackgroundInfluentialMolecular Targeted Therapies of Aggressive Thyroid Cancer
Ferrari, S. M., Fallahi, P., Politti, U., Materazzi, G., Baldini, E., Ulisse, S., Miccoli, P., & Antonelli, A. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00176 · Cited by 68 · see citing works
“Approximately one-third of cancerrelated deaths are associated with neck lesions alone (20).”
BackgroundSpinal metastasis in thyroid cancer
Ramadan, S., Ugas, M. A., Berwick, R., Notay, M., Cho, H., Jerjes, W., & Giannoudis, P. V. (2012) · Head & Neck Oncology · doi:10.1186/1758-3284-4-39 · Cited by 66 · see citing works
“However, this cannot entirely explain the upward trend [8-10].”
BackgroundThyroid computed tomography imaging: pictorial review of variable pathologies
Saeedan, M. B., Aljohani, I. M., Khushaim, A., Bukhari, S. Q., & Elnaas, S. T. (2016) · Insights into Imaging · doi:10.1007/s13244-016-0506-5 · Cited by 65 · see citing works
Nipp, M., Elsner, M., Balluff, B., Meding, S., Sarioglu, H., Ueffing, M., Rauser, S., Unger, K., Höfler, H., Walch, A. K., et al. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0815-6 · Cited by 63 · see citing works
New therapies for dedifferentiated papillary thyroid cancer
Fallahi, P., Mazzi, V., Vita, R., Ferrari, S., Materazzi, G., Galleri, D., Benvenga, S., Miccoli, P., & Antonelli, A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16036153 · Cited by 58 · see citing works
“about one third of cancer-related deaths are associated with the presence of neck lesions alone [9].”
BackgroundTargeting RET for thyroid cancer therapy
Lanzi, C., Cassinelli, G., Nicolini, V., & Zunino, F. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.10.033 · Cited by 60 · see citing works
Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives (Review)
Cao, Z., Gao, Q., Fu, M., Ni, N., Pei, Y., & Ou, W. (2018) · Oncology Letters · doi:10.3892/ol.2018.9856 · Cited by 57 · see citing works
Nontoxic Diffuse and Nodular Goiter and Thyroid Neoplasia
Schlumberger, M.-J., Filetti, S., & HAY, I. D. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00014-6 · Cited by 56 · see citing works
Self-citationIten, F., Müller-Stich, B. P., Schindler, C., Rasch, H. F., Rochlitz, C. F., Oertli, D., Maëcke, H. R., Müller‐Brand, J., & Walter, M. A. (2009) · Cancer · doi:10.1002/cncr.24272 · Cited by 56 · see citing works
“However, no therapy is established in case of dedifferentiation,(3) and the median survival is only about 3 years after loss of iodine avidity.(2) Treatment with carboplatin, cisplatin, doxorubicin, epirubicin, or combined regimes has shown only rare responses with life-threatening toxicity or even drug-related death,…”
BackgroundBroecker‐Preuss, M., Müller, S. P., Britten, M. W., Worm, K., Schmid, K. W., Mann, K., & Führer, D. (2015) · BMC Cancer · doi:10.1186/s12885-015-1186-0 · Cited by 56 · see citing works
“In contrast, 10 to 15% of patients initially diagnosed with differentiated carcinomas experience recurrent disease [1,4,5].”
BackgroundImaging for staging and management of thyroid cancer
King, A. D. (2008) · Cancer Imaging · doi:10.1102/1470-7330.2008.0007 · Cited by 54 · see citing works
Piccardo, A., Trimboli, P., Foppiani, L., Treglia, G., Ferrarazzo, G., Massollo, M., Bottoni, G., & Giovanella, L. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09491-2 · Cited by 52 · see citing works
Gunda, V., Bucur, O., Varnau, J., Borre, P. V., Bernasconi, M. J., Khosravi‐Far, R., & Parangi, S. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.78 · Cited by 51 · see citing works
“However, a subset of patients with anaplastic thyroid cancer (ATC) present with large invasive tumors and/or metastases, do not respond to any chemotherapeutic regimen and often die within months.(2) New data are emerging on the genetic or epigenetic changes, which seem to contribute to such dramatic worsening of the…”
BackgroundSalvatori, M., Biondi, B., & Rufini, V. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0066 · Cited by 51 · see citing works
Nucera, C., Goldfarb, M. R., Hodin, R. A., & Parangi, S. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.01.003 · Cited by 50 · see citing works
“Subsequent follow-up consists of yearly clinical exams, neck ultrasonography, and serum Tg level [55].”
BackgroundPiscazzi, A., Costantino, E., Maddalena, F., Natalicchio, M. I., Gerardi, A. M. T., Antonetti, R., Cignarelli, M., & Landriscina, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3269 · Cited by 49 · see citing works
“The other two thirds of patients are deemed refractory to radioiodine therapy, and among them, the rate of progression is extremely variable (1).”
BackgroundThe BRAFV600E mutation: what is it really orchestrating in thyroid cancer?
Nucera, C., Lawler, J., Hodin, R. A., & Parangi, S. (2010) · Oncotarget · doi:10.18632/oncotarget.210 · Cited by 48 · see citing works
“Surgical treatment, thyroid suppressive therapy and radioiodine treatment in patients at high risk for recurrence is standard [2].”
BackgroundLapa, C., Werner, R. A., Schmid, J.-S., Papp, L., Zsótér, N., Biko, J., Reiners, C., Herrmann, K., Buck, A. K., & Bundschuh, R. A. (2014) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2014.12.006 · Cited by 46 · see citing works
“Whereas standard treatment including surgery and radioiodine is very effective and leads to survival times of more than 40 years [2], no sufficient therapy is established in case of dedifferentiationwhen local treatment is not feasible anymore due to the extension of the disease [3].”
BackgroundMicroRNA Expression Profiles in the Management of Papillary Thyroid Cancer
Lee, J. C., Gundara, J. S., Glover, A. R., Serpell, J. W., & Sidhu, S. B. (2014) · The Oncologist · doi:10.1634/theoncologist.2014-0135 · Cited by 45 · see citing works
Perspectives for Improved and More Accurate Classification of Thyroid Epithelial Tumors
Eszlinger, M., Krohn, K., Hauptmann, S., Dralle, H., Giordano, T. J., & Paschke, R. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0201 · Cited by 42 · see citing works
“Already there are a number of different new molecular targeted drugs in clinical trials for thyroid cancer (57, 116).”
BackgroundMulti-targeted approach in the treatment of thyroid cancer
Chen, H. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s3062 · Cited by 40 · see citing works
Riwaldt, S., Bauer, J. W., Pietsch, J., Braun, M., Segerer, J., Schwarzwälder, A., Corydon, T. J., Infanger, M., & Grimm, D. G. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226108 · Cited by 40 · see citing works
“have a significant toxicity and show only transient and limited response rates [5].”
BackgroundGEMOX regimen in the treatment of metastatic differentiated refractory thyroid carcinoma
Spano, J., Vano, Y.-A., Vignot, S., Rouge, T. D. L. M., Hassani, L., Mouawad, R., Ménégaux, F., Khayat, D., & Leenhardt, L. (2011) · Medical Oncology · doi:10.1007/s12032-011-0070-2 · Cited by 39 · see citing works
“Still, there is a lack of data and trials concerning the most recent drugs such as taxanes, gemcitabine, oxaliplatin, topoisomerase inhibitors, alone or in combination [5, 7].”
BackgroundThyroid Cancer: Current Molecular Perspectives
Giusti, F., Falchetti, A., Franceschelli, F., Marini, F., Tanini, A., & Brandi, M. L. (2010) · Journal of Oncology · doi:10.1155/2010/351679 · Cited by 39 · see citing works
“BAY 43-9006 has been tested on several types of human carcinomas including TCa, and the preliminary results showed a minimal or partial response in some patients [167].”
Molecular genetics of papillary thyroid carcinoma: great expectations...
Trovisco, V., Soares, P., Preto, A., Castro, P., Máximo, V., & Sobrinho-Simões, M. A. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000500002 · Cited by 37 · see citing works
Sunitinib inhibits papillary thyroid carcinoma with RET/PTC rearrangement but not BRAF mutation
Jeong, W., Mo, J., Park, M. W., Choi, I. J., An, S.-Y., Jeon, E.-H., & Ahn, S. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.12.5.16303 · Cited by 37 · see citing works
“com Cancer Biology & Therapy 461 disease remains in 10–15% of the patients.(3) Ten-year survival rate drops to 25% when distant metastasis is detected.”
BackgroundShowalter, T. N., Siegel, B. A., Moley, J. F., Baranski, T., & Grigsby, P. W. (2008) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2008.0501 · Cited by 37 · see citing works
Yu, X.-M., Jaskula‐Sztul, R., Georgen, M. R., Aburjania, Z., Somnay, Y. R., LEVERSON, G. E., Sippel, R. S., Lloyd, R. V., Johnson, B. P., & Chen, H. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1749 · Cited by 37 · see citing works
“Despite the excellent prognosis for most of the DTC patients, those with high-risk profiles may still suffer from disease progression, including tumor recurrence andmetastases, which poses a major challenge to the current treatment modality (14).”
BackgroundInfluentialSelective use of vandetanib in the treatment of thyroid cancer
Antonelli, A., Fallahi, P., Bari, F. D., Ferrari, S. M., Spisni, R., Materazzi, G., Miccoli, P., & Benvenga, S. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s72495 · Cited by 36 · see citing works
“However, 5% of patients have distant metastasis at the diagnosis or recurrent disease that cannot be treated with surgery and/or are resistant to RAI (because during progression, tumor cells lose RAI uptake ability).(66,67) For patients with metastatic disease, the NCCN Thyroid Carcinoma Panel recommends individualize…”
Enríquez, J. E., Muñoz-Montero, S. A., Imaz-Rosshandler, I., Huerta-Verde, A. J., Mejía, C., & Lemus, E. H. (2015) · BMC Genomics · doi:10.1186/s12864-015-1372-0 · Cited by 35 · see citing works
“On the other hand, ATC is an undifferentiated thyroid cancer, usually diagnosed at an advanced stage and thus not responding to chemotherapy; therefore frequently leading to a fatal prognosis [1].”
BackgroundWang, R., Yajun, C., Su, D., Gong, B., He, X., Zhou, X., Pang, Z., Cheng, L., Chen, Y., & Yao, Z. (2017) · Journal of Cancer · doi:10.7150/jca.21148 · Cited by 34 · see citing works
Update on Recent Developments in the Therapy of Differentiated Thyroid Cancer
Middendorp, M., & Grünwald, F. (2010) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2009.10.006 · Cited by 34 · see citing works
Ke, Y., & Xiang, C. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s187240 · Cited by 32 · see citing works
“Dedifferentiated tumors are more aggressive and had a worse outcome.(6,7) Currently, novel molecular targeting agents are gradually changing the natural history of traditional systemic chemotherapies of RAI-refractory thyroid cancer, which have showed improved progression-free survival in patients while the focus abla…”
BackgroundTsimberidou, A. M., Vaklavas, C., Wen, S., Hong, D. S., Wheler, J. J., Ng, C. S., Naing, A., Tse, S., Busaidy, N. L., Markman, M. M., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0743 · Cited by 32 · see citing works
“the disease is advanced or rapidly progressive (6).”
BackgroundInfluentialThyroid Cancer in Young Adults
Ying, A. K., Huh, W. W., Bottomley, S. J., Evans, D. B., & Waguespack, S. G. (2009) · Seminars in Oncology · doi:10.1053/j.seminoncol.2009.03.009 · Cited by 31 · see citing works
Coding Molecular Determinants of Thyroid Cancer Development and Progression
Valvo, V., & Nucera, C. (2018) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2018.10.003 · Cited by 31 · see citing works
Broecker‐Preuss, M., Becher-Boveleth, N., Müller, S. P., & Mann, K. (2016) · Cancer Cell International · doi:10.1186/s12935-016-0303-8 · Cited by 30 · see citing works
“However, in 10–15 % of patients initially diagnosed with differentiated carcinomas the tumor behaves aggressively and there is currently no effective treatment strategy since tumor dedifferentiation is accompanied by a reduction in radioiodine uptake and storage [4–6].”
BackgroundChen, H., Luo, D., Zhang, L., Lin, X., Luo, Q., Yi, H., Wang, J., Yan, X., Li, B., Chen, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17398 · Cited by 29 · see citing works
“DePTC, which accounts for approximately 5-10% of patients with PTC, leads to resistance to traditional therapeutic strategies and worsens prognosis [9, 10, 29].”
BackgroundMechanisms of apoptosis in irradiated and sunitinib-treated follicular thyroid cancer cells
Grosse, J., Warnke, E., Wehland, M., Pietsch, J., Pöhl, F., Wise, P. M., Magnusson, N. E., Eilles, C., & Grimm, D. G. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0937-0 · Cited by 29 · see citing works
“Because cytostatic chemotherapeutic substances are associated with significant toxicity and show only transient and limited response rates of 0–22 % [33],”
Refractory thyroid carcinoma: which systemic treatment to use?
Faugeras, L., Pirson, A., Donckier, J. E., Michel, L. A., Lemaire, J., Vandervorst, S., & D'Hondt, L. A. (2018) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834017752853 · Cited by 27 · see citing works
Molecular Targeted Therapies for Patients with Refractory Thyroid Cancer
Chougnet, C., Brassard, M., Leboulleux, S., Baudin, É., & Schlumberger, M. J. (2010) · Clinical Oncology · doi:10.1016/j.clon.2010.04.008 · Cited by 26 · see citing works
“In 80% of papillary thyroid carcinomas, activating mutations have been found in genes encoding signalling molecules of the mitogen-activated protein (MAP) kinase pathway, and are believed to be the initiating event [5,6,24,25].”
BackgroundSelf-citationSurgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules
Mekel, M., Nucera, C., Hodin, R. A., & Parangi, S. (2010) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2009.08.029 · Cited by 25 · see citing works
A three-microRNA panel in serum as novel biomarker for papillary thyroid carcinoma diagnosis
Zou, X., Gao, F., Wang, Z., Zhang, H., Liu, Q., Jiang, L., Xin Min, Z. H. O. U., & Zhu, W. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001107 · Cited by 23 · see citing works
“Although most cases have a favorable prognosis after timely treatment, there is still a considerable proportion of patients with high-grade malignancy and poor overall survival.([19]) A previous study has validated the stable existence of miRNAs in blood circulation.”
BackgroundReferral bias in thyroid cancer surgery: Direction and magnitude
Machens, A., Hauptmann, S., & Dralle, H. (2007) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2007.07.006 · Cited by 23 · see citing works
Targeted therapies for advanced thyroid cancer
Puxeddu, E., Romagnoli, S., & Dottorini, M. E. (2010) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328340cf94 · Cited by 22 · see citing works
Spinal cord compression as initial presentation of metastatic occult follicular thyroid carcinoma
Khan, M. N., Sharfuzzaman, A., & Mostafa, M. G. (2014) · Journal of Neurosciences in Rural Practice · doi:10.4103/0976-3147.131661 · Cited by 21 · see citing works
“Solitary distant metastases of follicular thyroid carcinoma are very rarely amenable to complete resection and thus some local procedures to delay tumor progression and for symptom palliation are used, such as embolization, radio frequency, or cement injection and treatment with bisphosphonates.[24] However, both the…”
Zanotti‐Fregonara, P., Rubello, D., & Hindié, E. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.054163 · Cited by 20 · see citing works
“In these patients, new molecular targeted treatments may provide hope (13).”
BackgroundMohamed, A. F., González, J. M., & Fairchild, A. O. (2015) · Journal of Thyroid Research · doi:10.1155/2015/438235 · Cited by 20 · see citing works
“The focus is now on molecular targets like tyrosine kinase inhibitors (TKIs) and angiogenesis pathways [9, 14, 15].”
BackgroundInvestigational Therapies for Metastatic Thyroid Carcinoma
Tuttle, R. M., & Leboeuf, R. (2007) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2007.0055 · Cited by 20 · see citing works
“Because clinical trials have a small but definite risk of morbidity and mortality, proper patient selection is critical.(7) Furthermore, because trial outcomes are usually based on disease stabilization rather than dramatic reduction in tumor size, patients must have structurally progressive, measurable disease before…”
BackgroundInfluentialRadioiodine Imaging and Treatment in Thyroid Disorders
Griggs, W.-S., & Divgi, C. R. (2008) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2008.03.008 · Cited by 19 · see citing works
Standard and Emerging Therapeutic Approaches for Thyroid Malignancies
Brown, R. L. (2008) · Seminars in Oncology · doi:10.1053/j.seminoncol.2008.03.011 · Cited by 19 · see citing works
Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells
Broecker‐Preuss, M., Viehof, J., Jastrow, H., Becher-Boveleth, N., Führer, D., & Mann, K. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0186-x · Cited by 18 · see citing works
“due to their ability to take up radioiodine [5, 6].”
BackgroundImpact of Sunitinib on Human Thyroid Cancer Cells
Grosse, J., Warnke, E., Pöhl, F., Magnusson, N. E., Wehland, M., Infanger, M., Eilles, C., & Grimm, D. G. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350132 · Cited by 18 · see citing works
Wang, C., Diao, H., Ren, P., Wang, X., Wang, Y., & Zhao, W. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00640 · Cited by 17 · see citing works
“Although DTC is a tumor with a high degree of differentiation, disease recurrence or metastasis in DTC patients after surgery remains approximately 10–30% (10, 11).”
BackgroundReview: What Can Be Expected from Nuclear Medicine Tomorrow?
Barbet, J., Kraeber‐Bodéré, F., & Chatal, J. (2008) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2008.010-u · Cited by 17 · see citing works
Saha, S., Majumdar, R., Dighe, R. R., & Chakravarty, A. R. (2010) · Metallomics · doi:10.1039/c0mt00028k · Cited by 17 · see citing works
Age disparities in referrals to specialist surgical care for papillary thyroid cancer
Machens, A., & Dralle, H. (2009) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2009.07.008 · Cited by 17 · see citing works
“In papillary thyroid cancer, the interference of thyroid-stimulating hormone (TSH) and anti-thyroglobulin antibodies with thyroglobulin serum concentrations can diminish the relevance of thyroglobulin as a tumor marker.(12)”
BackgroundDíez, J. J., Iglesias, P., Alonso, T., & Grande, E. (2014) · Endocrine · doi:10.1007/s12020-014-0356-1 · Cited by 15 · see citing works
“classical chemotherapeutic agents have demonstrated limited activity with no impact on survival [3] and their use is no longer recommended in international guidelines [4].”
Distant metastases of differentiated thyroid cancer: diagnosis, treatment and outcome.
Toubert, M., Hindié, E., Rampin, L., AL-NAHHAS, A. M., & Rubello, D. (2007) · PubMed · Cited by 15 · see citing works
Targeted molecular therapies in thyroid carcinoma
Romagnoli, S., Moretti, S., Voce, P., & Puxeddu, E. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000900002 · Cited by 13 · see citing works
“Typically, these patients are younger, have well differentiated tumors, high radioiodine uptake, small metastases, location in the lung, stable or slow progressive disease and low uptake of fluorodeoxyglucose on 18-FDG PET scan (7).”
BackgroundInfluentialLu-177 labelled peptide treatment for radioiodine refractory differentiated thyroid carcinoma
Elboğa, U., Özkaya, M., Sayıner, Z. A., & Celen, Y. Z. (2016) · BMJ Case Reports · doi:10.1136/bcr-2015-213627 · Cited by 12 · see citing works
Ersahin, D., Doddamane, I., & Cheng, D. (2011) · Cancers · doi:10.3390/cancers3043858 · Cited by 12 · see citing works
Kaldrymides, P., Kostoglou‐Athanassiou, I., Gkountouvas, A., Veniou, E., & Ziras, N. (2010) · Endocrine · doi:10.1007/s12020-009-9290-z · Cited by 11 · see citing works
“High expression levels of tyrosine kinase receptors for fibroblast growth factor, epidermal growth factor, and vascular endothelial growth factor have also been observed in thyroid cancer [ 23 ].”
BackgroundAtallah, V., Hocquelet, A., Cao, C. D., Zerdoud, S., de la Fouchardière, C., Bardet, S., Italiano, A., Dierick-Gallet, A., Leduc, N., Bonichon, F., et al. (2016) · Thyroid · doi:10.1089/thy.2015.0648 · Cited by 10 · see citing works
“In those patients in whom progressive disease has been documented, classical chemo-therapeutic agents have demonstrated limited effectiveness (2).”
Huang, T., Cheng, Y.-K., Chen, T.-W., Hsu, Y.-C., Liu, E., & Chen, H. (2017) · Endocrinology Diabetes and Metabolism Case Reports · doi:10.1530/edm-16-0100 · Cited by 10 · see citing works
“Doxorubicin is the most frequent chemotherapy agent, but only partial response rate of 22% can be achieved (14).”
Kinase inhibitors for refractory thyroid cancers
Schlumberger, M. J. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70226-6 · Cited by 10 · see citing works
Self-citationShi, P., Zhang, L., Shi, H., & Wu, Y. (2022) · Oncology Research and Treatment · doi:10.1159/000524489 · Cited by 9 · see citing works
Abuqbeitah, M., Demır, M., Kabasakal, L., Çavdar, İ., Uslu, L., Yeyin, N., Razavikhosroshahi, S., & Sönmezoğlu, K. (2018) · Nuclear Medicine Communications · doi:10.1097/mnm.0000000000000900 · Cited by 9 · see citing works
Targeted therapy in refractory thyroid cancer
Schlumberger, M. J. (2011) · European Journal of Cancer · doi:10.1016/s0959-8049(11)70190-3 · Cited by 9 · see citing works
Self-citationBroecker‐Preuss, M., Becher-Boveleth, N., Gall, S., Rehmann, K., Schenke, S., & Mann, K. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0251-8 · Cited by 9 · see citing works
“Patients with recurrent disease have different outcomes due to the degree of dedifferentiation of their tumour and due to its ability to take up radioiodine [26, 28].”
BackgroundEmerging Therapies in Sight for the Fight against Dedifferentiated Thyroid Cancer
Benvenga, S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2799 · Cited by 9 · see citing works
Prise en charge des cancers réfractaires de la thyroïde
Schlumberger, M. J. (2011) · Annales d Endocrinologie · doi:10.1016/j.ando.2011.03.020 · Cited by 8 · see citing works
Self-citationWu, Z., Cao, Y. Z., Jiang, X., Li, M., Wang, G., Yang, Y., & Lü, K. (2020) · Minerva Endocrinology · doi:10.23736/s0391-1977.18.02709-8 · Cited by 8 · see citing works
Zhang, W., Liu, D., Feng, C.-C., Zhou, C.-B., Zhan, C., Que, R., & Chen, L. (2014) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400124 · Cited by 7 · see citing works
“CT of the neck and chest and MRI of the spine, pelvis, and femurs can be useful to visualize metastatic foci (Baudin and Schlumberger, 2007).”
BackgroundRendl, G., Rettenbacher, L., Schweighofer-Zwink, G., Hehenwarter, L., & Pirich, C. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1111-8927 · Cited by 7 · see citing works
Positron Emission Tomography/Computed Tomography in Thyroid Cancer
Bal, C., Chakraborty, D., & Khan, D. (2022) · PET Clinics · doi:10.1016/j.cpet.2021.12.004 · Cited by 7 · see citing works
A protective factor against lymph node metastasis of papillary thyroid cancer: Female gender
Shi, P., Yang, D., Liu, Y., Zhao, Z., Song, J., Shi, H., Wu, Y., & Jing, S. (2022) · Auris Nasus Larynx · doi:10.1016/j.anl.2022.10.001 · Cited by 7 · see citing works
Novel approaches in the treatment of thyroid cancer
Brown, R. L., & Cohen, E. E. W. (2008) · Update on Cancer Therapeutics · doi:10.1016/j.uct.2008.01.002 · Cited by 7 · see citing works
Different CXCR4 Expression According to Various Histologic Subtype of Papillary Thyroid Carcinoma
Shin, D. Y., Kim, K. J., Ku, C. R., Lee, M. K., Jee, S. I., Chung, W. Y., & Lee, E. J. (2013) · Endocrine Pathology · doi:10.1007/s12022-013-9259-6 · Cited by 7 · see citing works
“However, 10–15 % of patients with DTC experience tumor recurrence and 5 % of them present with distant metastasis, leading to decreased 10-year survival rates of 49–68 and 25–42 %, respectively, in each case [5].”
BackgroundThe Association Between Lymph Node Metastasis and Molecular Markers in Differentiated Thyroid Cancer
Aydoğan, B. (2018) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2018.55 · Cited by 7 · see citing works
“Ten years survival rate decreases to 49-68% in node positive disease (6).”
Background
- Authors
- Baudin, E., & Schlumberger, M.
- Affiliations
- Institut Gustave Roussy (FR)
- ORCID
- Schlumberger, Martin
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 8
- Issue
- 2
- Pages
- 148-156
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2132185197
- Cited by
- 143
- References
- 77
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 6 · 2020: 6 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 11 · 2015: 13 · 2014: 11 · 2013: 7 · 2012: 8
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- metastatic thyroid cancer, differentiated thyroid cancer, radioiodine therapy, targeted therapy, radioiodine resistance, distant metastasis, treatment options
- MeSH terms
- Humans, Iodine Radioisotopes, Thyroid Neoplasms
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