The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Statins and breast cancer prognosis: evidence and opportunities
Open accessAbstract
SUMMARY Much preclinical and epidemiologic evidence supports anticancer effects of HMG-CoA reductase inhibitors (statins). Epidemiologic evidence does not support an association between statin use and reduced breast cancer incidence, but does support a protective effect of statins—particularly simvastatin—on breast cancer prognosis. We argue that the current evidence base is sufficient to justify a clinical trial of breast cancer adjuvant therapy with statins. We advocate for such a trial to be initiated without delay. If a protective effect of statins on breast cancer recurrence is supported by trial evidence, then the indications for a safe, well-tolerated, and in expensive treatment can be expanded to improve outcomes for breast cancer survivors. We discuss several design opportunities—including candidate predictive biomarkers of statin safety and efficacy—and offer solutions to key challenges to enrolment, follow-up, and analysis of such a trial.
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Cites
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Statin Prescriptions and Breast Cancer Recurrence Risk: A Danish Nationwide Prospective Cohort Study
Ahern, T. P., Pedersen, L., Tarp, M., Cronin-Fenton, D. P., Garne, J. P., Silliman, R. A., Sorensen, H. T., & Lash, T. L. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr291 · Cited by 387
Self-citationTargeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial
Bjarnadottir, O., Romero, Q., Bendahl, P.-O., Jirström, K., Rydén, L., Loman, N., Uhlén, M., Johannesson, H., Rose, C., Grabau, D., et al. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2473-6 · Cited by 230
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LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19
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Metadata
- Authors
- Ahern, T. P., Lash, T. L., Damkier, P., Christiansen, P. M., & Cronin-Fenton, D. P.
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 15
- Issue
- 10
- Pages
- e461-e468
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2126720685
- Cited by
- 203
- References
- 12
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Ahern, T. P., Lash, T. L., Damkier, P., Christiansen, P. M., & Cronin-Fenton, D. P. (2014). Statins and breast cancer prognosis: evidence and opportunities. The Lancet Oncology. https://doi.org/10.1016/s1470-2045(14)70119-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
