Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis
Abstract
We set out to estimate the age and genotype-specific prevalence of cervical human papillomavirus (HPV) DNA in women with normal cervical cytology worldwide by meta-analysis of a systematic literature review. Reports on HPV prevalence published between January, 1995, and January, 2005, were retrieved. To be included, studies required information on cervical cytology, plus detailed descriptions of study populations, methods used to collect cervical samples, and assays used for HPV DNA detection and typing. Final analyses included 78 studies that could be separated into women with normal cytology, and of which subsets of 44 and 48 studies had data on age and type-specific HPV prevalence, respectively. Overall HPV prevalence in 157 879 women with normal cervical cytology was estimated to be 10.4% (95% CI 10.2-10.7). Corresponding estimates by region were Africa 22.1% (20.9-23.4), Central America and Mexico 20.4% (19.3-21.4), northern America 11.3% (10.6-12.1), Europe 8.1% (7.8-8.4), and Asia 8.0% (7.5-8.4). In all world regions, HPV prevalence was highest in women younger than 35 years of age, decreasing in women of older age. In Africa, the Americas, and Europe, a clear second peak of HPV prevalence was observed in women aged 45 years or older. On the basis of these estimates, around 291 million women worldwide are carriers of HPV DNA, of whom 32% are infected with HPV16 or HPV18, or both. The HPV types most commonly detected are similar to those most commonly described in pre-n…
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In India, overall HPV prevalence in women with normal cytology is 7.5%.
“In India, overall HPV prevalence in women with normal cytology has been estimated to be 7.5% (de Sanjosé et al, 2007).”
From Health and economic impact of HPV 16 and 18 vaccination and cervical cancer screening in India (2008) · cites this paper as de Sanjosé et al, 2007
Distribution of most common genotypes in ICC cases is also consistent with the types found worldwide.
“Distribution of most common genotypes in ICC cases is also consistent with the types found in worldwide [26, 27].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [26]
Synergistic effect of multiple infections by HPV genotypes on carcinogenesis is supported by many studies.
“Synergistic effect of multiple infections by HPV genotypes on carcinogenesis is supported by many studies [7–9, 17, 26], while contradicting studies [25, 29, 31, 32, 35] invoke confusion.”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [26]
Approximately more than 70% of worldwide invasive cervical cancer could be prevented by the available bivalent and quadrivalent HPV vaccines.
“Approximately, more than 70% worldwide ICC could be prevented by the available bivalent HPV vaccines-CervarixTM (GlaxoSmithKline Biologicals, Rixensart, Belgium) and quadrivalent HPV vaccine- Gardasil® (4vHPV) (Merck & Co., Inc., Kenilworth, NJ, USA) [26, 27].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [26]
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“Distribution of most common genotypes in ICC cases is also consistent with the types found in worldwide [26, 27].”
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- Authors
- de Sanjosé, S., Diaz, M., Castellsagué, X., Clifford, G., Bruni, L., Muñoz, N., & Bosch, F. X.
- Affiliations
- Institut Català d'Oncologia (ES)
- Centre international de recherche sur le cancer (FR)
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 7
- Issue
- 7
- Pages
- 453-459
- ISSN
- 1473-3099 (ISSN-L)
- OpenAlex
- W2139738127
- Cited by
- 1,669
- References
- 0
- Citations by year
- 2026: 58 · 2025: 67 · 2024: 71 · 2023: 109 · 2022: 89 · 2021: 102 · 2020: 79 · 2019: 93 · 2018: 79 · 2017: 83 · 2016: 85 · 2015: 78 · 2014: 100 · 2013: 119 · 2012: 107
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- human papillomavirus, HPV prevalence, HPV genotypes, normal cervical cytology, HPV16, HPV 18, age-specific prevalence, regional variation
- MeSH terms
- Adult, Age Factors, Cervix Uteri, DNA, Viral, Female, Genotype, Humans, Middle Aged, Global Health, Models, Statistical, Prevalence, Papillomaviridae, Papillomavirus Infections
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