Fluoroquinolone resistance among Gram-positive cocci

Hooper, David C

doi:10.1016/s1473-3099(02)00369-9

Cited by 320Antimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaAntibiotic Use and Resistance

Fluoroquinolone resistance among Gram-positive cocci

Hooper, David C·2002·The Lancet Infectious Diseases

DOI 10.1016/s1473-3099(02)00369-9

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Abstract

Resistance to fluoroquinolones among Gram-positive cocci has emerged as these antimicrobial agents have become extensively used in clinical medicine. Resistance is effected by changes in the bacterial target enzymes DNA gyrase and topoisomerase IV, which reduce drug binding, and by action of native bacterial membrane pumps that remove drug from the cell. In both cases, quinolone exposure selects for spontaneous mutants that are present in large bacterial populations, and which contain chromosomal mutations that alter the target protein or increase the level of pump expression. Resistance among clinical isolates has been greatest in Staphylococcus aureus and particularly among meticillin-resistant strains, in which both selection by quinolone exposure and transmission of clonal strains in health-care settings have contributed to high prevalence. Resistance in Streptococcus pneumoniae has also emerged in the community. Fluoroquinolone resistance has arisen in multidrug-resistant clones and its prevalence has been especially high in Hong Kong and Spain. Further spread and selection of such resistance could compromise the utility of a valuable class of antimicrobial agents, a point that emphasises the importance of the careful use of these agents in appropriate patients and doses, as well as careful infection-control practices.

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Clinically relevant fluoroquinolone resistance frequently requires accumulation of genetic changes over time, with the first mutation producing minor increases in MIC.
“Thus, in contrast to the case of RIF, clinically relevant FQ resistance frequently requires an accumulation of genetic changes over time, with the first mutation producing minor increases in the MIC (59).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [59]

Effectiveness of a hospital-wide programme to improve compliance with hand hygiene
Pittet, D., Hugonnet, S., Harbarth, S., Mourouga, P., Sauvan, V., Touveneau, S., & Perneger, T. V. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02814-2 · Cited by 2,524 · see citing works
Practice Guidelines for the Management of Community-Acquired Pneumonia in Adults
Bartlett, J. G., Dowell, S. F., Mandell, L. A., File, T. M., Musher, D. M., & Fine, M. J. (2000) · Clinical Infectious Diseases · doi:10.1086/313954 · Cited by 2,277 · see citing works
Guidelines for the Management of Adults with Community-acquired Pneumonia
Niederman, M. S., Mandell, L. A., Anzueto, A., Bass, J. B., Broughton, W. A., Campbell, G. D., Dean, N. C., File, T. M., Fine, M. J., Gross, P. A., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.7.at1010 · Cited by 2,145 · see citing works
DNA gyrase, topoisomerase IV, and the 4-quinolones
Drlica, K., & Zhao, X. (1997) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.61.3.377-392.1997 · Cited by 1,272 · see citing works
Quinolone resistance from a transferable plasmid
Martı́nez-Martı́nez, L., Pascual, Á., & Jacoby, G. A. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07322-4 · Cited by 1,104 · see citing works
Proton-dependent multidrug efflux systems
Paulsen, I. T., Brown, M. H., & Skurray, R. A. (1996) · Microbiological Reviews · doi:10.1128/mr.60.4.575-608.1996 · Cited by 1,089 · see citing works
Decreased Susceptibility ofStreptococcus pneumoniaeto Fluoroquinolones in Canada
Chen, D. K., McGeer, A., de Azavedo, J. C. S., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410403 · Cited by 996 · see citing works
Increasing Prevalence of Multidrug-Resistant<i>Streptococcus pneumoniae</i>in the United States
Whitney, C. G., Farley, M. M., Hadler, J., Harrison, L. H., Lexau, C., Reingold, A., Lefkowitz, L., Cieslak, P. R., Cetron, M., Zell, E. R., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012283432603 · Cited by 888 · see citing works
Molecular Properties of Bacterial Multidrug Transporters
Putman, M., van Veen, H. W., & Konings, W. N. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.672-693.2000 · Cited by 792 · see citing works
Trends in Antimicrobial Drug Prescribing Among Office-Based Physicians in the United States
McCaig, L. F. (1995) · JAMA · doi:10.1001/jama.1995.03520270048030 · Cited by 790 · see citing works
Mutation Frequencies and Antibiotic Resistance
Martínez, J. L., & Baquero, F. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.7.1771-1777.2000 · Cited by 701 · see citing works
Management of Community-Acquired Pneumonia in the Era of Pneumococcal Resistance
Heffelfinger, J. D. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.10.1399 · Cited by 612 · see citing works
Resistance to Levofloxacin and Failure of Treatment of Pneumococcal Pneumonia
Davidson, R., Cavalcanti, R. B., BRUNTON, J. L., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012122 · Cited by 539 · see citing works
Antimicrobial Resistance among Clinical Isolates of Streptococcus pneumoniae in the United States during 1999–2000, Including a Comparison of Resistance Rates since 1994–1995
Doern, G. V., Heilmann, K. P., Huynh, H. K., Rhomberg, P. R., Coffman, S. L., & Brueggemann, A. B. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.6.1721-1729.2001 · Cited by 537 · see citing works
Antimicrobial Use and Antimicrobial Resistance: A Population Perspective
Lipsitch, M., & Samore, M. H. (2002) · Emerging Infectious Diseases · doi:10.3201/eid0804.010312 · Cited by 497 · see citing works
Mechanisms of fluoroquinolone resistance
Hooper, D. C. (1999) · Drug Resistance Updates · doi:10.1054/drup.1998.0068 · Cited by 490 · see citing works
Self-citation
Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones
Yoshida, H., Bogaki, M., Nakamura, S., Ubukata, K., & Konno, M. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.12.6942-6949.1990 · Cited by 479 · see citing works
Treatment of severe pneumonia in hospitalized patients: results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenem-cilastatin. The Severe Pneumonia Study Group
Fink, M. P., Snydman, D. R., Niederman, M. S., Leeper, K. V., Johnson, R. H., Heard, S. O., Wunderink, R. G., Caldwell, J. W., Schentag, J. J., & Siami, G. A. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.3.547 · Cited by 458 · see citing works
Proton-dependent multidrug efflux systems.
Paulsen, I. T., Brown, M. H., & Skurray, R. A. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.4.575-608.1996 · Cited by 448 · see citing works
DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities
Levine, C., Hiasa, H., & Marians, K. J. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00126-2 · Cited by 392 · see citing works
A multicenter, randomized study comparing the efficacy and safety of intravenous and/or oral levofloxacin versus ceftriaxone and/or cefuroxime axetil in treatment of adults with community-acquired pneumonia
File, T. M., Segreti, J., Dunbar, L., Player, R., Kohler, R. B., Williams, R. R., Kojak, C., & Rubin, A. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.9.1965 · Cited by 360 · see citing works
Rapid Development of Ciprofloxacin Resistance in Methicillin-Susceptible and -Resistant Staphylococcus aureus
Blumberg, H. M., Rimland, D., Carroll, D. J., Terry, P. M., & Wachsmuth, I. K. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/163.6.1279 · Cited by 317 · see citing works
The Population Genetics of Antibiotic Resistance
Levin, B. R., Lipsitch, M., Perrot, V., Schrag, S. J., Antia, R., Simonsen, L., Walker, N., & Stewart, F. M. (1997) · Clinical Infectious Diseases · doi:10.1093/clinids/24.supplement_1.s9 · Cited by 315 · see citing works
Scheduled Change of Antibiotic Classes
KOLLEF, M. H., Vlasnik, J. J., Sharpless, L., Pasque, C., Murphy, D. M., & Fraser, V. J. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.4.9701046 · Cited by 295 · see citing works
Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples
Nikaido, H., & Thanassi, D. G. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.7.1393 · Cited by 284 · see citing works
Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae
Gill, M. J., Brenwald, N. P., & Wise, R. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.1.187 · Cited by 259 · see citing works
A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex
Willmott, C., & Maxwell, A. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.1.126 · Cited by 253 · see citing works
Emergence of Fluoroquinolone Resistance among Multiply Resistant Strains of Streptococcus pneumoniae in Hong Kong
Ho, P., Que, T., Tsang, D. N., et al. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.5.1310 · Cited by 243 · see citing works
Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus
Ng, E. Y., Trucksis, M., & Hooper, D. C. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.8.1881 · Cited by 233 · see citing works
Self-citation
Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome
Ng, E. Y., Trucksis, M., & Hooper, D. C. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.6.1345 · Cited by 226 · see citing works
Self-citation
Risk Factors for Acquisition of Levofloxacin-Resistant Streptococcus pneumoniae: A Case-Control Study
Ho, P., Tse, W. S., Tsang, K., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/319222 · Cited by 218 · see citing works
Epidemiology and frequency of resistance among pathogens causing urinary tract infections in 1,510 hospitalized patients: A report from the SENTRY Antimicrobial Surveillance Program (North America)
Mathai, D., Jones, R. N., & Pfaller, M. A. (2001) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(01)00254-1 · Cited by 217 · see citing works
DNA Gyrase and Topoisomerase IV Are Dual Targets of Clinafloxacin Action in Streptococcus pneumoniae
Pan, X.-S., & Fisher, L. M. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.11.2810 · Cited by 215 · see citing works
Low-level antibacterial resistance: a gateway to clinical resistance
Baquero, F. (2001) · Drug Resistance Updates · doi:10.1054/drup.2001.0196 · Cited by 193 · see citing works
New Uses for New and Old Quinolones and the Challenge of Resistance
Hooper, D. C. (2000) · Clinical Infectious Diseases · doi:10.1086/313677 · Cited by 169 · see citing works
Self-citation
Bacteria lacking a multidrug pump: A sensitive tool for drug discovery
Hsieh, P.-C., Siegel, S. A., Rogers, B. L., Davis, D., & Lewis, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6602 · Cited by 167 · see citing works
The Mechanism of Inhibition of Topoisomerase IV by Quinolone Antibacterials
Khodursky, A. B., & Cozzarelli, N. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27668 · Cited by 163 · see citing works
The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus
Schmitz, F., Fluit, A. C., Lückefahr, M., Engler, B., Hofmann, B., Verhoef, J., Heinz, H., Hadding, U., & Jones, M. E. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/42.6.807 · Cited by 161 · see citing works
Prevalence of gyrA , gyrB , parC , and parE Mutations in Clinical Isolates of Streptococcus pneumoniae with Decreased Susceptibilities to Different Fluoroquinolones and Originating from Worldwide Surveillance Studies during the 1997-1998 Respiratory Season
Jones, M. E., Sahm, D. F., Martin, N., et al. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.2.462-466.2000 · Cited by 158 · see citing works
Characteristics of pathogens causing urinary tract infections in hospitals in North America: results from the SENTRY Antimicrobial Surveillance Program, 1997
Jones, R. N., Kugler, K. C., Pfaller, M. A., et al. (1999) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(98)00158-8 · Cited by 155 · see citing works
High Rates of Multiple Antibiotic Resistance inStreptococcus pneumoniaeFrom Healthy Children Living in Isolated Rural Communities: Association With Cephalosporin Use and Intrafamilial Transmission
Samore, M. H., Magill, M. K., Alder, S. C., Severina, E. P., Boer, L. M.-D., Lyon, J. L., Carroll, K. C., Leary, J., Stone, M. B., Bradford, D. C., et al. (2001) · PEDIATRICS · doi:10.1542/peds.108.4.856 · Cited by 146 · see citing works
Induction of SOS genes in Escherichia coli and mutagenesis in Salmonella typhimurium by fluoroquinolones
Ysern, P., Clerch, B., Castańo, M., et al. (1990) · Mutagenesis · doi:10.1093/mutage/5.1.63 · Cited by 143 · see citing works
Fluoroquinolone Resistance in Streptococcus pneumoniae in United States since 1994-1995
Brueggemann, A. B., Coffman, S. L., Rhomberg, P. R., et al. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.3.680-688.2002 · Cited by 142 · see citing works
Excretion of ciprofloxacin in sweat and multiresistant Staphylococcus epidermidis
Høiby, N., Jarløv, J. O., Kemp, M., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09229-x · Cited by 141 · see citing works
Emergence of Ciprofloxacin-Resistant Coagulase-Negative Staphylococcal Skin Flora in Immunocompromised Patients Receiving Ciprofloxacin
Kotilainen, P., NIKOSKELAINEN, J., & Huovinen, P. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/161.1.41 · Cited by 138 · see citing works
Degradation of the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum: identification of metabolites
Wetzstein, H.-G., Schmeer, N., & Karl, W. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.11.4272-4281.1997 · Cited by 135 · see citing works
Antimicrobial Susceptibility of Bacillus Anthracis
Doğanay, M., & Aydın, N. (1991) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365549109024319 · Cited by 133 · see citing works
Characterization of emeA , a norA Homolog and Multidrug Resistance Efflux Pump, in Enterococcus faecalis
Jonas, B. M., Murray, B. E., & Weinstock, G. M. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.12.3574-3579.2001 · Cited by 133 · see citing works
High Prevalence of Oxacillin-Resistant Staphylococcus aureus Isolates from Hospitalized Patients in Asia-Pacific and South Africa: Results from SENTRY Antimicrobial Surveillance Program, 1998-1999
Bell, J. M., & Turnidge, J. D. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.3.880-882.2002 · Cited by 133 · see citing works
Characterization of grlA , grlB , gyrA , and gyrB Mutations in 116 Unrelated Isolates of Staphylococcus aureus and Effects of Mutations on Ciprofloxacin MIC
Schmitz, F., Jones, M. E., Hofmann, B., et al. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.5.1249 · Cited by 133 · see citing works
Measuring and Interpreting Associations between Antibiotic Use and Penicillin Resistance in Streptococcus pneumoniae
Lipsitch, M. (2001) · Clinical Infectious Diseases · doi:10.1086/319604 · Cited by 130 · see citing works
Mechanisms of Quinolone Resistance
Hooper, D. C. (2014) · ASM Press eBooks · doi:10.1128/9781555817817.ch3 · Cited by 128 · see citing works
Self-citation
Mutant Prevention Concentration as a Measure of Antibiotic Potency: Studies with Clinical Isolates of Mycobacterium tuberculosis
Dong, Y., Zhao, X., Kreiswirth, B. N., & Drlica, K. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2581-2584.2000 · Cited by 128 · see citing works
Expression of the Multidrug Resistance Transporter NorA from Staphylococcus aureus Is Modified by a Two-Component Regulatory System
Fournier, B., Aras, R. A., & Hooper, D. C. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.3.664-671.2000 · Cited by 126 · see citing works
Self-citation
Target Preference of 15 Quinolones againstStaphylococcus aureus, Based on Antibacterial Activities and Target Inhibition
Takei, M., Fukuda, H., Kishii, R., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.12.3544-3547.2001 · Cited by 122 · see citing works
Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae : Contributions of Type II Topoisomerase Mutations and Efflux to Levels of Resistance
Bast, D. J., Low, D. E., Duncan, C. L., et al. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.3049-3054.2000 · Cited by 122 · see citing works
Mutants of the Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine
Ahmed, M., Borsch, C. M., Neyfakh, A. A., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82095-6 · Cited by 121 · see citing works
Induction of Fibronectin-Binding Proteins and Increased Adhesion of Quinolone-ResistantStaphylococcus aureusby Subinhibitory Levels of Ciprofloxacin
Bisognano, C., Vaudaux, P. E., Rohner, P., Lew, D. P., & Hooper, D. C. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.6.1428-1437.2000 · Cited by 119 · see citing works
Self-citation
A Nosocomial Outbreak of Fluoroquinolone‐ResistantStreptococcus pneumoniae
Weiss, K., Restieri, C., Gauthier, R., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/322658 · Cited by 117 · see citing works
Degradation of the Fluoroquinolone Enrofloxacin by the Brown Rot Fungus Gloeophyllum striatum : Identification of Metabolites
Wetzstein, H.-G., Schmeer, N., & Karl, W. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.3.1166-1166.1998 · Cited by 117 · see citing works
Streptococcus pneumoniae DNA Gyrase and Topoisomerase IV: Overexpression, Purification, and Differential Inhibition by Fluoroquinolones
Pan, X.-S., & Fisher, L. M. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.5.1129 · Cited by 115 · see citing works
Fluoroquinolone‐ResistantStreptococcus pneumoniaeAssociated with Levofloxacin Therapy
Urban, C. M., Rahman, N. A., Zhao, X., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/323086 · Cited by 113 · see citing works
Infectious Complications with Respiratory Pathogens despite Ciprofloxacin Therapy
Lee, B. L., Padula, A. M., Kimbrough, R. C., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108153250719 · Cited by 113 · see citing works
Inhibition of the multidrug transporter NorA prevents emergence of norfloxacin resistance in Staphylococcus aureus
Markham, P. N., & Neyfakh, A. A. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.11.2673 · Cited by 112 · see citing works
Active efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae
Zeller, V., Janoir, C., Kitzis, M.-D., et al. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.9.1973 · Cited by 112 · see citing works
Efflux-Mediated Resistance to Fluoroquinolones in Gram-Positive Bacteria and the Mycobacteria
Poole, K. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.10.2595-2599.2000 · Cited by 111 · see citing works
Relationship between ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and moxifloxacin (BAY 12-8039) MICs and mutations in grlA, grlB, gyrA and gyrB in 116 unrelated clinical isolates of Staphylococcus aureus
Schmitz, F. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/41.4.481 · Cited by 106 · see citing works
In vitro resistance of Bacillus anthracis Sterne to doxycycline, macrolides and quinolones
Brook, I., Elliott, T. B., Pryor, H. I., Sautter, T. E., Gnade, B. T., Thakar, J. H., & Knudson, G. B. (2001) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(01)00464-2 · Cited by 103 · see citing works
NorA Functions as a Multidrug Efflux Protein in both Cytoplasmic Membrane Vesicles and Reconstituted Proteoliposomes
Yu, J., Grinius, L., & Hooper, D. C. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.5.1370-1377.2002 · Cited by 103 · see citing works
Self-citation
Mutations in Topoisomerase IV and DNA Gyrase of Staphylococcus aureus : Novel Pleiotropic Effects on Quinolone and Coumarin Activity
Fournier, B., & Hooper, D. C. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.1.121 · Cited by 95 · see citing works
Self-citation
Antimicrobial Resistance among Clinical Isolates of Streptococcus pneumoniae in Canada during 2000
Low, D. E., de Azavedo, J., Weiss, K., et al. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.5.1295-1301.2002 · Cited by 93 · see citing works
Horizontal Transfer of parC and gyrA in Fluoroquinolone-Resistant Clinical Isolates of Streptococcus pneumoniae
Ferrándiz, M.-J., Fenoll, A., Liñares, J., & de la Campa, A. G. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.4.840-847.2000 · Cited by 91 · see citing works
Ciprofloxacin Resistance among Nosocomial Pseudomonas aeruginosa and Staphylococcus aureus in the United States
Coronado, V. G., Edwards, J. R., Culver, D. H., et al. (1995) · Infection Control and Hospital Epidemiology · doi:10.2307/30140945 · Cited by 89 · see citing works
Epidemiologic typing of Staphylococcus aureus by DNA restriction fragment length polymorphisms of rRNA genes: elucidation of the clonal nature of a group of bacteriophage-nontypeable, ciprofloxacin-resistant, methicillin-susceptible S. aureus isolates
Blumberg, H. M., Rimland, D., Kiehlbauch, J. A., et al. (1992) · Journal of Clinical Microbiology · doi:10.1128/jcm.30.2.362-369.1992 · Cited by 88 · see citing works
Levofloxacin Failure in a Patient with Pneumococcal Pneumonia
Empey, P. E., Jennings, H. R., Thornton, A., et al. (2001) · Annals of Pharmacotherapy · doi:10.1345/aph.10229 · Cited by 87 · see citing works
Therapeutic failure and selection of resistance to quinolones in a case of pneumococcal pneumonia treated with ciprofloxacin
Pérez‐Trallero, E., García-Arenzana, J. M., Jimenez, J. A., et al. (1990) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01967510 · Cited by 85 · see citing works
Expression of Efflux Pump Gene pmrA in Fluoroquinolone-Resistant and -Susceptible Clinical Isolates of Streptococcus pneumoniae
Piddock, L. J. V., Johnson, M. M., Simjee, S., & Pumbwe, L. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.3.808-812.2002 · Cited by 85 · see citing works
Genetic Diversity and Clonal Patterns among Antibiotic-Susceptible and -Resistant Streptococcus pneumoniae Colonizing Children: Day Care Centers as Autonomous Epidemiological Units
Sá‐Leão, R., Tomasz, A., Santos‐Sanches, I., et al. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.11.4137-4144.2000 · Cited by 85 · see citing works
Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus
Takenouchi, T., Tabata, F., Iwata, Y., et al. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.8.1835 · Cited by 83 · see citing works
The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin
Brenwald, N. P. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/40.3.458 · Cited by 75 · see citing works
Activity of quinolones in the Ames Salmonella TA102 mutagenicity test and other bacterial genotoxicity assays
Mamber, S. W., Kolek, B., Brookshire, K. W., et al. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.2.213 · Cited by 72 · see citing works
Is there a role for antibiotic cycling in the intensive care unit?
Kollef, M. H. (2001) · Critical Care Medicine · doi:10.1097/00003246-200104001-00014 · Cited by 71 · see citing works
Analysis of Ciprofloxacin Activity against Streptococcus pneumoniae after 10 Years of Use in the United States
Sahm, D. F., Peterson, D. E., Critchley, I. A., et al. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2521-2524.2000 · Cited by 71 · see citing works
Emergence of quinolone resistance among clinical isolates of methicillin-resistant Staphylococcus aureus in Ontario, Canada
Harnett, N., Brown, S. N., & Krishnan, C. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.9.1911 · Cited by 70 · see citing works
Increasing resistance of enterococci to ciprofloxacin
Schaberg, D. R., Dillon, W. I., Terpenning, M. S., et al. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.11.2533 · Cited by 70 · see citing works
In Vitro Development of Resistance to Ofloxacin and Doxycycline in Bacillus anthracis Sterne
Choe, C. H., Bouhaouala, S. S., Brook, I., Elliott, T. B., & Knudson, G. B. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.6.1766-1766.2000 · Cited by 69 · see citing works
The Battle against Emerging Antibiotic Resistance: Should Fluoroquinolones Be Used to Treat Children?
Mandell, L. A., Peterson, L. R., Wise, R., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341900 · Cited by 67 · see citing works
Mechanisms and Frequency of Resistance to Gatifloxacin in Comparison to AM-1121 and Ciprofloxacin in Staphylococcus aureus
İnce, D., & Hooper, D. C. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.10.2755-2764.2001 · Cited by 66 · see citing works
Self-citation
A Mutation in the 5′ Untranslated Region Increases Stability of norA mRNA, Encoding a Multidrug Resistance Transporter of Staphylococcus aureus
Fournier, B., Truong, Q. C., Zhang, X., & Hooper, D. C. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.7.2367-2371.2001 · Cited by 65 · see citing works
Self-citation
Prevalence of Single Mutations in Topoisomerase Type II Genes among Levofloxacin-Susceptible Clinical Strains of Streptococcus pneumoniae Isolated in the United States in 1992 to 1996 and 1999 to 2000
Davies, T. A., Evangelista, A. T., Pfleger, S., et al. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.1.119-124.2002 · Cited by 64 · see citing works
Increased incidence of ciprofloxacin resistance in penicillin-resistant pneumococci in Northern Ireland
Goldsmith, C. E., Moore, J. E., Murphy, P. G., et al. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/41.3.420 · Cited by 59 · see citing works
Enterococcal superinfection in patients treated with ciprofloxacin
Zervos, M., Bacon, A. E., PATTERSON, J. E., et al. (1988) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/21.1.113 · Cited by 57 · see citing works
Antimicrobial Susceptibility of GBS
Kim, K. S. (2015) · Antibiotics and chemotherapy/Antibiotica et chemotherapia · doi:10.1159/000410363 · Cited by 57 · see citing works
Mechanisms and Frequency of Resistance to Premafloxacin in Staphylococcus aureus : Novel Mutations Suggest Novel Drug-Target Interactions
İnce, D., & Hooper, D. C. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.12.3344-3350.2000 · Cited by 53 · see citing works
Self-citation
Molecular epidemiology of quinolone resistance and comparative in vitro activities of new quinolones against EuropeanStaphylococcus aureusisolates
Schmitz, F., Fluit, A. C., Brisse, S., et al. (1999) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1999.tb01400.x · Cited by 47 · see citing works
Development of Resistance to Ciprofloxacin, Rifampin, and Mupirocin in Methicillin-Susceptible and -Resistant Staphylococcus aureus Isolates
Schmitz, F., Fluit, A. C., Häfner, D., et al. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.3229-3231.2000 · Cited by 46 · see citing works
Bipolar localization of Bacillus subtilis topoisomerase IV, an enzyme required for chromosome segregation
Huang, W. M., Libbey, J. L., van der Hoeven, P., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4652 · Cited by 46 · see citing works
Epidemiology of ciprofloxacin resistance among patients with methicillin-resistant Staphylococcus aureus
Smith, S. M. R., Eng, R. H. K., Bais, P., et al. (1990) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/26.4.567 · Cited by 43 · see citing works
The rapid emergence of fluoroquinolone-methicillin-resistant Staphylococcus aureus infections in a community hospital
Aldridge, K. E., Gelfand, M. S., Schiro, D. D., et al. (1992) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/0732-8893(90)90037-v · Cited by 41 · see citing works
Strategies for Stemming the Tide of Antimicrobial Resistance
Low, D. E. (1998) · JAMA · doi:10.1001/jama.279.5.394 · Cited by 41 · see citing works
Fluoroquinolone Resistance Associated with Target Mutations and Active Efflux in Oropharyngeal Colonizing Isolates of Viridans Group Streptococci
Guérin, F., Varon, E., Buu-Hoï, A., Gutmann, L., & Podglajen, I. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.8.2197-2200.2000 · Cited by 41 · see citing works
Evaluation of Susceptibility Testing To Detect Fluoroquinolone Resistance Mechanisms in Streptococcus pneumoniae
Richardson, D. C., Bast, D. J., McGeer, A., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.6.1911-1914.2001 · Cited by 38 · see citing works
In vitro activities of quinolones against enterococci resistant to penicillin-aminoglycoside synergy
Sahm, D. F., & Koburov, G. T. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.1.71 · Cited by 38 · see citing works
Multiply antibiotic-resistant Staphylococcus epidermidis in patients, staff and environment—a one-week survey in a bone marrow transplant unit
Hedin, G., & Hambræus, A. (1991) · Journal of Hospital Infection · doi:10.1016/0195-6701(91)90173-6 · Cited by 37 · see citing works
Influences of Different Factors on Prevalence of Ciprofloxacin Resistance in Streptococcus pneumoniae in Spain
Garcı́a-Rey, C., Aguilar, L., Baquero, F., et al. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.12.3481-3482.2000 · Cited by 37 · see citing works
Streptococcus pneumoniae Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Clonal Diversity and Appearance of Ciprofloxacin-Resistant Epidemic Clones
Alou, L., Ramirez, M., Garcı́a-Rey, C., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.10.2955-2957.2001 · Cited by 36 · see citing works
Interspecies Recombination Contributes Minimally to Fluoroquinolone Resistance in Streptococcus pneumoniae
Bast, D. J., de Azavedo, J. C. S., Tam, T. Y., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.9.2631-2634.2001 · Cited by 29 · see citing works
Activity and spectrum of BMS 284756, a new des-F (6) quinolone, tested against strains of ciprofloxacin-resistant Gram-positive cocci
Jones, R. N., Pfaller, M. A., & Stilwell, M. G. (2001) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(00)00233-9 · Cited by 29 · see citing works
The epidemiology of ciprofloxacin resistance in coagulase-negative staphylococci in CAPD patients.
Dryden, M., Talsania, H., McCann, M., et al. (1992) · PubMed · Cited by 26 · see citing works
Molecular characterization of epidemic ciprofloxacin- and methicillin-resistant Staphylococcus aureus strains colonizing patients in an intensive care unit
Udo, E. E., Al‐Obaid, I., Jacob, L. E., et al. (1996) · Journal of Clinical Microbiology · doi:10.1128/jcm.34.12.3242-3244.1996 · Cited by 26 · see citing works
Occurrence of quinolone resistance inStaphylococcus aureusfrom nosocomial infection
Witte, W., & Grimm, H. (1992) · Epidemiology and Infection · doi:10.1017/s0950268800050408 · Cited by 26 · see citing works
The Epidemiology of Resistance to Ofloxacin and Oxacillin Among Clinical Coagulase‐Negative Staphylococcal Isolates: Analysis of Risk Factors and Strain Types
Pegues, D. A., Colby, C., Hibberd, P. L., et al. (1998) · Clinical Infectious Diseases · doi:10.1086/516270 · Cited by 24 · see citing works
Guidelines for Community-Acquired Pneumonia: A Tale of 2 Countries
Mandell, L. A. (2000) · Clinical Infectious Diseases · doi:10.1086/313965 · Cited by 24 · see citing works
Epidemiology of the Colonization of Inpatients and Outpatients with Ciprofloxacin-Resistant Coagulase-Negative Staphylococci
Kotilainen, P., Huovinen, S., Jarvinen, H., et al. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/21.3.685 · Cited by 20 · see citing works
Emergence of extremely high penicillin and cefotaxime resistance and high-level levofloxacin resistance in clinical isolates of Streptococcus pneumoniae in Hungary
Glatz, K. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.5.731 · Cited by 20 · see citing works
Target site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolones
Ho, P., Yam, W. C., Que, T., et al. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/47.5.655 · Cited by 20 · see citing works
Fluoroquinolone Resistance Is a Poor Surrogate Marker for Type II Topoisomerase Mutations in Clinical Isolates of Streptococcus pneumoniae
Millichap, J. G., Pestova, E. V., Siddiqui, F., et al. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.7.2719-2721.2001 · Cited by 13 · see citing works
Use of Oral Ciprofloxacin in Community-Acquired Pneumonia
Chrysanthopoulos, C. J., & Bassaris, H. P. (1989) · Journal of Chemotherapy · doi:10.1080/1120009x.1989.11738874 · Cited by 7 · see citing works
[Inter- and intrahospital transmission of methicillin-resistant Staphylococcus aureus].
Harbarth, S., Romand, J.-A., Frei, R., et al. (1997) · PubMed · Cited by 6 · see citing works
A Randomized study comparing low dose ciprofloxacin and ofloxacin in the treatment of lower respiratory tract infections
Polubiec, A., Jórasz, I., Pietrzak, J., et al. (1994) · Infection · doi:10.1007/bf01780772 · Cited by 6 · see citing works
ANTIMICROBIAL-RESISTANT ENTEROCOCCAL ISOLATES FROM FLURROQUINOLONE-NAIVE CHILDREN
McNeeley, D. F., Eckert, S. J., & Noel, G. J. (2000) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-200007000-00029 · Cited by 4 · see citing works

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Outpatient antibiotic use in Europe and association with resistance: a cross-national database study
Goossens, H., Ferech, M., Vander Stichele, R., & Elseviers, M. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17907-0 · Cited by 3,359 · see citing works
Mechanisms of Antibiotic Resistance
Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782 · see citing works
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Munita, J. M., & Arias, C. A. (2016) · Virulence Mechanisms of Bacterial Pathogens · doi:10.1128/9781555819286.ch17 · Cited by 421 · see citing works

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Skepper, C. K., Armstrong, D., Balibar, C. J., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00347 · Cited by 40 · see citing works
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Pitondo‐Silva, A., Martins, V. V., da Silva, C. F., et al. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.07.018 · Cited by 13 · see citing works
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Reinhardt, A. K. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf158 · Cited by 46 · see citing works
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Heddle, J. G., & Maxwell, A. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1805-1815.2002 · Cited by 125 · see citing works

Authors: Hooper, D. C.
Affiliations: Harvard University (US)
Corresponding author: Hooper, David C
ORCID: Hooper, David C
Venue: The Lancet Infectious Diseases
Publisher: Elsevier BV
Published: 2002-09
Volume: 2
Issue: 9
Pages: 530-538
ISSN: 1473-3099 (ISSN-L)
DOI: 10.1016/s1473-3099(02)00369-9
OpenAlex: W2112722072
Semantic Scholar: 3c251cf65048f609225a47cc3018cef9840931c2
Cited by: 320
References: 121
Citations by year: 2026: 4 · 2025: 9 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 13 · 2019: 10 · 2018: 12 · 2017: 15 · 2016: 16 · 2015: 13 · 2014: 16 · 2013: 14 · 2012: 21
FWCI: 3.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI023988)
Topics: Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Keywords: fluoroquinolone resistance, Gram-positive cocci, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, DNA gyrase, topoisomerase IV, efflux pumps, multidrug resistance, clonal transmission, antimicrobial resistance, infection control, rational antibiotic use
MeSH terms: Anti-Infective Agents, Gram-Positive Bacteria, Humans, Microbial Sensitivity Tests, Fluoroquinolones, Drug Resistance, Multiple, Bacterial, DNA Gyrase

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Fluoroquinolone resistance among Gram-positive cocci

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