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IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation
Abstract
The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors "keep watch" for both endogenous and exogenous molecules that indicate tissue inquiry, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules.
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“IL-6 is a chemotactic and prosurvival factor for monocytes and neutrophils.83”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [83]
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Metadata
- Authors
- Kaplanski, G.
- Affiliations
- Inserm (FR)
- Corresponding author
- Kaplanski, G
- ORCID
- Kaplanski, G
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 24
- Issue
- 1
- Pages
- 25-29
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2091169302
- Cited by
- 811
- References
- 39
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 27 · 2023: 29 · 2022: 39 · 2021: 56 · 2020: 62 · 2019: 33 · 2018: 37 · 2017: 49 · 2016: 53 · 2015: 29 · 2014: 31 · 2013: 39 · 2012: 36
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- interleukin-6, neutrophil recruitment, monocyte recruitment, inflammation, Toll-like receptors, immune system evolution, innate immunity
- MeSH terms
- Animals, Cell Movement, Humans, Inflammation, Lymph Nodes, Models, Biological, Monocytes, Neutrophils, Signal Transduction, Interleukin-6, Apoptosis, Receptors, Interleukin-6, Mice
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