Nosocomial infections in patients with cancer
Abstract
Nosocomial infections are those that become evident 48 h or more after a patient is admitted for treatment in a hospital or in another health-care setting. These infections cause substantial morbidity and mortality in patients who are immunosuppressed. Over the past few decades, understanding of host vulnerability has improved and more rigorous management and infection-control practices have been adopted for treating susceptible populations. Despite efforts, outbreaks continue to occur. In this Review, we outline current knowledge of the incidence and microbiology of various nosocomial infections in patients with cancer-a large, immunosuppressed population.
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Cancer patients have greater vulnerability to infection than people without cancer, owing to immune suppression from the malignancy and treatments such as chemotherapy or surgery.
“Patients with cancer are more susceptible to infection than individuals without cancer because of their systemic immunosuppressive state caused by the malignancy and anticancer treatments, such as chemotherapy or surgery.5, 6, 7, 8”
From Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China (2020) · cites this paper as [5]
SARS-CoV-2 infections in patients with cancer appear more likely to cause severe morbidity and mortality, owing in part to advanced age and immunosuppressive effects of malignancies and treatments.
“SARS-CoV-2 infections in patients with cancer appear more likely to cause severe morbidity and mortality, owing in part to these individuals' more advanced age and in part to the immunosuppressive effects of their malignancies and the drugs, radiation, and surgical procedures used to treat them (10–12).”
From Cancer Care During COVID-19 Era: The Quality of Life of Patients With Thyroid Malignancies (2020) · cites this paper as [11]
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References 99 · Cited by 318
- Authors
- Kamboj, M., & Sepkowitz, K. A.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Kamboj, Mini
- ORCID
- Kamboj, Mini
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 10
- Issue
- 6
- Pages
- 589-597
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2121135500
- Cited by
- 318
- References
- 99
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 11 · 2023: 32 · 2022: 33 · 2021: 49 · 2020: 112 · 2019: 8 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 3 · 2012: 8
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Keywords
- nosocomial infections, cancer patients, immunosuppression, infection control, infectious disease outbreaks, infection microbiology, infection incidence
- MeSH terms
- Cross Infection, Hospitals, Humans, Influenza, Human, Neoplasms, Respiratory Syncytial Virus Infections
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