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Novel IL-12 family members shed light on the orchestration of Th1 responses
Open accessAbstract
Interleukin-12 (IL-12), which is composed of a p35 and a p40 subunit, is a proinflammatory natural-killer (NK) cell-stimulating, Th1-inducing and Th1-maintaining cytokine, which promotes cell-mediated immunity. On activation, heterodimeric IL-12 is found in small amounts, whereas free p40 is produced in excess. Besides IL-12, other p40-dependent molecules exist that orchestrate Th1 responses. Homodimeric p40 can act as an IL-12 antagonist by competing for its receptor. Recent data also reveal potential immunostimulatory functions of p40. In addition, p40 can be covalently linked to a p35-related protein p19. This heterodimer is known as IL-23 and has activities on memory T cells. Finally, IL-27, the latest addition to this family, is a heterodimer composed of the p40-related protein EBI3 (Epstein–Barr virus-induced gene 3) and the p35-related protein p28. IL-27 is involved in early Th1 initiation.
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Cites
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
Kaplan, M. H., Sun, Y.-L., Hoey, T., & Grusby, M. J. (1996) · Nature · doi:10.1038/382174a0 · Cited by 1,240
Cited by
The 3 major types of innate and adaptive cell-mediated effector immunity
Annunziato, F., Romagnani, C., & Romagnani, S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.001 · Cited by 818
Vanden Eijnden, S., Goriely, S., De Wit, D., Willems, F., & Goldman, M. (2005) · European Journal of Immunology · doi:10.1002/eji.200425677 · Cited by 148
Menzies, F. M., Henriquez, F. L., Alexander, J., & Roberts, C. W. (2010) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2009.04086.x · Cited by 90
Metadata
- Authors
- Brombacher, F.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 24
- Issue
- 4
- Pages
- 207-212
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W1964909764
- Cited by
- 269
- References
- 1
- FWCI
- 15.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brombacher, F. (2003). Novel IL-12 family members shed light on the orchestration of Th1 responses. Trends in Immunology. https://doi.org/10.1016/s1471-4906(03)00067-x
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