Global burden and trends of sexually transmitted infections from 1990 to 2019: an observational trend study
Abstract
Background Sexually transmitted infections (STIs) are a major public health issue worldwide, but there is a paucity of literature on their burden and trends globally. We aimed to assess the global disease burden and trends of STIs from 1990 to 2019. Methods In this observational trend study, we collected data on incident cases, age-standardised incidence rate, and disability-adjusted life-years (DALYs), and calculated age-standardised DALY rates, for five STIs (syphilis, chlamydia, gonorrhoea, trichomonas, and genital herpes) between 1990 and 2019, by sex, geographical region, and cause using data exclusively from the Global Burden of Disease study 2019. The estimated annual percentage changes in the age-standardised incidence rate and age-standardised DALY rate were calculated to quantify the changing trend. Findings Globally, the age-standardised incidence rate of STIs showed a decreasing trend with an estimated annual percentage change of -0·04 (95% uncertainty interval [UI] -0·08 to 0·00) from 1990 to 2019, reaching 9535·71 per 100 000 person-years (8169·73 to 11 054·76) in 2019. The age-standardised DALY rate showed a decreasing trend with an estimated annual percentage change of -0·92 (-1·01 to -0·84) and reached 22·74 per 100 000 person-years (14·37 to 37·11) in 2019. The sub-Saharan African region had the highest age-standardised incidence rate (19 973·12 per 100 000 person-years, 17 382·69 to 23 001·57) and age-standardised DALY rate (389·32 per 100 000 person-years,…
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Bacterial vaginosis is more prevalent in women from African, Caribbean, and Black communities and is consistently associated with a 2-5-fold increase in HIV-1 risk.
“Moreover, the presence of BV, which is more prevalent in women from ACB communities [9–11], has been consistently associated with a 2-5-fold increase in HIV-1 risk [12, 13].”
Cites
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The growing epidemic of sexually transmitted infections in adolescents: a neglected population
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“Moreover, the presence of BV, which is more prevalent in women from ACB communities [9–11], has been consistently associated with a 2-5-fold increase in HIV-1 risk [12, 13].”
Shu, J.-T., Jiang, T., Li, C.-Y., Zou, M.-Y., Zhou, X.-Y., Zhuang, X., Zhang, B., Jiang, Y.-H., & Qin, G. (2025) · BMC Public Health · doi:10.1186/s12889-025-22515-8 · Cited by 5 · see citing works
- Authors
- Zheng, Y., Yu, Q., Lin, Y., Zhou, Y., Lan, L., Yang, S., & Wu, J.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
- Corresponding author
- Wu, Jie
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 22
- Issue
- 4
- Pages
- 541-551
- ISSN
- 1473-3099 (ISSN-L)
- OpenAlex
- W4200393569
- Cited by
- 262
- References
- 3
- Citations by year
- 2026: 40 · 2025: 73 · 2024: 70 · 2023: 49 · 2022: 29
- FWCI
- 26.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The Lancet Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- National Major Science and Technology Projects of China
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Social Sciences › General Social Sciences › HIV, TB, and STIs Epidemiology
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- sexually transmitted infections, disease burden, incidence trends, disability-adjusted life years, syphilis, chlamydia, gonorrhea, trichomoniasis, genital herpes, sub-Saharan Africa, adolescents, sex differences, Global Burden of Disease Study 2019, health policy implications, HIV prevention, health care financing
- MeSH terms
- Global Burden of Disease, Disability-Adjusted Life Years, Adolescent, Female, Humans, Male, Risk Factors, Syphilis, Global Health, Incidence, Quality-Adjusted Life Years
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