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Cited by 851Antibiotic Use and ResistanceAntibiotic Resistance in BacteriaSalmonella and Campylobacter epidemiology

Antimicrobial resistance in developing countries. Part I: recent trends and current status

Okeke, Iruka N, Laxminarayan, Ramanan, Bhutta, Zulfiqar A, Duse, Adriano G, Jenkins, Philip, O'Brien, Thomas F, Pablos-Mendez, Ariel, Klugman, Keith P·2005·The Lancet Infectious Diseases
DOI 10.1016/s1473-3099(05)70189-4
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Abstract

The global problem of antimicrobial resistance is particularly pressing in developing countries, where the infectious disease burden is high and cost constraints prevent the widespread application of newer, more expensive agents. Gastrointestinal, respiratory, sexually transmitted, and nosocomial infections are leading causes of disease and death in the developing world, and management of all these conditions has been critically compromised by the appearance and rapid spread of resistance. In this first part of the review, we have summarised the present state of resistance in these infections from the available data. Even though surveillance of resistance in many developing countries is suboptimal, the general picture is one of accelerating rates of resistance spurred by antimicrobial misuse and shortfalls in infection control and public health. Reservoirs for resistance may be present in healthy human and animal populations. Considerable economic and health burdens emanate from bacterial resistance, and research is needed to accurately quantify the problem and propose and evaluate practicable solutions. In part II, to be published next month, we will review potential containment strategies that could address this burgeoning problem.

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Crossref · 10.1016/s1473-3099(05)70189-4

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  • Due to insufficient sanitation services and animal waste management, antimicrobial-resistant bacteria selected through human and animal antibiotic use and misuse can be excreted into the same environments in which residents eat, work, and play.

    “First, due to insufficient sanitation services and animal waste management, antimicrobial-resistant bacteria that are selected through human and animal antibiotic use and misuse can be excreted into the same environments in which residents eat, work, and play 46 .”

    From Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission. (2020) · cites this paper as [46]

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Authors
Okeke, I. N., Laxminarayan, R., Bhutta, Z. A., Duse, A. G., Jenkins, P., O'Brien, T. F., Pablos-Mendez, A., & Klugman, K. P.
Affiliations
  • Haverford College (US)
  • Resources For The Future (US)
  • Aga Khan University (PK)
  • National Health Laboratory Service (ZA)
  • World Health Organization (CH)
  • Emory University (US)
Corresponding author
Klugman, Keith P
ORCID
Venue
The Lancet Infectious Diseases
Publisher
Elsevier BV
Published
2005-08
Volume
5
Issue
8
Pages
481-493
ISSN
1473-3099 (ISSN-L)
DOI
10.1016/s1473-3099(05)70189-4
OpenAlex
W2100819850
Cited by
851
References
4
Citations by year
2026: 25 · 2025: 35 · 2024: 40 · 2023: 40 · 2022: 39 · 2021: 61 · 2020: 60 · 2019: 67 · 2018: 58 · 2017: 40 · 2016: 43 · 2015: 51 · 2014: 59 · 2013: 35 · 2012: 39
FWCI
2.75
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Lancet Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords
antimicrobial resistance, developing countries, gastrointestinal infections, respiratory infections, sexually transmitted infections, nosocomial infections, antimicrobial misuse, infection control, resistance monitoring, containment strategies
MeSH terms
Adult, Child, Preschool, Communicable Diseases, Cross Infection, Developing Countries, Diarrhea, Drug Resistance, Microbial, Humans, Population Surveillance, Global Health, Prevalence, Tuberculosis, Multidrug-Resistant

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