The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Immunotherapy and targeted therapy combinations in metastatic breast cancer
Abstract
Immunotherapy is emerging as a new treatment modality in breast cancer. After long-standing use of endocrine therapy and targeted biological therapy, improved understanding of immune evasion by cancer cells and the discovery of selective immune checkpoint inhibitors have created novel opportunities for treatment. Single-drug therapies with monoclonal antibodies against programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) have shown little efficacy in patients with metastatic breast cancer, in part because of the low number of tumour-infiltrating lymphocytes in most breast cancers. There is growing interest in the development of combinations of immunotherapy and molecularly targeted therapies for metastatic breast cancer. In this Personal View, we review the available data and ongoing efforts to establish the safety and efficacy of immunotherapeutic approaches in combination with HER2-targeted therapy, inhibitors of cyclin-dependent kinases 4 and 6, angiogenesis inhibitors, poly(ADP-ribose) polymerase inhibitors, as well as chemotherapy and radiotherapy.
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Cites
Elements of cancer immunity and the cancer–immune set point
Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352
Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer
Schmid, P., Adams, S., Rugo, H. S., Schneeweiss, A., Barrios, C. H., Iwata, H., Diéras, V., Hegg, R., Im, S.-A., Shaw Wright, G., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1809615 · Cited by 4,350
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
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Palbociclib and letrozole in advanced breast cancer
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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
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CDK4/6 inhibition triggers anti-tumour immunity
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Self-citationCancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
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Self-citationPARP inhibitor upregulates PD-L1 expression and enhances cancer-associated immunosuppression
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Cited by
Prospects for combining immune checkpoint blockade with PARP inhibition
Li, A., Yi, M., Qin, S., Chu, Q., Luo, S., & Wu, K. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0784-8 · Cited by 143
“In the meanwhile, based on the hypothesis that patients with mutations in BRCA1/2 or other HR components are prone to possess higher mutation burden, multiple clinical trials are ongoing to explore the efficacy of combination therapy of PARPi and immune checkpoint inhibitors [56].”
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Atezolizumab for the treatment of breast cancer
Reddy, S. M., Carroll, E., & Nanda, R. (2020) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2020.1732211 · Cited by 94
Qiu, L., Kanski, B., Doerksen, S., Winkels, R., Schmitz, K. H., & Abdullah, S. (2021) · Extended Abstracts of the 2021 CHI Conference on Human Factors in Computing Systems · doi:10.1145/3411763.3451827 · Cited by 23
Metadata
- Authors
- Esteva, F. J., Hubbard-Lucey, V. M., Tang, J., & Pusztai, L.
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 20
- Issue
- 3
- Pages
- e175-e186
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2918171974
- Cited by
- 453
- References
- 14
- FWCI
- 23.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Esteva, F. J., Hubbard-Lucey, V. M., Tang, J., & Pusztai, L. (2019). Immunotherapy and targeted therapy combinations in metastatic breast cancer. The Lancet Oncology. https://doi.org/10.1016/s1470-2045(19)30026-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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