The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial
Open accessAbstract
Background Memantine has been used off-label to treat frontotemporal lobar degeneration (FTD). A previous 26-week open-label study suggested a transient, modest benefit on neuropsychiatric symptoms as measured by the neuropsychiatric inventory (NPI). We aimed to determine whether memantine is an effective treatment for FTD. Methods We did a randomised, parallel group, double-blind, placebo-controlled trial of 20 mg memantine taken orally daily for 26 weeks in patients with FTD. Participants met Neary criteria for behavioural variant FTD (bvFTD) or semantic dementia and had characteristic brain atrophy. Use of acetylcholinesterase inhibitors was prohibited. Individuals were randomly assigned to receive either memantine or matched placebo tablets (1:1) in blocks of two and four patients. All patients and study personnel were masked to treatment assignment. Primary endpoints were the change in total NPI score and clinical global impression of change (CGIC) score after 26 weeks and were analysed by intention to treat. This study is registered with Clinicaltrials.gov, number NCT00545974. Findings Of 100 patients screened, 81 were randomly assigned to receive memantine (39 patients) or placebo (42 patients). Five (6%) patients discontinued, and 76 completed the 26-week treatment. Enrolment numbers were lower than planned because of many patients' preference to take memantine or cholinesterase inhibitors off-label rather than participate in a clinical trial. Memantine treatment had no effect on either the NPI (mean difference 2·2, 95% CI -3·9 to 8·3, p=0·47) or CGIC (mean difference 0·0, -0·4 to 0·4, p=0·90) after 26 weeks of treatment. Memantine was generally well tolerated; however, patients in the memantine group had more frequent cognitive adverse events (six patients) than those in the placebo group (one). Interpretation Memantine treatment showed no benefit in patients with FTD. These data do not support memantine use in FTD. Funding Forest Research Institute.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Likewise memantine, an NMDA receptor antagonist, approved for moderate to severe AD, has shown no benefit in patients with bvFTD [38].”
From Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road (2017) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
Self-citationWeıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,018
Measurement of Functional Activities in Older Adults in the Community
PFEFFER, R. I., Kurosaki, T., Harrah, C. H., Chance, J. M., & Filos, S. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.3.323 · Cited by 2,978
The Neuropsychiatric Inventory
Cummings, J. L. (1997) · Neurology · doi:10.1212/wnl.48.5_suppl_6.10s · Cited by 2,055
Bédard, M., Molloy, D. W., Squire, L., Dubois, S., Lever, J. A., & O'Donnell, M. (2001) · The Gerontologist · doi:10.1093/geront/41.5.652 · Cited by 1,691
Tariot, P. N., Farlow, M. R., Grossberg, G. T., Graham, S. M., McDonald, S., Gergel, I., & for the Memantine Study Group (2004) · JAMA · doi:10.1001/jama.291.3.317 · Cited by 1,403
Schneider, L., Olin, J. T., Doody, R. S., Clark, C. M., Morris, J. C., Reisberg, ., Schmitt, F. A., Grundman, M., Thomas, R. G., & Ferris, S. H. (1997) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199700112-00004 · Cited by 646
Bedside Assessment of Executive Cognitive Impairment: The Executive Interview
Royall, D. R., Mahurin, R. K., & Gray, K. F. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb03646.x · Cited by 595
Cited by
Sorted by citations
Items 101–200 of 228
Frisoni, G. B., Perani, D., Bastianello, S., Bernardi, G., Porteri, C., Boccardi, M., Cappa, S. F., Trabucchi, M., & Padovani, A. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.033 · Cited by 18
Kertesz, A., & Harciarek, M. (2014) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12105 · Cited by 20
Meyer, P., McSweeney, M., Gonneaud, J., & Villeneuve, S. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.05.001 · Cited by 20
Dharmadasa, T., Matamala, J. M., Huynh, W., Zoing, M. C., & Kiernan, M. C. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63916-5.00022-7 · Cited by 18
Stockbridge, M. D. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-823384-9.00013-x · Cited by 17
Waldö, M. L. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.02.001 · Cited by 18
Byeon, G., Kang, D. W., Kim, Y., Kim, G. H., Kim, K. W., Kim, H.-J., Na, S., Park, K. H., Park, Y. H., Suh, J., et al. (2025) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2025.24.1.24 · Cited by 16
Clinical update on frontotemporal dementia: diagnosis and treatment
Mocellin, R., Scholes, A., Walterfang, M., Looi, J. C., & Velakoulis, D. (2015) · Australasian Psychiatry · doi:10.1177/1039856215582276 · Cited by 17
Fisher, T., Schwartz, A., Greenspan, H. N., & Heinrich, T. W. (2016) · International Journal of Psychiatry in Medicine · doi:10.1177/0091217416636579 · Cited by 19
Pan, L., Quan, W., Zhou, Y., Wang, Y., Zhang, H., & Liu, S. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3284 · Cited by 16
Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes
Murley, A. G., Tsvetanov, K. A., Rouse, M. A., Jones, P. S., Sværke, K., Li, W., Carpenter, A., & Rowe, J. B. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.10.012 · Cited by 16
Evaluation of Cognitive Impairment in Older Adults
Scharre, D. W., & Trzepacz, P. T. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.4.482 · Cited by 17
Effects of memantine treatment on language abilities and functional communication: A review of data
Tocco, M., Bayles, K. A., López, O. L., Hofbauer, R. K., Pejović, V., Miller, M. L., & Saxton, J. A. (2013) · Aphasiology · doi:10.1080/02687038.2013.838617 · Cited by 16
Gazzina, S., Manes, M. A., Padovani, A., & Borroni, B. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.056 · Cited by 21
Sanches, C., Lévy, R., Benisty, S., Volpe‐Gillot, L., Habert, M., Kas, A., Ströer, S., Pyatigorskaya, N., Kaglik, A., Bourbon, A., et al. (2019) · Trials · doi:10.1186/s13063-019-3613-z · Cited by 16
Perry, A., Hughes, L. E., Adams, N., Naessens, M., Murley, A. G., Rouse, M. A., Street, D., Jones, P. S., Cope, T., Kocagöncü, E., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02114-6 · Cited by 15
Treatment approaches in motor neurone disease
Dharmadasa, T., Matamala, J. M., & Kiernan, M. C. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000369 · Cited by 16
Lethin, C., Hallberg, I. R., Guiteras, A. R., Verbeek, H., Saks, K., Stolt, M., Zabalegui, A., Soto‐Martin, M., & Nilsson, C. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1174-3 · Cited by 17
Clark, D. G. (2024) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001506 · Cited by 14
Pharmacological Treatment of Dementia
Hahn, S. J., & Paik, N. (2015) · Brain & Neurorehabilitation · doi:10.12786/bn.2015.8.1.19 · Cited by 13
FTLD Treatment: Current Practice and Future Possibilities
Ljubenkov, P. A., & Boxer, A. L. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_18 · Cited by 16
Self-citationBehavioral Variant Frontotemporal Dementia
Boeve, B. F. (2022) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001105 · Cited by 17
Vernay, A., Sellal, F., & René, F. (2015) · Neurodegenerative Diseases · doi:10.1159/000439253 · Cited by 15
Huang, M., Zeng, B., Tseng, P., Hsu, C.-W., Wu, Y., Tu, Y., Stubbs, B., Carvalho, A. F., Liang, C., Chen, T., et al. (2023) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2023.06.013 · Cited by 16
Chronic Traumatic Encephalopathy: A Comparison with Alzheimer's Disease and Frontotemporal Dementia
Lesman‐Segev, O. H., Edwards, L., & Rabinovici, G. D. (2020) · Seminars in Neurology · doi:10.1055/s-0040-1715134 · Cited by 13
O’Connor, C. M. C., Clemson, L. M., da Silva, T. B. L., Piguet, O., Hodges, J. R., & Mioshi, E. (2013) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642013dn70200002 · Cited by 14
Iranian clinical practice guideline for amyotrophic lateral sclerosis
Boostani, R., Olfati, N., Shamshiri, H., Salimi, Z., Fatehi, F., Hedjazi, S. A., Fakharian, A., Ghasemi, M., Okhovat, A. A., Basiri, K., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1154579 · Cited by 12
KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids
Berlind, J. E., Lai, J. D., Lie, C., Vicente, J., Lam, K., Guo, S., Chang, J., Yu, V. L., & Ichida, J. K. (2025) · Neuron · doi:10.1016/j.neuron.2025.02.001 · Cited by 10
Clinical, Genetic and Neuropathological Features of Frontotemporal Dementia: An Update and Guide
Paulos, J. P., & Massano, J. (2013) · Acta Médica Portuguesa · doi:10.20344/amp.1226 · Cited by 9
Gossink, F. T. (2018) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) · Cited by 10
Wittebrood, C., Boban, M., Cagnin, A., Capellari, S., Winter, F. D., Djamshidian, A., Menéndez‐González, M., Hjermind, L. E., Krajčovičová, L., Krüger, J., et al. (2024) · European Journal of Neurology · doi:10.1111/ene.16446 · Cited by 8
Hope abandoned: memantine therapy in frontotemporal dementia
Hodges, J. R. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70001-2 · Cited by 10
Hernández, I., Mauleon, A., Rosende‐Roca, M., Alegret, M., Vinyes‐Junque, G., Espinosa, A., Sotolongo‐Grau, Ó., Becker, J. T., Valero, S., Tárraga, L., et al. (2014) · Current Alzheimer Research · doi:10.2174/1567205010666131212120443 · Cited by 9
Perry, D. C., & Rosen, H. J. (2016) · Wiley eBooks · doi:10.1002/9781118797662.ch5 · Cited by 9
Cranston, A., Kraev, I., Stewart, M. G., Horsley, D., Santos, R. X., Robinson, L., Dreesen, E., Armstrong, P., Palliyil, S., Harrington, C. R., et al. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111269 · Cited by 7
Deák, F., Kapoor, N., Prodan, C. I., & Hershey, L. A. (2016) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000000314 · Cited by 11
Neuropsychiatric Management of Young-Onset Dementias
Shinagawa, S. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.01.004 · Cited by 9
Accurate Etiological Diagnosis of Dementia Contributes to Better Clinical Care
Teng, E., & Mendez, M. F. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15174 · Cited by 7
Self-citationNevler, N., Cho, S., Cousins, K. A. Q., Ash, S., Olm, C. A., Shellikeri, S., Agmon, G., Gonzalez-Recober, C., Xie, S. X., Barker, M. S., et al. (2024) · Neurology · doi:10.1212/wnl.0000000000207926 · Cited by 7
Self-citationCahan, J. G., & Bonakdarpour, B. (2025) · Current Treatment Options in Neurology · doi:10.1007/s11940-025-00848-4 · Cited by 7
Memantine: updates from the past decade and implications for future novel therapeutic applications
Danysz, W., Hansen, N., Wiltfang, J., Kornhuber, J., Scheschonka, A., & Gravius, A. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-03017-8 · Cited by 7
A Case of Capgras Syndrome With Frontotemporal Dementia
Metin, B., Arıkan, M. K., Kalem, Ş. A., & Tarhan, N. (2019) · Cognitive and Behavioral Neurology · doi:10.1097/wnn.0000000000000191 · Cited by 7
Sanches, C., Amzallag, F., Dubois, B., Lévy, R., Truong, D. Q., Bikson, M., Teichmann, M., & Valero‐Cabré, A. (2022) · Brain Communications · doi:10.1093/braincomms/fcac050 · Cited by 8
Cognitive Continuum: Areas of Controversy with Cognitive Enhancers
Jones, K. C., Han, J. Y., & Shah, A. A. (2016) · Psychiatric Annals · doi:10.3928/00485713-20151221-02 · Cited by 6
Combined restorative and compensatory treatment for primary progressive aphasia: a case report
Cadório, I., Figueiredo, D., Martins, P., Cardoso, R., Santos, J., & Lousada, M. (2019) · Aphasiology · doi:10.1080/02687038.2019.1687842 · Cited by 6
Behavioral Variant Frontotemporal Dementia: Diagnosis and Treatment Interventions
Balachandran, S., Matlock, E. L., Conroy, M. L., & Lane, C. E. (2021) · Current Geriatrics Reports · doi:10.1007/s13670-021-00360-y · Cited by 7
Stockbridge, M. D., Tippett, D. C., Breining, B. L., & Hillis, A. E. (2022) · Aphasiology · doi:10.1080/02687038.2022.2084706 · Cited by 6
Shinagawa, S., & Miller, B. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410529-4.00069-3 · Cited by 6
Self-citationAppleby, B. S., & Tănase, D. (2014) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13100237 · Cited by 5
Wauters, E., Sleegers, K., Cruts, M., & Broeckhoven, C. V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805120-7.00009-9 · Cited by 6
Norata, D., Motolese, F., Magliozzi, A., Pilato, F., Lazzaro, V. D., Luzzi, S., & Capone, F. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1219737 · Cited by 4
Bajtošová, R., Holmerová, I., & Rusina, R. (2021) · Neurologie pro praxi · doi:10.36290/neu.2021.014 · Cited by 4
Pasquier, F., Lebouvier, T., & Lebert, F. (2016) · Neuropsychiatric symptoms of neurological disease · doi:10.1007/978-3-319-39138-0_13 · Cited by 4
Logopenic variant of primary progressive aphasia
Pressman, P., & Gorno‐Tempini, M. L. (2016) · Cambridge University Press eBooks · doi:10.1017/9781139924771.014 · Cited by 2
Frontotemporal dementia in psychiatric practice: diagnostic and therapeutic aspects
Колыхалов, И. В. (2018) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2018-2-109-115 · Cited by 3
An atypical presentation of frontotemporal dementia
Haskins, W., Ting, M. Y. L., Wood, J., Leong, C. E., Crump-Haill, O., Bovill, I., Janssen, J. C., Carswell, C. J., & Mizoguchi, R. (2019) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims.2019.09.09 · Cited by 3
Wider, C. W., Jasińska‐Myga, B., Konno, T., & Wszołek, Z. K. (2017) · Neurodegeneration · doi:10.1002/9781118661895.ch12 · Cited by 3
Chen, X., Chen, Y., Peng, G., & Liu, X. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s520351 · Cited by 2
Manouilidou, C., & Nerantzini, M. (2020) · Contemporary clinical neuroscience · doi:10.1007/978-3-030-35687-3_3 · Cited by 1
Patel, D., Andersen, S., Smith, K., & Ritter, A. R. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.828155 · Cited by 2
Frontotemporal dementia with cortico-basal syndrome
Zalyalova, Z. A., & MUNASIPOVA, S. E. (2022) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2022122021107 · Cited by 2
Fronto-Temporal Dementia, Diabetes Mellitus and Excessive Eating
Hamdy, R. C., Kinser, A. E., Dickerson, K., Kendall-Wilson, T., Dépelteau, A., & Whalen, K. (2018) · Gerontology and Geriatric Medicine · doi:10.1177/2333721418777057 · Cited by 2
The Development of Drug Therapies for Frontotemporal Dementia Caused by Progranulin Mutations
Muynck, L. D., & Damme, P. V. (2015) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681080680115030007 · Cited by 2
van Domburg, P., Vromen, M., Collet, J., Durlinger, M., Roufs, S., Schols, J. M. G. A., Sipers, W. M. W. H., Verkaaik, M., & Verhey, F. R. J. (2013) · Tijdschrift voor Neuropsychiatrie en Gedragsneurologie · doi:10.1007/s40533-013-0009-3 · Cited by 2
Frontotemporale Demenz: vorwiegend Verhaltens- und Sprachstörungen
Feneberg, E., Anderl‐Straub, S., & Otto, M. (2015) · DNP - Der Neurologe und Psychiater · doi:10.1007/s15202-015-0837-y · Cited by 2
Grover, S., Avasthi, A., & Gupta, G. (2016) · Journal of Geriatric Mental Health · doi:10.4103/2348-9995.181921 · Cited by 2
[Frontotemporal dementia : an update].
Soler, C. F., Giatrakou, V., Papa, S., Scheffler, M., & Frisoni, G. B. (2017) · PubMed · Cited by 2
Arrant, A. E., & Roberson, E. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801942-9.00006-9 · Cited by 3
Frontotemporal Lobar Degeneration –Agrammatic Primary Progressive Aphasia:Case Report
Galindo, C. J. A., Escudero, J. M. S., Rengifo, M. J. L., & Valencia, A. I. S. (2021) · Universitas Médica · doi:10.11144/javeriana.umed62-1.apha · Cited by 2
Ciccarelli, O. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70064-4 · Cited by 2
Aga, V. M., Shad, M. U., Zhu, H., & Salzman, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-800136-3.00023-5 · Cited by 2
Psychological structure of alexithymic space in patients with cardiovascular diseases
Brel, E. Y., Bokhan, N. A., & Stoyanova, I. Y. (2018) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2018-2-90-96 · Cited by 2
Trial results do not support off-label use of memantine for frontotemporal lobar degeneration
(2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.6 · Cited by 1
Tauopathies and its therapeutic interventions in Alzheimer’s disease
Sonawane, S. K., Rangappa, N., Chidambaram, H., & Chinnathambi, S. (2026) · Advances in pharmacology · doi:10.1016/bs.apha.2025.12.001 · Cited by 1
Pharmacologictherapy for FTD and related disorders
Tsai, R. M., & Boxer, A. L. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.021 · Cited by 1
Self-citationDementia and Social Neuroscience: Historical and Cultural Perspectives
Piguet, O. (2017) · Springer eBooks · doi:10.1007/978-3-319-68421-5_11 · Cited by 1
Impulsive, Disinhibited Behavior—Dining in a Restaurant
Hamdy, R. C., Kinser, A. E., Kendall-Wilson, T., Dépelteau, A., & Whalen, K. (2018) · Gerontology and Geriatric Medicine · doi:10.1177/2333721418756994 · Cited by 1
Behavioral Variant Frontotemporal Dementia
Ford, J. N., & Chiang, G. C.-Y. (2021) · Springer eBooks · doi:10.1007/978-3-030-82367-2_26 · Cited by 1
Sawyer, R. P., Shinagawa, S., & Miller, B. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813866-3.00003-5 · Cited by 1
Self-citationBensaïdane, M. R., Bouchard, R. W., Fortin, M., Houde, M., Rosa‐Neto, P., Poulin, S. P., Verret, L., Soucy, J., Beauregard, J., & Laforce, R. J. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.06.027 · Cited by 1
(2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.006 · Cited by 1
Semantic dementia (semantic variant primary progressive aphasia)
Hodges, J. R., Savage, S. A., & Patterson, K. E. (2016) · Cambridge University Press eBooks · doi:10.1017/9781139924771.013 · Cited by 1
Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816347-4.00007-6 · Cited by 1
Neurosurgical Management and Modifiable Risk Factors of Neurocognitive DeclinePreprint
Mohamed, A. A., Flynn, G., Haff, C. W., Mouhawasse, E., Faragalla, S., & Lucke-Wold, B. P. (2024) · Preprints.org · doi:10.20944/preprints202404.0678.v1 · Cited by 1
GABAergic modulation of beta power enhances motor adaptation in frontotemporal lobar degenerationPreprint
Hughes, L. E., Adams, N., Rouse, M. A., Naessens, M., Shaw, A. D., Murley, A. G., Cope, T., Holland, N., Nesbitt, D. J., Street, D., et al. (2024) · medRxiv · doi:10.1101/2024.06.28.24309636 · Cited by 1
Leitlinien zur „Pharmakotherapie neurodegenerativer Demenzen“
Fassbender, K., & Frölich, L. (2014) · Der Nervenarzt · doi:10.1007/s00115-014-4189-1
Psychopharmacologic Treatments for Alzheimer Disease and Related Dementias
Gomoll, B. P., Sanders, B., & Caserta, M. (2014) · Psychopharm Review · doi:10.1097/01.psyphr.0000442519.29442.6a · Cited by 1
Memantine kann die neuropsychiatrische Symptomatik nicht verbessern
Ludolph, A. C. (2013) · InFo Neurologie + Psychiatrie · doi:10.1007/s15005-013-0113-7
Dickerson, B. C. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.019
Dementia and Other Neurocognitive Disorders
Galvin, J. E., & Kelleher, M. E. (2015) · Advances in psychology, mental health, and behavioral studies (APMHBS) book series · doi:10.4018/978-1-4666-8478-2.ch005
Practicalmanagement of frontotemporal dementia
Huey, E. D., & Manoochehri, M. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781316091586.020
A fresh look at memory loss: Reexamining frontotemporal dementia
Zale, S., & Dickerson, L. (2017) · JAAPA : official journal of the American Academy of Physician Assistants · doi:10.1097/01.jaa.0000511785.99064.7e
Memantine (Generic and Namenda XR)
Budson, A. E., & Solomon, P. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-28661-9.00017-2
Challenges of a frontotemporal dementia patient
Bryant, R., & Miller, C. (2018) · Geriatric Nursing · doi:10.1016/j.gerinurse.2018.10.009
[Current approaches to the treatment of fronto-temporal dementia].
Fedorova, Y. (2019) · Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova · doi:10.17116/jnevro201911909218
Duco, L., Legendre, C., Châtellier, G., & Saint‐Jean, O. (2019) · Trends in Geriatric Healthcare · doi:10.36959/452/576
Anti-dementia Medications: Specific Agents
Zhang, F., Liu, X., Liu, Y., Wang, Y., & Le, W. (2020) · Springer eBooks · doi:10.1007/978-3-319-56015-1_283-1
Alzheimer’s disease and other neurocognitive disorders
Wang, L. Y., LaBardi, B. A., Raskind, M. A., & Peskind, E. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-800136-3.00014-4
Dementia and usage of N-methyl-d-aspartate receptor antagonists
Glynn-Servedio, B. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815854-8.00036-7
Memantine for Treatment of Dementia
Müller, T. H., & Kuhn, W. (2022) · Springer eBooks · doi:10.1007/978-3-319-56015-1_200-1
Metadata
- Authors
- Boxer, A. L., Knopman, D. S., Kaufer, D. I., Grossman, M., Onyike, C., Graf-Radford, N., Mendez, M., Kerwin, D., Lerner, A., Wu, C.-K., Koestler, M., Shapira, J., Sullivan, K., Klepac, K., Lipowski, K., Ullah, J., Fields, S., Kramer, J. H., Merrilees, J., Neuhaus, J., Mesulam, M. M., & Miller, B. L.
- Affiliations
- University of California, San Francisco (US)
- Mayo Clinic (US)
- University of North Carolina at Chapel Hill (US)
- University of Pennsylvania (US)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- Northwestern University (US)
- Case Western Reserve University (US)
- Texas Tech University (US)
- Corresponding author
- Boxer, Adam L
- ORCID
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 12
- Issue
- 2
- Pages
- 149-156
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC3756890
- OpenAlex
- W2106046611
- Cited by
- 228
- References
- 31
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 21 · 2018: 15 · 2017: 22 · 2016: 21 · 2015: 23 · 2014: 24 · 2013: 18
- FWCI
- 20.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Larry L. Hillblom Foundation (P50 AG1657303)
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Agouron Institute
- TauRx Pharmaceuticals
- National Institutes of Health (UL1TR000150)
- Genentech
- University of California, San Francisco (P50 AG023501, P01AG019724)
- National Institute on Aging (P50AG1657303, R01AG031278, P30AG013854, R01AG038791, P01AG019724, P50AG023501)
- National Institute on Deafness and Other Communication Disorders (R01DC008552)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- memantine, frontotemporal lobar degeneration, behavioral variant frontotemporal dementia, semantic dementia, neuropsychiatric symptoms, NPI, Clinical Global Impression of Change, treatment efficacy, drug tolerability
- MeSH terms
- Aged, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Memantine, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Retrospective Studies, Chi-Square Distribution, Treatment Outcome, Excitatory Amino Acid Antagonists, Frontotemporal Lobar Degeneration
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
