Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works

Role of CD47 as a Marker of Self on Red Blood Cells

Oldenborg, P., Zheleznyak, A., Fang, Y., Lagenaur, C. F., Gresham, H. D., & Lindberg, F. P. (2000) · Science · doi:10.1126/science.288.5473.2051 · Cited by 1,975 · see citing works

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536 · see citing works

Corpse clearance defines the meaning of cell death

Savill, J., & Fadok, V. A. (2000) · Nature · doi:10.1038/35037722 · Cited by 1,535 · see citing works

A receptor for phosphatidylserine-specific clearance of apoptotic cells

Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491 · see citing works

PECAM-1 is required for transendothelial migration of leukocytes.

Müller, W. A., Weigl, S. A., Deng, X., & Phillips, D. M. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.449 · Cited by 1,151 · see citing works

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

Savill, J., Dransfield, I., Hogg, N., & Haslett, C. (1990) · Nature · doi:10.1038/343170a0 · Cited by 846 · see citing works

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

Savill, J., Hogg, N., Ren, Y., & Haslett, C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116019 · Cited by 813 · see citing works

The biology of PECAM-1.

Newman, P. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119129 · Cited by 671 · see citing works

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

Reedquist, K. A., Ross, E. A., Koop, E. A., Wolthuis, R. M. F., Zwartkruis, F. J. T., van Kooyk, Y., Salmon, M., Buckley, C. D., & Bos, J. L. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.6.1151 · Cited by 415 · see citing works

CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.

Ren, Y., Silverstein, R. L., Allen, J., & Savill, J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.5.1857 · Cited by 389 · see citing works

A perfusion chamber developed to investigate platelet interaction in flowing blood with human vessel wall cells, their extracellular matrix, and purified components.

Sakaríassen, K. S., Aarts, P. A. M. M., de Groot, P. G., Houdijk, W. P. M., & Sixma, J. J. (1983) · PubMed · Cited by 366 · see citing works

Constitutive Death of Platelets Leading to Scavenger Receptor-mediated Phagocytosis

Brown, S. B., Clarke, M. C. H., Magowan, L., Sanderson, H. M., & Savill, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5987 · Cited by 168 · see citing works

Actin is cleaved during constitutive apoptosis

BROWN, S. B., BAILEY, K., & Savill, J. (1997) · Biochemical Journal · doi:10.1042/bj3230233 · Cited by 147 · see citing works

Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31

Newton, J. P., Buckley, C. D., Jones, E. Y., & Simmons, D. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20555 · Cited by 131 · see citing works

Differential association of cytoplasmic signalling molecules SHP‐1, SHP‐2, SHIP and phospholipase C‐γ1 with PECAM‐1/CD31

Pumphrey, N. J., Taylor, V., Freeman, S. D., Douglas, M. R., Bradfield, P. F., Young, S. P., Lord, J. M., Wakelam, M. J. O., Bird, I. N., Salmon, M., et al. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00446-9 · Cited by 102 · see citing works

Cross-talk between cell adhesion molecules regulates the migration velocity of neutrophils

Rainger, G. E., Buckley, C., Simmons, D. L., & Nash, G. B. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00155-2 · Cited by 90 · see citing works

Thrombospondin stimulates motility of human neutrophils.

Mansfield, P. J., Boxer, L. A., & Suchard, S. J. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.3077 · Cited by 86 · see citing works

Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration

Bird, I. N., Taylor, V., Newton, J. P., Spragg, J. H., Simmons, D. L., Salmon, M., & Buckley, C. D. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.12.1989 · Cited by 81 · see citing works

Biochemical Characterization of PECAM-1 (CD31 Antigen) on Human Platelets

Metzelaar, M. J., Korteweg, J., Sixma, J. J., & Nieuwenhuis, H. K. (1991) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646488 · Cited by 70 · see citing works

Mostly dead

Green, D. R., & Beere, H. M. (2001) · Nature · doi:10.1038/35084313 · Cited by 30 · see citing works

Regulation of cell death: the calcium–apoptosis link

Orrenius, S., Zhivotovsky, B., & Nicotera, P. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1150 · Cited by 3,013 · see citing works

A blast from the past: clearance of apoptotic cells regulates immune responses

Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574 · see citing works

Overview of cell death signaling pathways

Jin, Z., & El‐Deiry, W. S. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.2.1508 · Cited by 1,323 · see citing works

Apoptotic cell clearance: basic biology and therapeutic potential

Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223 · see citing works

Immunogenic and tolerogenic cell death

Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works

Apoptosis and Clearance of Apoptotic Cells

Nagata, S. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053010 · Cited by 1,107 · see citing works

The Cell Biology of Phagocytosis

Flannagan, R. S., Jaumouillé, V., & Grinstein, S. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132445 · Cited by 1,016 · see citing works

Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00422-7 · Cited by 967 · see citing works

Phagocytosis of apoptotic cells in homeostasis

Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959 · see citing works

Resolution of inflammation: a new therapeutic frontier

Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937 · see citing works

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

Walmsley, S. R., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R. S., Cramer, T., Sobolewski, A., Condliffe, A. M., Cowburn, A. S., Johnson, N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040624 · Cited by 891 · see citing works

The clearance of dead cells by efferocytosis

Boada-Romero, E., Martinez, J., Heckmann, B. L., & Green, D. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0232-1 · Cited by 893 · see citing works

IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation

Kaplanski, G. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(02)00013-3 · Cited by 811 · see citing works

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

Segawa, K., & Nagata, S. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.08.003 · Cited by 778 · see citing works

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

Ichimura, T., van Asseldonk, E. J. P., Humphreys, B. D., Gunaratnam, L., Duffield, J. S., & Bonventre, J. V. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34487 · Cited by 768 · see citing works

Engulfment of apoptotic cells: signals for a good meal

Ravichandran, K. S., & Lorenz, U. M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2214 · Cited by 634 · see citing works

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

Ravichandran, K. S. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.004 · Cited by 559 · see citing works

Clearance of Apoptotic Cells

Lauber, K., Blumenthal, S. G., Waibel, M., & Wesselborg, S. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00237-0 · Cited by 552 · see citing works

Phagocytosis: A Fundamental Process in Immunity

Rosales, C., & Uribe‐Querol, E. (2017) · BioMed Research International · doi:10.1155/2017/9042851 · Cited by 555 · see citing works

Clearance of apoptotic cells: implications in health and disease

Elliott, M. R., & Ravichandran, K. S. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004096 · Cited by 547 · see citing works

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

Ravichandran, K. S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101157 · Cited by 550 · see citing works

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

Hochreiter-Hufford, A., & Ravichandran, K. S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008748 · Cited by 503 · see citing works

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

Garg, A. D., Nowis, D., Gołąb, J., Vandenabeele, P., Krysko, D. V., & Agostinis, P. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.08.003 · Cited by 498 · see citing works

Clearance of apoptotic neutrophils and resolution of inflammation

Greenlee‐Wacker, M. C. (2016) · Immunological Reviews · doi:10.1111/imr.12453 · Cited by 478 · see citing works

Drugging the efferocytosis process: concepts and opportunities

Mehrotra, P., & Ravichandran, K. S. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00470-y · Cited by 459 · see citing works

Burying the Dead

Vandivier, R. W., Henson, P. M., & Douglas, I. S. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1673 · Cited by 450 · see citing works

Dying cells actively regulate adaptive immune responses

Yatim, N., Cullen, S., & Albert, M. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.9 · Cited by 442 · see citing works

Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment

Arur, S., Uche, U. E., Rezaul, K., Fong, M., Scranton, V., Cowan, A. E., Mohler, W., & Han, D. K. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00090-x · Cited by 434 · see citing works

Clearance of apoptotic cells by phagocytes

Erwig, L.-P., & Henson, P. M. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402184 · Cited by 422 · see citing works

Secondary necrosis: The natural outcome of the complete apoptotic program

Silva, M. T. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.10.046 · Cited by 412 · see citing works

The inflammatory macrophage: a story of Jekyll and Hyde

Duffield, J. S. (2002) · Clinical Science · doi:10.1042/cs1040027 · Cited by 441 · see citing works

Metchnikoff and the phagocytosis theory

Tauber, A. I. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1244 · Cited by 413 · see citing works

Signal Transduction Pathways Mediated by PECAM-1

Newman, P. J., & Newman, D. K. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000071347.69358.d9 · Cited by 399 · see citing works

Aminophospholipid Asymmetry: A Matter of Life and Death

Balasubramanian, K., & Schroit, A. J. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142459 · Cited by 396 · see citing works

Apoptotic cell removal in development and tissue homeostasis

Henson, P. M., & Hume, D. A. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.03.005 · Cited by 388 · see citing works

Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis

Padanilam, B. J. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00284.2002 · Cited by 369 · see citing works

Smoking Alters Alveolar Macrophage Recognition and Phagocytic Ability

Hodge, S. J., Hodge, G. L., Ahern, J., Jersmann, H. P. A., Holmes, M., & Reynolds, P. N. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0025oc · Cited by 357 · see citing works

Molecular mechanisms of late apoptotic/necrotic cell clearance

Poon, I. K. H., Hulett, M. D., & Parish, C. R. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.195 · Cited by 353 · see citing works

Neutrophil clearance: when the party is over, clean-up begins

Bratton, D. L., & Henson, P. M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.009 · Cited by 350 · see citing works

The Dynamics of Apoptotic Cell Clearance

Elliott, M. R., & Ravichandran, K. S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.029 · Cited by 314 · see citing works

Clearance of apoptotic and necrotic cells and its immunological consequences

Krysko, D. V., D’Herde, K., & Vandenabeele, P. (2006) · Apoptosis · doi:10.1007/s10495-006-9527-8 · Cited by 316 · see citing works

A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1

Muro, S., Wiewrodt, R. G., Thomas, A., Koniaris, L. S., Albelda, S. Μ., Muzykantov, V. R., & Koval, M. H. (2003) · Journal of Cell Science · doi:10.1242/jcs.00367 · Cited by 302 · see citing works

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Kourtzelis, I., Hajishengallis, G., & Chavakis, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00553 · Cited by 301 · see citing works

Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis

Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00086 · Cited by 300 · see citing works

The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?

Gregory, C. D., & Devitt, A. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01959.x · Cited by 285 · see citing works

Essential Role of the Apoptotic Cell Engulfment Genes draper and ced-6 in Programmed Axon Pruning during Drosophila Metamorphosis

Awasaki, T., Tatsumi, R., Takahashi, K., Arai, K., Nakanishi, Y., Ueda, R., & Ito, K. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.027 · Cited by 285 · see citing works

The final step in programmed cell death: phagocytes carry apoptotic cells to the grave

deCathelineau, A. M., & Henson, P. M. (2003) · Essays in Biochemistry · doi:10.1042/bse0390105 · Cited by 282 · see citing works

Annexin-1 and Peptide Derivatives Are Released by Apoptotic Cells and Stimulate Phagocytosis of Apoptotic Neutrophils by Macrophages

Scannell, M., Flanagan, M. B., deStefani, A., Wynne, K. J., Cagney, G., Godson, C., & MADERNA, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4595 · Cited by 282 · see citing works

A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies

Myhrinder, A. L., Hellqvist, E., Sidorova, E. V., Söderberg, A., Baxendale, H., Dahle, C., Willander, K., Tobin, G., Backman, E. J., Söderberg, O., et al. (2008) · Blood · doi:10.1182/blood-2007-11-125450 · Cited by 275 · see citing works

Cues for apoptotic cell engulfment: eat-me, don't eat-me and come-get-me signals

Grimsley‐Myers, C. M. (2003) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.10.004 · Cited by 248 · see citing works

Macrophages as mediators of tumor immunosurveillance

Jaiswal, S., Chao, M. P., Majeti, R., & Weissman, I. L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.04.001 · Cited by 241 · see citing works

Programmed cell removal: a new obstacle in the road to developing cancer

Chao, M. P., Majeti, R., & Weissman, I. L. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3171 · Cited by 246 · see citing works

PECAM-1: old friend, new partners

Ilan, N., & Madri, J. A. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00100-5 · Cited by 236 · see citing works

Recognition ligands on apoptotic cells: a perspective

Gardai, S. J., Bratton, D. L., Ogden, C. A., & Henson, P. M. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1005550 · Cited by 234 · see citing works

Recognition and clearance of apoptotic cells: a role for complement and pentraxins

Nauta, A. J., Daha, M. R., van Kooten, C., & Roos, A. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00030-9 · Cited by 231 · see citing works

The opsonin MFG-E8 is a ligand for the αvβ5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells

Akakura, S., Singh, S., Spataro, M., Akakura, R., Kim, J., Albert, M. L., & Birge, R. B. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.011 · Cited by 229 · see citing works

Camouflage strategies for therapeutic exosomes evasion from phagocytosis

Parada, N., Romero-Trujillo, A., Georges, N., & Alcayaga‐Miranda, F. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.01.001 · Cited by 237 · see citing works

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities

Claridge, B., Lozano, J., Poh, Q. H., & Greening, D. W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.734720 · Cited by 235 · see citing works

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro‐inflammatory and anti‐inflammatory agents: key role for TNF‐α

Michlewska, S., Dransfield, I., Megson, I. L., & Rossi, A. G. (2008) · The FASEB Journal · doi:10.1096/fj.08-121228 · Cited by 228 · see citing works

Phagocytosis of apoptotic cells and the resolution of inflammation

MADERNA, P., & Godson, C. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2003.09.004 · Cited by 223 · see citing works

“Eat me” and “don't eat me” signals govern the innate immune response and tissue repair in the CNS: emphasis on the critical role of the complement system

Elward, K. (2003) · Molecular Immunology · doi:10.1016/s0161-5890(03)00109-3 · Cited by 219 · see citing works

Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

Gregory, C. D., & Pound, J. D. (2010) · The Journal of Pathology · doi:10.1002/path.2792 · Cited by 214 · see citing works

Apoptotic Bodies Convey Activity Capable of Initiating Osteoclastogenesis and Localized Bone Destruction

Kogianni, G., Mann, V., & Noble, B. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080207 · Cited by 221 · see citing works

Resolution of inflammation: Mechanisms and opportunity for drug development

Alessandri, A. L., Sousa, L. P., Lucas, C. D., Rossi, A. G., Pinho, V., & Teixeira, M. M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.04.006 · Cited by 217 · see citing works

Platelet PECAM-1 inhibits thrombus formation in vivo

Falati, S., Patil, S. P., Gross, P. L., Stapleton, M. A., Merrill‐Skoloff, G., Barrett, N. E., Pixton, K. L., Weiler, H., Cooley, B. C., Newman, D. K., et al. (2005) · Blood · doi:10.1182/blood-2005-04-1512 · Cited by 213 · see citing works

Cell Removal: Efferocytosis

Henson, P. M. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125315 · Cited by 208 · see citing works

Constitutive exposure of phosphatidylserine on viable cells

Segawa, K., Suzuki, J., & Nagata, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114799108 · Cited by 206 · see citing works

Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation

Westman, J., Grinstein, S., & Marques, P. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03030 · Cited by 206 · see citing works

Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells

Krysko, D. V., Denecker, G., Festjens, N., Gabriëls, S., Parthoens, E., D'Herde, K. G. M. A., & Vandenabeele, P. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401900 · Cited by 197 · see citing works

Innate Immune Discrimination of Apoptotic Cells: Repression of Proinflammatory Macrophage Transcription Is Coupled Directly to Specific Recognition

Cvetanović, M., & Ucker, D. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.2.880 · Cited by 191 · see citing works

Dying cell clearance and its impact on the outcome of tumor radiotherapy

Lauber, K., Ernst, A., Orth, M., i, M. H., & Belka, C. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00116 · Cited by 186 · see citing works

Engulfment signals and the phagocytic machinery for apoptotic cell clearance

Park, S., & Kim, I. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.52 · Cited by 187 · see citing works

Phagocytosis of Staphylococcus aureus by Human Neutrophils Prevents Macrophage Efferocytosis and Induces Programmed Necrosis

Greenlee‐Wacker, M. C., Rigby, K. M., Kobayashi, S. D., Porter, A. R., DeLeo, F. R., & Nauseef, W. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302692 · Cited by 185 · see citing works

Macrophage phagocytosis after spinal cord injury: when friends become foes

Broeckhoven, J. V., Sommer, D., Dooley, D., Hendrix, S., & Franssen, A. J. P. M. (2021) · Brain · doi:10.1093/brain/awab250 · Cited by 177 · see citing works

The unfolding tale of PECAM‐1

Jackson, D. E. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00224-2 · Cited by 175 · see citing works

The Role of Neutrophils and Monocytes in Innate Immunity

Kantari‐Mimoun, C., Pederzoli-Ribeil, M., & Witko‐Sarsat, V. (2008) · KARGER eBooks · doi:10.1159/000136335 · Cited by 168 · see citing works

Efferocytosis in atherosclerosis

Adkar, S. S., & Leeper, N. J. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01037-7 · Cited by 166 · see citing works

The role of phosphatidylserine recognition receptors in multiple biological functions

Naeini, M. B., Bianconi, V., Pirro, M., & Sahebkar, A. (2020) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-00214-z · Cited by 156 · see citing works

Efferocytosis in the tumor microenvironment

Werfel, T. A., & Cook, R. S. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0698-5 · Cited by 156 · see citing works

Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death

Klöditz, K., & Fadeel, B. (2019) · Cell Death Discovery · doi:10.1038/s41420-019-0146-x · Cited by 150 · see citing works

Engulfment of Apoptotic Cells Is Negatively Regulated by Rho-mediated Signaling

Tosello‐Trampont, A., Nakada‐Tsukui, K., & Ravichandran, K. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306079200 · Cited by 153 · see citing works

Interactions of tumor cells with dendritic cells: balancing immunity and tolerance

Dhodapkar, M. V., Dhodapkar, K. M., & Palucka, A. K. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402247 · Cited by 147 · see citing works

PPARγ‐dependent regulation of human macrophages in phagocytosis of apoptotic cells

Majai, G. E., Sarang, Z., Csomós, K., Zahuczky, G., & Fésüs, L. (2007) · European Journal of Immunology · doi:10.1002/eji.200636398 · Cited by 146 · see citing works

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

Grabiec, A. M., & Hussell, T. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0555-3 · Cited by 144 · see citing works

Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases

Benedetto, P. D., Ruscitti, P., Vadasz, Z., Toubi, E., & Giacomelli, R. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102369 · Cited by 139 · see citing works

The consequences of apoptosis in autoimmunity

Lleò, A., Selmi, C. F., Invernizzi, P., Podda, M., & Gershwin, M. E. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.04.009 · Cited by 140 · see citing works

Efferocytosis and Its Role in Inflammatory Disorders

Ge, Y., Huang, M., & Yao, Y.-M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.839248 · Cited by 139 · see citing works

Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms

Tajbakhsh, A., Rezaee, M., Kovanen, P. T., & Sahebkar, A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.003 · Cited by 134 · see citing works

Persistence of apoptotic cells without autoimmune disease or inflammation in CD14−/− mice

Devitt, A., Parker, K. G., Ogden, C. A., Oldreive, C., Clay, M. F., Melville, L. A., Bellamy, C. O. C., Lacy‐Hulbert, A., Gangloff, S. C., Goyert, S. M., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200410057 · Cited by 135 · see citing works

Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis

Ji, R. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0848-6 · Cited by 132 · see citing works

The Multiple Roles of the Innate Immune System in the Regulation of Apoptosis and Inflammation in the Brain

Griffiths, M., Gasque, P., & Neal, J. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181996688 · Cited by 130 · see citing works

Immune Response Against Dying Tumor Cells

Zitvogel, L., Casares, N., Péquignot, M. O., Chaput, N., Albert, M. L., & Kroemer, G. (2004) · Advances in immunology · doi:10.1016/s0065-2776(04)84004-5 · Cited by 129 · see citing works

Macrophages in the embryo and beyond: Much more than just giant phagocytes

Ovchinnikov, D. A. (2008) · genesis · doi:10.1002/dvg.20417 · Cited by 127 · see citing works

Periodontitis

Schaudinn, C., Gorur, A., Keller, D. C., Sedghizadeh, P. P., & Costerton, J. W. (2009) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2009.0307 · Cited by 125 · see citing works

Proteomic characterization of macro-, micro- and nano-extracellular vesicles derived from the same first trimester placenta: relevance for feto-maternal communication

Tong, M., Kleffmann, T., Pradhan, S., Johansson, C. L., DeSousa, J., STONE, P. R., James, J. L., Chen, Q., & Chamley, L. (2016) · Human Reproduction · doi:10.1093/humrep/dew004 · Cited by 124 · see citing works

Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications

Szondy, Z., Garabuczi, Ã., Joós, G., Tsay, G. J., & Sarang, Z. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00354 · Cited by 124 · see citing works

Enhanced Susceptibility to Endotoxic Shock and Impaired STAT3 Signaling in CD31-Deficient Mice

Carrithers, M. D., Tandon, S., Canosa, S., Michaud, M., Graesser, D., & Madri, J. A. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62243-2 · Cited by 123 · see citing works

Macrophage phagocytosis: effects of environmental pollutants, alcohol, cigarette smoke, and other external factors

Karavitis, J., & Kovacs, E. J. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0311114 · Cited by 120 · see citing works

Eat‐me signals: Keys to molecular phagocyte biology and “Appetite” control

Li, W. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22815 · Cited by 120 · see citing works

CD31 as a Therapeutic Target in Atherosclerosis

Caligiuri, G. (2020) · Circulation Research · doi:10.1161/circresaha.120.315935 · Cited by 120 · see citing works

Death Detection

(2002) · Science s STKE · doi:10.1126/stke.2002.141.tw249

CD31 promotes β1 integrin-dependent engulfment of apoptotic Jurkat T lymphocytes opsonized for phagocytosis by fibronectin

Vernon-Wilson, E. F., Aurade, F., & Brown, S. B. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1005571 · Cited by 23 · see citing works

Controlling phagocytosis: brief encounter or death embrace?

Dewson, G. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02195-3

Role of CD31 Binding Partners in Viable Leukocyte Detachment from Macrophages

Wilkinson, K. (2007) · OpenGrey (Institut de l'Information Scientifique et Technique)

Macrophage Recognition of ICAM-3 on Apoptotic Leukocytes

Moffatt, O., Devitt, A., Bell, E. D., Simmons, D. L., & Gregory, C. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6800 · Cited by 185 · see citing works